Quercetin as a Novel Therapeutic Approach for Lymphoma

Znanstveni rad - Pregledni rad

• Autor: Saiedeh Razi Soofiyani
• Autor: Kamran Hosseini
• Autor: Haleh Forouhandeh
• Autor: Tohid Ghasemnejad
• Autor: Vahideh Tarhriz
• Autor: Parina Asgharian
• Autor: Željko Reiner
• Autor: Javad Sharifi-Rad
• Autor: William C. Cho
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA INTERNU MEDICINU)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Interna medicina

Sažetak (engleski)

Lymphoma is a name for malignant diseases of the lymphatic system including Hodgkin’s lymphoma and non-Hodgkin’s lymphoma. Although several approaches are used for the treatment of these diseases, some of them are not successful and have serious adverse effects. Therefore, other effective treatment methods might be interesting. Studies have indicated that plant ingredients play a key role in treating several diseases. Some plants have already shown a potential therapeutic effect on many malignant diseases. Quercetin is a flavonoid found in different plants and could be useful in the treatment of different malignant diseases. Quercetin has its antimalignant effects through targeting main survival pathways activated in tumor cells. In vitro/in vivo experimental studies have demonstrated that quercetin possesses a cytotoxic effect on lymphoid cancer cells. Regardless of the optimum results that have been obtained from both in vitro/in vivo studies, few clinical studies have analyzed the antitumor effects of quercetin in lymphoid cancers. Thus, it seems that more clinical studies should introduce quercetin as a therapeutic, alone or in combination with other chemotherapy agents. Here, in this study, we reviewed the anticancer effects of quercetin and highlighted the potential therapeutic effects of quercetin in various types of lymphoma.

• Ključne riječi (engleski): Animals; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Apoptosis / drug effects; Humans; Lymphoma / drug therapy; Lymphoma / metabolism; Quercetin / pharmacology; Quercetin / therapeutic use; Signal Transduction / drug effects
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Pregledni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Oxidative Medicine and Cellular Longevity
• Brojčani podaci: vol. 2021, 3157867
• p-ISSN: 1942-0900
• e-ISSN: 1942-0994
• DOI: https://doi.org/10.1155/2021/3157867
• URN:NBN: urn:nbn:hr:105:904221
• Datum objave publikacije: 2021
• URL dokumenta: https://www.hindawi.com/journals/omcl/2021/3157867/
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2022-05-19 09:20:13