prikaz prve stranice dokumenta A Variant Carbapenem Inactivation Method (CIM) for Acinetobacter baumannii Group with Shortened Time-to-Result: rCIM-A
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A Variant Carbapenem Inactivation Method (CIM) for Acinetobacter baumannii Group with Shortened Time-to-Result: rCIM-A
Pathogens, 11 (2022), 4; 482. https://doi.org/10.3390/pathogens11040482
Mitteregger, Dieter; Wessely, Julian; Barišić, Ivan; Bedenić, Branka; Kosak, Dieter; Kundi, Michael

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Mitteregger, D., Wessely, J., Barišić, I., Bedenić, B., Kosak, D. i Kundi, M. (2022). A Variant Carbapenem Inactivation Method (CIM) for Acinetobacter baumannii Group with Shortened Time-to-Result: rCIM-A. Pathogens, 11. (4). doi: 10.3390/pathogens11040482

Mitteregger, Dieter, et al. "A Variant Carbapenem Inactivation Method (CIM) for Acinetobacter baumannii Group with Shortened Time-to-Result: rCIM-A." Pathogens, vol. 11, br. 4, 2022. https://doi.org/10.3390/pathogens11040482

Mitteregger, Dieter, Julian Wessely, Ivan Barišić, Branka Bedenić, Dieter Kosak i Michael Kundi. "A Variant Carbapenem Inactivation Method (CIM) for Acinetobacter baumannii Group with Shortened Time-to-Result: rCIM-A." Pathogens 11, br. 4 (2022). https://doi.org/10.3390/pathogens11040482

Mitteregger, D., et al. (2022) 'A Variant Carbapenem Inactivation Method (CIM) for Acinetobacter baumannii Group with Shortened Time-to-Result: rCIM-A', Pathogens, 11(4). doi: 10.3390/pathogens11040482

Mitteregger D, Wessely J, Barišić I, Bedenić B, Kosak D, Kundi M. A Variant Carbapenem Inactivation Method (CIM) for Acinetobacter baumannii Group with Shortened Time-to-Result: rCIM-A. Pathogens [Internet]. 18.04.2022. [pristupljeno 08.11.2024.];11(4). doi: 10.3390/pathogens11040482

D. Mitteregger, J. Wessely, I. Barišić, B. Bedenić, D. Kosak i M. Kundi, "A Variant Carbapenem Inactivation Method (CIM) for Acinetobacter baumannii Group with Shortened Time-to-Result: rCIM-A", Pathogens, vol. 11, br. 4, Travanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:048963. [Citirano: 08.11.2024.]

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Naslov (engleski)A Variant Carbapenem Inactivation Method (CIM) for Acinetobacter baumannii Group with Shortened Time-to-Result: rCIM-A
AutorDieter Mitteregger
AutorJulian Wessely
AutorIvan Barišić
AutorBranka Bedenić
AutorDieter Kosak
AutorMichael Kundi
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU MIKROBIOLOGIJU I PARAZITOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Medicinska mikrobiologija
Sažetak (engleski)
Carbapenem-resistant Acinetobacter baumannii group organisms (CRAB) are challenging because the choice between targeted, new antibiotic drug options and hygiene measures should be guided by a timely identification of resistance mechanisms. In CRAB, acquired class-D carbapenemases (CHDLs) are active against meropenem and imipenem. If PCR methods are not the first choice, phenotypic methods have to be implemented. While promising, the carbapenemase inactivation method (CIM) using meropenem-hydrolysis is, however, hampered by poor performance or overly long time-to-result. We developed a rapid CIM (rCIM-A) with good performance using ertapenem, imipenem, and meropenem disks, 2-h permeabilization and incubation with the test strain in trypticase soy broth, and a read-out of residual carbapenem activity after 6 h, and optionally after 16–18 h. Using clinical isolates and type-strains of Acinetobacter (n = 67) not harboring carbapenemases (n = 28) or harboring acquired carbapenemases (n = 39), the sensitivity of detection was 97.4% with the imipenem disk after 6 h at a specificity of 92.9%. If the inhibition zone around the ertapenem disk at 6 h was 6 or ≤26 mm at 16–18 h, or ≤25.5 mm for meropenem, the specificity was 100%. Because of the high negative predictive value, the rCIM-A seems particularly appropriate in areas of lower CRAB-frequency.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPathogens
Brojčani podacivol. 11, br. 4, 482
e-ISSN2076-0817
DOIhttps://doi.org/10.3390/pathogens11040482
URN:NBNurn:nbn:hr:105:048963
Datum objave publikacije2022-04-18
URL dokumentahttps://www.mdpi.com/2076-0817/11/4/482
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-12-12 08:10:47