prikaz prve stranice dokumenta Lentivirus- or AAV-mediated gene therapy interventions in ischemic stroke: A systematic review of preclinical in vivo studies
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Lentivirus- or AAV-mediated gene therapy interventions in ischemic stroke: A systematic review of preclinical in vivo studies
Journal of Cerebral Blood Flow & Metabolism, 42 (2022), 2; 219-236. https://doi.org/10.1177/0271678X211039997
Skukan, Laura; Brezak, Matea; Ister, Rok; Klimaschewski, Lars; Vojta, Aleksandar; Zoldoš, Vlatka; Gajović, Srećko

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Skukan, L., Brezak, M., Ister, R., Klimaschewski, L., Vojta, A., Zoldoš, V. i Gajović, S. (2022). Lentivirus- or AAV-mediated gene therapy interventions in ischemic stroke: A systematic review of preclinical in vivo studies. Journal of Cerebral Blood Flow & Metabolism, 42. (2), 219-236. doi: 10.1177/0271678X211039997

Skukan, Laura, et al. "Lentivirus- or AAV-mediated gene therapy interventions in ischemic stroke: A systematic review of preclinical in vivo studies." Journal of Cerebral Blood Flow & Metabolism, vol. 42, br. 2, 2022, str. 219-236. https://doi.org/10.1177/0271678X211039997

Skukan, Laura, Matea Brezak, Rok Ister, Lars Klimaschewski, Aleksandar Vojta, Vlatka Zoldoš i Srećko Gajović. "Lentivirus- or AAV-mediated gene therapy interventions in ischemic stroke: A systematic review of preclinical in vivo studies." Journal of Cerebral Blood Flow & Metabolism 42, br. 2 (2022): 219-236. https://doi.org/10.1177/0271678X211039997

Skukan, L., et al. (2022) 'Lentivirus- or AAV-mediated gene therapy interventions in ischemic stroke: A systematic review of preclinical in vivo studies', Journal of Cerebral Blood Flow & Metabolism, 42(2), str. 219-236. doi: 10.1177/0271678X211039997

Skukan L, Brezak M, Ister R, Klimaschewski L, Vojta A, Zoldoš V, i sur.. Lentivirus- or AAV-mediated gene therapy interventions in ischemic stroke: A systematic review of preclinical in vivo studies. Journal of Cerebral Blood Flow & Metabolism [Internet]. 02.2022. [pristupljeno 13.04.2024.];42(2):219-236. doi: 10.1177/0271678X211039997

L. Skukan, et al., "Lentivirus- or AAV-mediated gene therapy interventions in ischemic stroke: A systematic review of preclinical in vivo studies", Journal of Cerebral Blood Flow & Metabolism, vol. 42, br. 2, str. 219-236, Veljača 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:642820. [Citirano: 13.04.2024.]

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Podaci o radu
Naslov (engleski)Lentivirus- or AAV-mediated gene therapy interventions in ischemic stroke: A systematic review of preclinical in vivo studies
AutorLaura Skukan
AutorMatea Brezak
AutorRok Ister
AutorLars Klimaschewski
AutorAleksandar Vojta
AutorVlatka Zoldoš
AutorSrećko Gajović
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA HISTOLOGIJU I EMBRIOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Citologija, histologija i embriologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Sažetak (engleski)
Due to the limited therapeutic options after ischemic stroke, gene therapy has emerged as a promising choice, especially with recent advances in viral vector delivery systems. Therefore, we aimed to provide the current state of the art of lentivirus (LV) and adeno-associated virus (AAV) mediated gene interventions in preclinical ischemic stroke models. A systematic analysis including qualitative and quantitative syntheses of studies published until December 2020 was performed. Most of the 87 selected publications used adult male rodents and the preferred stroke model was transient middle cerebral artery occlusion. LV and AAV vectors were equally used for transgene delivery, however loads of AAVs were higher than LVs. Serotypes having broad cell tropism, the use of constitutive promoters, and virus delivery before the stroke induction via stereotaxic injection in the cortex and striatum were preferred in the analyzed studies. The meta-analysis based on infarct volume as the primary outcome confirmed the efficacy of the preclinical interventions. The quality assessment exposed publication bias and setbacks in regard to risks of bias and study relevance. The translational potential could increase by using specific cell targeting, post-stroke interventions, non-invasive systematic delivery, and use of large animals.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Cerebral Blood Flow & Metabolism
Brojčani podacivol. 42, br. 2, str. 219-236
p-ISSN0271-678X
e-ISSN1559-7016
DOIhttps://doi.org/10.1177/0271678X211039997
URN:NBNurn:nbn:hr:105:642820
Datum objave publikacije2022-02
URL dokumentahttp://journals.sagepub.com/doi/10.1177/0271678X211039997
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2022-05-13 07:46:26