prikaz prve stranice dokumenta Macrophage Infiltration Correlates with Genomic Instability in Classic Hodgkin Lymphoma
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Macrophage Infiltration Correlates with Genomic Instability in Classic Hodgkin Lymphoma
Biomedicines, 10 (2022), 3; 579. https://doi.org/10.3390/biomedicines10030579
Hančić, Suzana; Gršković, Paula; Gašparov, Slavko; Ostojić Kolonić, Slobodanka; Dominis, Mara; Korać, Petra

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Hančić, S., Gršković, P., Gašparov, S., Ostojić Kolonić, S., Dominis, M. i Korać, P. (2022). Macrophage Infiltration Correlates with Genomic Instability in Classic Hodgkin Lymphoma. Biomedicines, 10. (3). doi: 10.3390/biomedicines10030579

Hančić, Suzana, et al. "Macrophage Infiltration Correlates with Genomic Instability in Classic Hodgkin Lymphoma." Biomedicines, vol. 10, br. 3, 2022. https://doi.org/10.3390/biomedicines10030579

Hančić, Suzana, Paula Gršković, Slavko Gašparov, Slobodanka Ostojić Kolonić, Mara Dominis i Petra Korać. "Macrophage Infiltration Correlates with Genomic Instability in Classic Hodgkin Lymphoma." Biomedicines 10, br. 3 (2022). https://doi.org/10.3390/biomedicines10030579

Hančić, S., et al. (2022) 'Macrophage Infiltration Correlates with Genomic Instability in Classic Hodgkin Lymphoma', Biomedicines, 10(3). doi: 10.3390/biomedicines10030579

Hančić S, Gršković P, Gašparov S, Ostojić Kolonić S, Dominis M, Korać P. Macrophage Infiltration Correlates with Genomic Instability in Classic Hodgkin Lymphoma. Biomedicines [Internet]. 01.03.2022. [pristupljeno 11.11.2024.];10(3). doi: 10.3390/biomedicines10030579

S. Hančić, P. Gršković, S. Gašparov, S. Ostojić Kolonić, M. Dominis i P. Korać, "Macrophage Infiltration Correlates with Genomic Instability in Classic Hodgkin Lymphoma", Biomedicines, vol. 10, br. 3, Ožujak 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:651032. [Citirano: 11.11.2024.]

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Naslov (engleski)Macrophage Infiltration Correlates with Genomic Instability in Classic Hodgkin Lymphoma
AutorSuzana Hančić
AutorPaula Gršković
AutorSlavko Gašparov
AutorSlobodanka Ostojić Kolonić
AutorMara Dominis
AutorPetra Korać
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PATOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Hodgkin lymphoma (HL) is a biologically diverse group of lymphoid tumors, which accounts for 1% of all de novo neoplasms in the world’s population. It is divided into two main groups: the more common classic Hodgkin lymphoma (cHL) and the less common nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). cHL is further divided into four subtypes, which differ in morphology and the contents of tumor microenvironment. Macrophages are one of the components of tumor microenvironment known to contribute to creating an immunosuppressive microenvironment, which inhibits the activity of cells expressing granzyme B against tumor cells, even when tumor cells are infected with Epstein–Barr virus (EBV). Our research aimed to explore the association between the specific contents of tumor microenvironment and the genetic anomalies in tumor cells. The presence and the relative percentage of cytotoxic T lymphocytes and macrophages was detected by immunohistochemical staining of the antigens specific for certain cell populations. Fluorescent in situ hybridization was used to detect anomalies in the genome of tumor cells and in situ hybridization was used to detect the presence of EBV. Our results show an association between the number of CD163+ macrophages and the number of TP53 copies or BCL6 gene translocation. Patients who had a higher number of CD163+ macrophages infiltrating tumor tissue and three or higher number of copies of TP53 showed poorer survival. We conclude that the presence of macrophages may contribute to genetic instability in cHL, which drives the progression of cHL and decreases survival of the patients.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedicines
Brojčani podacivol. 10, br. 3, 579
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines10030579
URN:NBNurn:nbn:hr:105:651032
Datum objave publikacije2022-03-01
URL dokumentahttps://www.mdpi.com/2227-9059/10/3/579
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-09-28 08:16:36