prikaz prve stranice dokumenta Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate
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Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate
Nature Communications, 13 (2022), 1; 633. https://doi.org/10.1038/s41467-021-27602-z
Parichha, Arpan; Suresh, Varun; Chatterjee, Mallika; Kshirsagar, Aditya; Ben-Reuven, Lihi; Olender, Tsviya; Taketo, M. Mark; Radošević, Velena; Bobić-Rasonja, Mihaela; Trnski, Sara; Holtzman, Michael J.; Jovanov-Milošević, Nataša; Reiner, Orly; Tole, Shubha

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Parichha, A., Suresh, V., Chatterjee, M., Kshirsagar, A., Ben Reuven, L., Olender, T. ... Tole, S. (2022). Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate. Nature Communications, 13. (1). doi: 10.1038/s41467-021-27602-z

Parichha, Arpan, et al. "Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate." Nature Communications, vol. 13, br. 1, 2022. https://doi.org/10.1038/s41467-021-27602-z

Parichha, Arpan, Varun Suresh, Mallika Chatterjee, Aditya Kshirsagar, Lihi Ben Reuven, Tsviya Olender, M. Mark Taketo, et al. "Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate." Nature Communications 13, br. 1 (2022). https://doi.org/10.1038/s41467-021-27602-z

Parichha, A., et al. (2022) 'Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate', Nature Communications, 13(1). doi: 10.1038/s41467-021-27602-z

Parichha A, Suresh V, Chatterjee M, Kshirsagar A, Ben Reuven L, Olender T, i sur.. Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate. Nature Communications [Internet]. 02.2022. [pristupljeno 15.04.2024.];13(1). doi: 10.1038/s41467-021-27602-z

A. Parichha, et al., "Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate", Nature Communications, vol. 13, br. 1, Veljača 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:947172. [Citirano: 15.04.2024.]

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Naslov (engleski)Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate
AutorArpan Parichha
AutorVarun Suresh
AutorMallika Chatterjee
AutorAditya Kshirsagar
AutorLihi Ben-Reuven
AutorTsviya Olender
AutorM. Mark Taketo
AutorVelena Radošević
AutorMihaela Bobić-Rasonja
AutorSara Trnski
AutorMichael J. Holtzman
AutorNataša Jovanov-Milošević
AutorOrly Reiner
AutorShubha Tole
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU BIOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Sažetak (engleski)
The choroid plexus secretes cerebrospinal fluid and is critical for the development and function of the brain. In the telencephalon, the choroid plexus epithelium arises from the Wnt- expressing cortical hem. Canonical Wnt signaling pathway molecules such as nuclear β-CATENIN are expressed in the mouse and human embryonic choroid plexus epithelium indicating that this pathway is active. Point mutations in human β-CATENIN are known to result in the constitutive activation of canonical Wnt signaling. In a mouse model that recapitulates this perturbation, we report a loss of choroid plexus epithelial identity and an apparent transformation of this tissue to a neuronal identity. Aspects of this phenomenon are recapitulated in human embryonic stem cell derived organoids. The choroid plexus is also disrupted when β-Catenin is conditionally inactivated. Together, our results indicate that canonical Wnt signaling is required in a precise and regulated manner for normal choroid plexus development in the mammalian brain.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNature Communications
Brojčani podacivol. 13, br. 1, 633
e-ISSN2041-1723
DOIhttps://doi.org/10.1038/s41467-021-27602-z
URN:NBNurn:nbn:hr:105:947172
Datum objave publikacije2022-02
URL dokumentahttps://www.nature.com/articles/s41467-021-27602-z
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-11-14 10:21:51