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DOAC Dipstick Testing Can Reliably Exclude the Presence of Clinically Relevant DOAC Concentrations in Circulation
Thrombosis and Haemostasis, 122 (2022), 9; 1542-1548. https://doi.org/10.1055/a-1753-2748
Margetić, Sandra; Ćelap, Ivana; Lovrenčić Huzjan, Arijana; Bosnar Puretić, Marijana; Šupraha Goreta, Sandra; Glojnarić, Anesa Čajević; Delić Brkljačić, Diana; Mioč, Pavao; Harenberg, Job; Hetjens, Svetlana; Weiss, Christel

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Margetić, S., Ćelap, I., Lovrenčić Huzjan, A., Bosnar Puretić, M., Šupraha Goreta, S., Glojnarić, A. Č. ... Weiss, C. (2022). DOAC Dipstick Testing Can Reliably Exclude the Presence of Clinically Relevant DOAC Concentrations in Circulation. Thrombosis and Haemostasis, 122. (9), 1542-1548. doi: 10.1055/a-1753-2748

Margetić, Sandra, et al. "DOAC Dipstick Testing Can Reliably Exclude the Presence of Clinically Relevant DOAC Concentrations in Circulation." Thrombosis and Haemostasis, vol. 122, br. 9, 2022, str. 1542-1548. https://doi.org/10.1055/a-1753-2748

Margetić, Sandra, Ivana Ćelap, Arijana Lovrenčić Huzjan, Marijana Bosnar Puretić, Sandra Šupraha Goreta, Anesa Čajević Glojnarić, Diana Delić Brkljačić, et al. "DOAC Dipstick Testing Can Reliably Exclude the Presence of Clinically Relevant DOAC Concentrations in Circulation." Thrombosis and Haemostasis 122, br. 9 (2022): 1542-1548. https://doi.org/10.1055/a-1753-2748

Margetić, S., et al. (2022) 'DOAC Dipstick Testing Can Reliably Exclude the Presence of Clinically Relevant DOAC Concentrations in Circulation', Thrombosis and Haemostasis, 122(9), str. 1542-1548. doi: 10.1055/a-1753-2748

Margetić S, Ćelap I, Lovrenčić Huzjan A, Bosnar Puretić M, Šupraha Goreta S, Glojnarić AČ, i sur.. DOAC Dipstick Testing Can Reliably Exclude the Presence of Clinically Relevant DOAC Concentrations in Circulation. Thrombosis and Haemostasis [Internet]. 09.2022. [pristupljeno 16.04.2024.];122(9):1542-1548. doi: 10.1055/a-1753-2748

S. Margetić, et al., "DOAC Dipstick Testing Can Reliably Exclude the Presence of Clinically Relevant DOAC Concentrations in Circulation", Thrombosis and Haemostasis, vol. 122, br. 9, str. 1542-1548, Rujan 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:863334. [Citirano: 16.04.2024.]

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Naslov (engleski)DOAC Dipstick Testing Can Reliably Exclude the Presence of Clinically Relevant DOAC Concentrations in Circulation
AutorSandra Margetić
AutorIvana Ćelap
AutorArijana Lovrenčić Huzjan
AutorMarijana Bosnar Puretić
AutorSandra Šupraha Goreta
AutorAnesa Čajević Glojnarić
AutorDiana Delić Brkljačić
AutorPavao Mioč
AutorJob Harenberg
AutorSvetlana Hetjens
AutorChristel Weiss
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
In certain clinical situations, it is necessary to determine whether clinically relevant plasma levels of direct oral anticoagulants (DOACs) are present. We examined whether qualitative testing of DOACs in urine samples can exclude DOAC plasma concentrations of ≥30 ng/mL. This prospective single-center cohort study included consecutive patients treated with an oral direct factor Xa inhibitor (DXI) (apixaban, n = 31, rivaroxaban, n = 53) and direct thrombin inhibitor (DTI) (dabigatran, n = 44). We aimed to define the negative predictive value (NPV) and other statistical parameters of detecting DXIs and DTIs by DOAC Dipstick at plasma concentrations of ≥30 ng/mL. We also determined the best-fit threshold plasma levels using chromogenic substrate assays by logistic regression analysis. Between July 2020 and July 2021, 128 eligible patients (mean age 66 years, 55 females) were included into the study. The NPVs and sensitivities for DXI and DTI of DOAC Dipstick were 100% at ≥30 ng/mL plasma, for specificities 6 and 21% and for positive predictive values 62 and 72%, respectively. All diagnostic statistical tests improved to values between 86 and 100% at best-fitting plasma thresholds of ≥14 ng/mL for DXI and ≥19 ng/mL for DTI. Visual analysis using the DOAC Dipstick was 100% in agreement with that of the optoelectronic DOASENSE Reader for all the three DOACs. DOAC Dipstick testing can reliably exclude the presence of DOACs in urine samples at best-fitting thresholds of >14 and >19 ng/mL in plasma. The performance of the DOAC Dipstick at detecting lower DOAC concentrations in plasma requires confirmation.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaThrombosis and Haemostasis
Brojčani podacivol. 122, br. 9, str. 1542-1548
p-ISSN0340-6245
e-ISSN2567-689X
DOIhttps://doi.org/10.1055/a-1753-2748
URN:NBNurn:nbn:hr:105:863334
Datum objave publikacije2022-09
ProjektŠifra: IP-2016-06-8208
Naziv (hrvatski): Novi oralni antikoagulansi: povezanost koncentracije lijeka i antikoagulantnog učinka
Kratica: LAB-NOAC
Voditelj: Sandra Margetić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
URL dokumentahttp://www.thieme-connect.de/DOI/DOI?10.1055/a-1753-2748
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2022-11-14 12:21:48