prikaz prve stranice dokumenta Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging
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Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging
Scientific Reports, 11 (2021), 1; 14020. https://doi.org/10.1038/s41598-021-93054-6
Planinc, Ivo; Garcia-Canadilla, Patricia; Dejea, Hector; Ilic, Ivana; Guasch, Eduard; Zamora, Monica; Crispi, Fàtima; Stampanoni, Marco; Milicic, Davor; Bijnens, Bart; Bonnin, Anne; Čikes, Maja

Citirajte ovaj rad

Planinc, I., Garcia Canadilla, P., Dejea, H., Ilic, I., Guasch, E., Zamora, M. ... Čikes, M. (2021). Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging. Scientific Reports, 11. (1). doi: 10.1038/s41598-021-93054-6

Planinc, Ivo, et al. "Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging." Scientific Reports, vol. 11, br. 1, 2021. https://doi.org/10.1038/s41598-021-93054-6

Planinc, Ivo, Patricia Garcia Canadilla, Hector Dejea, Ivana Ilic, Eduard Guasch, Monica Zamora, Fàtima Crispi, et al. "Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging." Scientific Reports 11, br. 1 (2021). https://doi.org/10.1038/s41598-021-93054-6

Planinc, I., et al. (2021) 'Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging', Scientific Reports, 11(1). doi: 10.1038/s41598-021-93054-6

Planinc I, Garcia Canadilla P, Dejea H, Ilic I, Guasch E, Zamora M, i sur.. Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging. Scientific Reports [Internet]. 07.07.2021. [pristupljeno 06.05.2024.];11(1). doi: 10.1038/s41598-021-93054-6

I. Planinc, et al., "Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging", Scientific Reports, vol. 11, br. 1, Srpanj 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:371839. [Citirano: 06.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:371839
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Podaci o radu
Naslov (engleski)Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging
AutorIvo Planinc
AutorPatricia Garcia-Canadilla
AutorHector Dejea
AutorIvana Ilic
AutorEduard Guasch
AutorMonica Zamora
AutorFàtima Crispi
AutorMarco Stampanoni
AutorDavor Milicic
AutorBart Bijnens
AutorAnne Bonnin
AutorMaja Čikes
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Abstract Cardiovascular research is in an ongoing quest for a superior imaging method to integrate gross-anatomical information with microanatomy, combined with quantifiable parameters of cardiac structure. In recent years, synchrotron radiation-based X-ray Phase Contrast Imaging (X-PCI) has been extensively used to characterize soft tissue in detail. The objective was to use X-PCI to comprehensively quantify ischemic remodeling of different myocardial structures, from cell to organ level, in a rat model of myocardial infarction. Myocardial infarction-induced remodeling was recreated in a well-established rodent model. Ex vivo rodent hearts were imaged by propagation based X-PCI using two configurations resulting in 5.8 µm and 0.65 µm effective pixel size images. The acquired datasets were used for a comprehensive assessment of macrostructural changes including the whole heart and vascular tree morphology, and quantification of left ventricular myocardial thickness, mass, volume, and organization. On the meso-scale, tissue characteristics were explored and compared with histopathological methods, while microstructural changes were quantified by segmentation of cardiomyocytes and calculation of cross-sectional areas. Propagation based X-PCI provides detailed visualization and quantification of morphological changes on whole organ, tissue, vascular as well as individual cellular level of the ex vivo heart, with a single, non-destructive 3D imaging modality.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaScientific Reports
Brojčani podacivol. 11, br. 1, 14020
e-ISSN2045-2322
DOIhttps://doi.org/10.1038/s41598-021-93054-6
URN:NBNurn:nbn:hr:105:371839
Datum objave publikacije2021-07-07
URL dokumentahttp://www.nature.com/articles/s41598-021-93054-6
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-06-09 09:26:38