Lymphocytic choriomeningitis virus: An under-recognized congenital teratogen

Znanstveni rad - Prikaz slučaja

• Autor: Thomas Ferenc
• Autor: Mateja Vujica
• Autor: Anna Mrzljak
• Autor: Tatjana Vilibić-Čavlek
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA INTERNU MEDICINU)
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA MEDICINSKU MIKROBIOLOGIJU I PARAZITOLOGIJU)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Interna medicina
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Medicinska mikrobiologija

Sažetak (engleski)

Background: Lymphocytic choriomeningitis virus (LCMV) is a neglected rodent-borne arenavirus associated with transplacental transmission and fetal infection.
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Aim: To summarize the epidemiological, clinical, and diagnostic features of reported patients with congenital LCMV infection.
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Methods: A literature search was conducted in PubMed, Medline, Google Scholar, and ResearchGate. The keywords used were 'congenital lymphocytic choriomeningitis virus,' and 48 studies were included. In addition, we conducted a relevant search by Reference Citation Analysis (RCA) (https://www.referencecitationanalysis.com).
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Results: The results have shown 27 reports of congenital LCMV infection in 86 patients, with 52.73% of them being males. Patients presented with chorioretinitis (83.53%), hydrocephalus (54.12%), and psychomotor retardation or developmental delay (54.12%). Computed tomography and/or magnetic resonance imaging most often demonstrated ventriculomegaly (74.07%), periventricular calcifications (66.67%), and microcephaly (40%). Most mothers of congenitally infected infants were exposed to rodents during pregnancy, predominantly mice, with flu-like symptoms mainly occurring during the first two trimesters of gestation. Mortality in congenitally infected children was 16.47%. The diagnosis of congenital LCMV infection was confirmed serologically in most patients (86.67%).
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Conclusion: LCMV is still an insufficiently recognized fetal teratogen that often leads to long-term neurologic sequelae. Clinicians need to be familiar with LCMV and its potential teratogenic effect and as well as to effectively differentiate LCMV from other TORCH (T: Toxoplasma gondii, O: Other pathogens, R: Rubella virus, C: Cytomegalovirus, H: Herpes simplex virus) pathogens.

• Ključne riječi (engleski): Congenital infection; Epidemiology; Lymphocytic choriomeningitis virus; Pregnancy; TORCH
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Prikaz slučaja
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: World Journal of Clinical Cases
• Brojčani podaci: vol. 10, br. 25, str. 8922-8931
• p-ISSN: 2307-8960
• DOI: https://doi.org/10.12998/wjcc.v10.i25.8922
• URN:NBN: urn:nbn:hr:105:512708
• Datum objave publikacije: 2022
• URL dokumenta: https://www.wjgnet.com/2307-8960/full/v10/i25/8922.htm
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2023-02-10 10:17:40