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Antinociceptive Actions of Botulinum Toxin A1 on Immunogenic Hypersensitivity in Temporomandibular Joint of Rats
Toxins, 14 (2022), 3; 161. https://doi.org/10.3390/toxins14030161
Muñoz-Lora, Victor Ricardo Manuel; Dugonjić Okroša, Ana; Matak, Ivica; Del Bel Cury, Altair Antoninha; Kalinichev, Mikhail; Lacković, Zdravko

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Muñoz Lora, V. R. M., Dugonjić Okroša, A., Matak, I., Del Bel Cury, A. A., Kalinichev, M. i Lacković, Z. (2022). Antinociceptive Actions of Botulinum Toxin A1 on Immunogenic Hypersensitivity in Temporomandibular Joint of Rats. Toxins, 14. (3). doi: 10.3390/toxins14030161

Muñoz Lora, Victor Ricardo Manuel, et al. "Antinociceptive Actions of Botulinum Toxin A1 on Immunogenic Hypersensitivity in Temporomandibular Joint of Rats." Toxins, vol. 14, br. 3, 2022. https://doi.org/10.3390/toxins14030161

Muñoz Lora, Victor Ricardo Manuel, Ana Dugonjić Okroša, Ivica Matak, Altair Antoninha Del Bel Cury, Mikhail Kalinichev i Zdravko Lacković. "Antinociceptive Actions of Botulinum Toxin A1 on Immunogenic Hypersensitivity in Temporomandibular Joint of Rats." Toxins 14, br. 3 (2022). https://doi.org/10.3390/toxins14030161

Muñoz Lora, V. R. M., et al. (2022) 'Antinociceptive Actions of Botulinum Toxin A1 on Immunogenic Hypersensitivity in Temporomandibular Joint of Rats', Toxins, 14(3). doi: 10.3390/toxins14030161

Muñoz Lora VRM, Dugonjić Okroša A, Matak I, Del Bel Cury AA, Kalinichev M, Lacković Z. Antinociceptive Actions of Botulinum Toxin A1 on Immunogenic Hypersensitivity in Temporomandibular Joint of Rats. Toxins [Internet]. 23.02.2022. [pristupljeno 29.11.2024.];14(3). doi: 10.3390/toxins14030161

V. R. M. Muñoz Lora, A. Dugonjić Okroša, I. Matak, A. A. Del Bel Cury, M. Kalinichev i Z. Lacković, "Antinociceptive Actions of Botulinum Toxin A1 on Immunogenic Hypersensitivity in Temporomandibular Joint of Rats", Toxins, vol. 14, br. 3, Veljača 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:714770. [Citirano: 29.11.2024.]

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Naslov (engleski)Antinociceptive Actions of Botulinum Toxin A1 on Immunogenic Hypersensitivity in Temporomandibular Joint of Rats
AutorVictor Ricardo Manuel Muñoz-Lora
AutorAna Dugonjić Okroša
AutorIvica Matak
AutorAltair Antoninha Del Bel Cury
AutorMikhail Kalinichev
AutorZdravko Lacković
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Sažetak (engleski)
Botulinum neurotoxin type A1 (BoNT-A) reduces the peripheral peptide and cytokine upregulation in rats with antigen-evoked persistent immunogenic hypersensitivity (PIH) of the temporomandibular joint (TMJ). Herein, we examined the effects of two preparations of BoNT-A, abobotulinumtoxinA (aboBoNT-A; Dysport) and onabotulinumtoxinA (onaBoNT-A; Botox), on spontaneous and evoked nociceptive behaviors, as well as on central neuronal and astroglial activation. The antigen-evoked PIH was induced in rats via repeated systemic and unilateral intra-articular (i.a.) injections of methylated bovine serum albumin (mBSA). Rats were subsequently injected with unilateral i.a. aboBoNT-A (14 U/kg), onaBoNT-A (7 U/kg), or the vehicle (saline). After i.a. treatments, spontaneous and mechanically evoked nocifensive behaviors were assessed before and after the low-dose i.a. formalin (0.5%) challenge. The central effects of BoNT-A were assessed by an immunohistochemical analysis of cleaved synaptosomal-associated protein 25 (cSNAP-25) presence, c-Fos, GFAP, and CGRP expression in the trigeminal nucleus caudalis (TNC). Both BoNT-A preparations similarly reduced the formalin-induced spontaneous pain-related behaviors and mechanical allodynia of the hypernociceptive rats. Likewise, their effects were associated with the central occurrence of cSNAP-25 and reduction of c-Fos and GFAP upregulation in the TNC. BoNT-A antinociceptive activity on the PIH is associated with the toxin axonal transport to trigeminal sensory areas and reduction of neuronal and glial activation in central nociceptive regions.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaToxins
Brojčani podacivol. 14, br. 3, 161
e-ISSN2072-6651
DOIhttps://doi.org/10.3390/toxins14030161
URN:NBNurn:nbn:hr:105:714770
Datum objave publikacije2022-02-23
URL dokumentahttps://www.mdpi.com/2072-6651/14/3/161
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-09-28 09:42:12