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Human DLG1 and SCRIB Are Distinctly Regulated Independently of HPV-16 during the Progression of Oropharyngeal Squamous Cell Carcinomas: A Preliminary Analysis
Cancers, 13 (2021), 17; 4461. https://doi.org/10.3390/cancers13174461
Lulić, Lucija; Jakovčević, Antonia; Manojlović, Luka; Dediol, Emil; Banks, Lawrence; Tomaić, Vjekoslav

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Lulić, L., Jakovčević, A., Manojlović, L., Dediol, E., Banks, L. i Tomaić, V. (2021). Human DLG1 and SCRIB Are Distinctly Regulated Independently of HPV-16 during the Progression of Oropharyngeal Squamous Cell Carcinomas: A Preliminary Analysis. Cancers, 13. (17). doi: 10.3390/cancers13174461

Lulić, Lucija, et al. "Human DLG1 and SCRIB Are Distinctly Regulated Independently of HPV-16 during the Progression of Oropharyngeal Squamous Cell Carcinomas: A Preliminary Analysis." Cancers, vol. 13, br. 17, 2021. https://doi.org/10.3390/cancers13174461

Lulić, Lucija, Antonia Jakovčević, Luka Manojlović, Emil Dediol, Lawrence Banks i Vjekoslav Tomaić. "Human DLG1 and SCRIB Are Distinctly Regulated Independently of HPV-16 during the Progression of Oropharyngeal Squamous Cell Carcinomas: A Preliminary Analysis." Cancers 13, br. 17 (2021). https://doi.org/10.3390/cancers13174461

Lulić, L., et al. (2021) 'Human DLG1 and SCRIB Are Distinctly Regulated Independently of HPV-16 during the Progression of Oropharyngeal Squamous Cell Carcinomas: A Preliminary Analysis', Cancers, 13(17). doi: 10.3390/cancers13174461

Lulić L, Jakovčević A, Manojlović L, Dediol E, Banks L, Tomaić V. Human DLG1 and SCRIB Are Distinctly Regulated Independently of HPV-16 during the Progression of Oropharyngeal Squamous Cell Carcinomas: A Preliminary Analysis. Cancers [Internet]. 04.09.2021. [pristupljeno 06.12.2024.];13(17). doi: 10.3390/cancers13174461

L. Lulić, A. Jakovčević, L. Manojlović, E. Dediol, L. Banks i V. Tomaić, "Human DLG1 and SCRIB Are Distinctly Regulated Independently of HPV-16 during the Progression of Oropharyngeal Squamous Cell Carcinomas: A Preliminary Analysis", Cancers, vol. 13, br. 17, Rujan 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:181641. [Citirano: 06.12.2024.]

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Naslov (engleski)Human DLG1 and SCRIB Are Distinctly Regulated Independently of HPV-16 during the Progression of Oropharyngeal Squamous Cell Carcinomas: A Preliminary Analysis
AutorLucija Lulić
AutorAntonia Jakovčević
AutorLuka Manojlović
AutorEmil Dediol
AutorLawrence Banks
AutorVjekoslav Tomaić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MAKSILOFACIJALNU KIRURGIJU SA STOMATOLOGIJOM)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Sažetak (engleski)
The major causative agents of head and neck squamous cell carcinomas (HNSCCs) are either environmental factors, such as tobacco and alcohol consumption, or infection with oncogenic human papillomaviruses (HPVs). An important aspect of HPV-induced oncogenesis is the targeting by the E6 oncoprotein of PDZ domain-containing substrates for proteasomal destruction. Tumor suppressors DLG1 and SCRIB are two of the principal PDZ domain-containing E6 targets. Both have been shown to play critical roles in the regulation of cell growth and polarity and in maintaining the structural integrity of the epithelia. We investigated how modifications in the cellular localization and protein expression of DLG1 and SCRIB in HPV16-positive and HPV-negative histologic oropharyngeal squamous cell carcinomas (OPSCC) might reflect disease progression. HPV presence was determined by p16 staining and HPV genotyping. Whilst DLG1 expression levels did not differ markedly between HPV-negative and HPV16-positive OPSCCs, it appeared to be relocated from cell–cell contacts to the cytoplasm in most samples, regardless of HPV16 positivity. This indicates that alterations in DLG1 distribution could contribute to malignant progression in OPSCCs. Interestingly, SCRIB was also relocated from cell–cell contacts to the cytoplasm in the tumor samples in comparison with normal tissue, regardless of HPV16 status, but in addition there was an obvious reduction in SCRIB expression in higher grade tumors. Strikingly, loss of SCRIB was even more pronounced in HPV16-positive OPSCCs. These alterations in SCRIB levels may contribute to transformation and loss of tissue architecture in the process of carcinogenesis and could potentially serve as markers in the development of OPSCCs.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCancers
Brojčani podacivol. 13, br. 17, 4461
e-ISSN2072-6694
DOIhttps://doi.org/10.3390/cancers13174461
URN:NBNurn:nbn:hr:105:181641
Datum objave publikacije2021-09-04
URL dokumentahttps://www.mdpi.com/2072-6694/13/17/4461
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-05-09 08:23:44