prikaz prve stranice dokumenta CSF tau proteins in evaluation of patients with suspected dementia
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CSF tau proteins in evaluation of patients with suspected dementia
U: New Trends in Alzheimer and Parkinson related disorders: ADPD 2007.. Bologna Medimond, 2008. str. 239-243. urn:nbn:hr:105:399216
Šimić, Goran; Boban, Marko; Šarac, Helena; Grbić, Kristina; Hof, Patrick R.; Hamann, C.; Ackl, Nibal; Bader, Benedikt; Danek, Adrian

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Šimić, G., Boban, M., Šarac, H., Grbić, K., Hof, P. R., Hamann, C. ... Danek, A. (2008). CSF tau proteins in evaluation of patients with suspected dementia. New Trends in Alzheimer and Parkinson related disorders: ADPD 2007. (str. 239-243). Bologna Medimond. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:105:399216

Šimić, Goran, et al. "CSF tau proteins in evaluation of patients with suspected dementia." New Trends in Alzheimer and Parkinson related disorders: ADPD 2007., Bologna Medimond, 2008, str. 239-243. https://urn.nsk.hr/urn:nbn:hr:105:399216

Šimić, Goran, Marko Boban, Helena Šarac, Kristina Grbić, Patrick R. Hof, C. Hamann, Nibal Ackl, Benedikt Bader i Adrian Danek. "CSF tau proteins in evaluation of patients with suspected dementia." U New Trends in Alzheimer and Parkinson related disorders: ADPD 2007., 239-243. Bologna Medimond, 2008. Citirano 17.04.2024.. https://urn.nsk.hr/urn:nbn:hr:105:399216

Šimić, G., et al. (2008) 'CSF tau proteins in evaluation of patients with suspected dementia', New Trends in Alzheimer and Parkinson related disorders: ADPD 2007., Bologna Medimond, str. 239-243. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:105:399216 (Datum pristupa: 17.04.2024.)

Šimić G, Boban M, Šarac H, Grbić K, Hof PR, Hamann C, i sur.. CSF tau proteins in evaluation of patients with suspected dementia. New Trends in Alzheimer and Parkinson related disorders: ADPD 2007.. Bologna Medimond; 2008. Str. 239-243. [pristupljeno 17.04.2024.] Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:399216

G. Šimić, et al., "CSF tau proteins in evaluation of patients with suspected dementia", New Trends in Alzheimer and Parkinson related disorders: ADPD 2007. Bologna Medimond, 2008. [Online] Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:399216 [Citirano: 17.04.2024.]

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Podaci o radu
Naslov (engleski)CSF tau proteins in evaluation of patients with suspected dementia
AutorGoran Šimić
AutorMarko Boban
AutorHelena Šarac
AutorKristina Grbić
AutorPatrick R. Hof
AutorC. Hamann
AutorNibal Ackl
AutorBenedikt Bader
AutorAdrian Danek
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Sažetak (engleski)
Using commercially available ELISA kits, we evaluated the diagnostic value of CSF total tau protein (t-tau), tau phosphorylated at threonine 181 and serine 199 (p-tau181 and p-tau199) in early Alzheimer's disease (AD) versus healthy controls (HC) and other primary causes of dementia, such as frontotemporal dementia (FTD), vascular dementia (VaD) and dementia with Lewy-bodies (DLB). Mean CSF t-tau and CSF p-tau181 levels were significantly elevated in AD patients compared to FTD, VaD and HC. Discrimination between AD and DLB was maximized by using p-tau181 with a sensitivity of 91% and a specificity of 94%, whereas t-tau was optimal to separate AD from VaD with a sensitivity of 91% and specificity of 95%. P-tau199 showed low specificity of 20-30% in distinguishing AD from other groups when sensitivity was set at 85% or greater. We concluded that p-tau181 and t-tau represent useful biological markers for differentiating early AD from other causes of dementia.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov zbornikaNew Trends in Alzheimer and Parkinson related disorders: ADPD 2007.
Brojčani podacistr. 239-243
ISBN9788875874056
URN:NBNurn:nbn:hr:105:399216
Datum objave publikacije2008
SkupNaziv: The 8th International Conference on Alzheimer’s and Parkinson’s Diseases
Kratica: AD/PD
Lokacija: Salzburg, Austrija
Datum početka: 2007-03-14
Datum završetka: 2007-03-18
Vrsta izlaganja: Predavanje
Vrsta resursaTekst
IzdavačBologna Medimond
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-04-11 10:51:08