prikaz prve stranice dokumenta Association of Lipid Peroxidation Product 4-Hydroxynonenal with Post-Traumatic Stress Disorder
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Association of Lipid Peroxidation Product 4-Hydroxynonenal with Post-Traumatic Stress Disorder
Biomolecules, 11 (2021), 9; 1365. https://doi.org/10.3390/biom11091365
Nikolac Perković, Matea; Milković, Lidija; Uzun, Suzana; Mimica, Ninoslav; Pivac, Nela; Waeg, Georg; Žarković, Neven

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Nikolac Perković, M., Milković, L., Uzun, S., Mimica, N., Pivac, N., Waeg, G. i Žarković, N. (2021). Association of Lipid Peroxidation Product 4-Hydroxynonenal with Post-Traumatic Stress Disorder. Biomolecules, 11. (9). doi: 10.3390/biom11091365

Nikolac Perković, Matea, et al. "Association of Lipid Peroxidation Product 4-Hydroxynonenal with Post-Traumatic Stress Disorder." Biomolecules, vol. 11, br. 9, 2021. https://doi.org/10.3390/biom11091365

Nikolac Perković, Matea, Lidija Milković, Suzana Uzun, Ninoslav Mimica, Nela Pivac, Georg Waeg i Neven Žarković. "Association of Lipid Peroxidation Product 4-Hydroxynonenal with Post-Traumatic Stress Disorder." Biomolecules 11, br. 9 (2021). https://doi.org/10.3390/biom11091365

Nikolac Perković, M., et al. (2021) 'Association of Lipid Peroxidation Product 4-Hydroxynonenal with Post-Traumatic Stress Disorder', Biomolecules, 11(9). doi: 10.3390/biom11091365

Nikolac Perković M, Milković L, Uzun S, Mimica N, Pivac N, Waeg G, i sur.. Association of Lipid Peroxidation Product 4-Hydroxynonenal with Post-Traumatic Stress Disorder. Biomolecules [Internet]. 15.09.2021. [pristupljeno 12.11.2024.];11(9). doi: 10.3390/biom11091365

M. Nikolac Perković, et al., "Association of Lipid Peroxidation Product 4-Hydroxynonenal with Post-Traumatic Stress Disorder", Biomolecules, vol. 11, br. 9, Rujan 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:112543. [Citirano: 12.11.2024.]

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Podaci o radu
Naslov (engleski)Association of Lipid Peroxidation Product 4-Hydroxynonenal with Post-Traumatic Stress Disorder
AutorMatea Nikolac Perković
AutorLidija Milković
AutorSuzana Uzun
AutorNinoslav Mimica
AutorNela Pivac
AutorGeorg Waeg
AutorNeven Žarković
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PSIHIJATRIJU I PSIHOLOŠKU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Sažetak (engleski)
Repeated activation of the hypothalamic-pituitary-adrenal axis system, sleep disturbances, and other symptoms related to posttraumatic stress disorder (PTSD) elevate reactive oxygen species, increase inflammation, and accelerate cellular aging, leading to neuroprogression and cognitive decline. However, there is no information about possible involvement of 4-hydroxynonenal (4-HNE), the product of lipid peroxidation associated with stress-associated diseases, in the complex etiology of PTSD. Therefore, the aim of this study was to compare the plasma levels of 4-HNE between war veterans with PTSD (n = 62) and age-, sex- and ethnicity- matched healthy control subjects (n = 58) in order to evaluate the potential of HNE-modified proteins as blood-based biomarker of PTSD. The genuine 4-HNE-Enzyme-Linked Immunosorbent Assay (HNE-ELISA), based on monoclonal antibody specific for HNE-histidine (HNE-His) adducts, was used to determine plasma HNE-protein conjugates. Our results revealed significantly elevated levels of 4-HNE in patients with PTSD. Moreover, the accumulation of plasma 4-HNE seems to increase with aging but in a negative correlation with BMI, showing specific pattern of change for individuals diagnosed with PTSD. These findings suggest that oxidative stress and altered lipid metabolism reflected by increase of 4-HNE might be associated with PTSD. If confirmed with further studies, elevated 4-HNE plasma levels might serve as a potential biomarker of PTSD.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomolecules
Brojčani podacivol. 11, br. 9, 1365
e-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom11091365
URN:NBNurn:nbn:hr:105:112543
Datum objave publikacije2021-09-15
URL dokumentahttps://www.mdpi.com/2218-273X/11/9/1365
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-04-26 09:05:48