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The Signature of Moderate Perinatal Hypoxia on Cortical Organization and Behavior: Altered PNN-Parvalbumin Interneuron Connectivity of the Cingulate Circuitries
Frontiers in Cell and Developmental Biology, 10 (2022); 810980. https://doi.org/10.3389/fcell.2022.810980
Trnski, Sara; Nikolić, Barbara; Ilić, Katarina; Drlje, Matea; Bobić-Rasonja, Mihaela; Darmopil, Sanja; Petanjek, Zdravko; Hranilović, Dubravka; Jovanov-Milošević, Nataša

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Trnski, S., Nikolić, B., Ilić, K., Drlje, M., Bobić Rasonja, M., Darmopil, S. ... Jovanov Milošević, N. (2022). The Signature of Moderate Perinatal Hypoxia on Cortical Organization and Behavior: Altered PNN-Parvalbumin Interneuron Connectivity of the Cingulate Circuitries. Frontiers in Cell and Developmental Biology, 10.. doi: 10.3389/fcell.2022.810980

Trnski, Sara, et al. "The Signature of Moderate Perinatal Hypoxia on Cortical Organization and Behavior: Altered PNN-Parvalbumin Interneuron Connectivity of the Cingulate Circuitries." Frontiers in Cell and Developmental Biology, vol. 10, 2022. https://doi.org/10.3389/fcell.2022.810980

Trnski, Sara, Barbara Nikolić, Katarina Ilić, Matea Drlje, Mihaela Bobić Rasonja, Sanja Darmopil, Zdravko Petanjek, Dubravka Hranilović i Nataša Jovanov Milošević. "The Signature of Moderate Perinatal Hypoxia on Cortical Organization and Behavior: Altered PNN-Parvalbumin Interneuron Connectivity of the Cingulate Circuitries." Frontiers in Cell and Developmental Biology 10 (2022). https://doi.org/10.3389/fcell.2022.810980

Trnski, S., et al. (2022) 'The Signature of Moderate Perinatal Hypoxia on Cortical Organization and Behavior: Altered PNN-Parvalbumin Interneuron Connectivity of the Cingulate Circuitries', Frontiers in Cell and Developmental Biology, 10. doi: 10.3389/fcell.2022.810980

Trnski S, Nikolić B, Ilić K, Drlje M, Bobić Rasonja M, Darmopil S, i sur.. The Signature of Moderate Perinatal Hypoxia on Cortical Organization and Behavior: Altered PNN-Parvalbumin Interneuron Connectivity of the Cingulate Circuitries. Frontiers in Cell and Developmental Biology [Internet]. 28.02.2022. [pristupljeno 13.04.2024.];10. doi: 10.3389/fcell.2022.810980

S. Trnski, et al., "The Signature of Moderate Perinatal Hypoxia on Cortical Organization and Behavior: Altered PNN-Parvalbumin Interneuron Connectivity of the Cingulate Circuitries", Frontiers in Cell and Developmental Biology, vol. 10, Veljača 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:176415. [Citirano: 13.04.2024.]

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Podaci o radu
Naslov (engleski)The Signature of Moderate Perinatal Hypoxia on Cortical Organization and Behavior: Altered PNN-Parvalbumin Interneuron Connectivity of the Cingulate Circuitries
AutorSara Trnski
AutorBarbara Nikolić
AutorKatarina Ilić
AutorMatea Drlje
AutorMihaela Bobić-Rasonja
AutorSanja Darmopil
AutorZdravko Petanjek
AutorDubravka Hranilović
AutorNataša Jovanov-Milošević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ANATOMIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU BIOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Sažetak (engleski)
This study was designed in a rat model to determine the hallmarks of possible permanent behavioral and structural brain alterations after a single moderate hypoxic insult. Eighty-two Wistar Han (RccHan: WIST) rats were randomly subjected to hypoxia (pO2 73 mmHg/2 h) or normoxia at the first postnatal day. The substantially increased blood lactate, a significantly decreased cytochrome-C-oxygenase expression in the brain, and depleted subventricular zone suggested a high vulnerability of subset of cell populations to oxidative stress and consequent tissue response even after a single, moderate, hypoxic event. The results of behavioral tests (open-field, hole-board, social-choice, and T-maze) applied at the 30–45th and 70–85th postnatal days revealed significant hyperactivity and a slower pace of learning in rats subjected to perinatal hypoxia. At 3.5 months after hypoxic insult, the histochemical examination demonstrated a significantly increased number of specific extracellular matrix—perineuronal nets and increased parvalbumin expression in a subpopulation of interneurons in the medial and retrosplenial cingulate cortex of these animals. Conclusively, moderate perinatal hypoxia in rats causes a long-lasting reorganization of the connectivity in the cingulate cortex and consequent alterations of related behavioral and cognitive abilities. This non-invasive hypoxia model in the rat successfully and complementarily models the moderate perinatal hypoxic injury in fetuses and prematurely born human babies and may enhance future research into new diagnostic and therapeutic strategies for perinatal medicine.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFrontiers in Cell and Developmental Biology
Brojčani podacivol. 10, 810980
e-ISSN2296-634X
DOIhttps://doi.org/10.3389/fcell.2022.810980
URN:NBNurn:nbn:hr:105:176415
Datum objave publikacije2022-02-28
URL dokumentahttps://www.frontiersin.org/articles/10.3389/fcell.2022.810980/full
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-09-30 10:49:20