prikaz prve stranice dokumenta Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study
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Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study
Frontiers in Immunology, 12 (2021); 633214. https://doi.org/10.3389/fimmu.2021.633214
Prenc, Ema; Pulanić, Dražen; Pucic-Bakovic, Maja; Ugrina, Ivo; Desnica, Lana; Milošević, Milan; Pirsl, Filip; Mitchell, Sandra; Rose, Jeremy; Vrhovac, Radovan; Nemet, Damir; Lauc, Gordan; Pavletić, Steven Ž.

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Prenc, E., Pulanić, D., Pucic Bakovic, M., Ugrina, I., Desnica, L., Milošević, M. ... Pavletić, S. Ž. (2021). Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study. Frontiers in Immunology, 12.. doi: 10.3389/fimmu.2021.633214

Prenc, Ema, et al. "Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study." Frontiers in Immunology, vol. 12, 2021. https://doi.org/10.3389/fimmu.2021.633214

Prenc, Ema, Dražen Pulanić, Maja Pucic Bakovic, Ivo Ugrina, Lana Desnica, Milan Milošević, Filip Pirsl, et al. "Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study." Frontiers in Immunology 12 (2021). https://doi.org/10.3389/fimmu.2021.633214

Prenc, E., et al. (2021) 'Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study', Frontiers in Immunology, 12. doi: 10.3389/fimmu.2021.633214

Prenc E, Pulanić D, Pucic Bakovic M, Ugrina I, Desnica L, Milošević M, i sur.. Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study. Frontiers in Immunology [Internet]. 14.07.2021. [pristupljeno 05.05.2024.];12. doi: 10.3389/fimmu.2021.633214

E. Prenc, et al., "Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study", Frontiers in Immunology, vol. 12, Srpanj 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:644862. [Citirano: 05.05.2024.]

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Naslov (engleski)Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study
AutorEma Prenc
AutorDražen Pulanić
AutorMaja Pucic-Bakovic
AutorIvo Ugrina
AutorLana Desnica
AutorMilan Milošević
AutorFilip Pirsl
AutorSandra Mitchell
AutorJeremy Rose
AutorRadovan Vrhovac
AutorDamir Nemet
AutorGordan Lauc
AutorSteven Ž. Pavletić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ZDRAVSTVENU EKOLOGIJU, MEDICINU RADA I SPORTA)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Javno zdravstvo i zdravstvena zaštita
Zdravstvena ekologija
Sažetak (engleski)
Chronic graft-versus-host disease (cGvHD) is a systemic alloimmune and autoimmune disorder and a major late complication of allogeneic hematopoietic stem cell transplantation (alloHSCT). The disease is characterized by an altered homeostasis of the humoral immune response. Immunoglobulin G (IgG) glycoprotein is the main effector molecule of the humoral immune response. Changes in IgG glycosylation are associated with a number of autoimmune diseases. IgG glycosylation analysis was done by the means of liquid chromatography in the National Institutes of Health (NIH) cohort of 213 cGvHD patients. The results showed statistically significant differences with regards to cGvHD NIH joint/fascia and skin score, disease activity and intensity of systemic immunosuppression. ROC analysis confirmed that IgG glycosylation increases specificity and sensitivity of models using laboratory parameters and markers of inflammation associated with cGvHD (eosinophil count, complement components C3 and C4 and inflammation markers: albumin, CRP and thrombocyte count). This research shows that IgG glycosylation may play a significant role in cGvHD pathology. Further research could contribute to the understanding of the disease biology and lead to the clinical biomarker development to allow personalized approaches to chronic GvHD therapy.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFrontiers in Immunology
Brojčani podacivol. 12, 633214
e-ISSN1664-3224
DOIhttps://doi.org/10.3389/fimmu.2021.633214
URN:NBNurn:nbn:hr:105:644862
Datum objave publikacije2021-07-14
URL dokumentahttps://www.frontiersin.org/articles/10.3389/fimmu.2021.633214/full
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-05-25 11:21:20