prikaz prve stranice dokumenta TLR5 Variants Are Associated with the Risk for COPD and NSCLC Development, Better Overall Survival of the NSCLC Patients and Increased Chemosensitivity in the H1299 Cell Line
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TLR5 Variants Are Associated with the Risk for COPD and NSCLC Development, Better Overall Survival of the NSCLC Patients and Increased Chemosensitivity in the H1299 Cell Line
Biomedicines, 10 (2022), 9; 2240. https://doi.org/10.3390/biomedicines10092240
Baranašić, Jurica; Šutić, Maja; Catalano, Calogerina; Drpa, Gordana; Huhn, Stefanie; Majhen, Dragomira; Nestić, Davor; Kurtović, Matea; Rumora, Lada; Bosnar, Martina; Vukić Dugac, Andrea; Sokolović, Irena; Popović-Grle, Sanja; Oršolić, Nada; Škrinjarić-Cincar, Sanda; Jakopović, Marko; Samaržija, Miroslav; Weber, Alexander N. R.; Försti, Asta; Knežević, Jelena Više autora...

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Baranašić, J., Šutić, M., Catalano, C., Drpa, G., Huhn, S., Majhen, D. ... Knežević, J. (2022). TLR5 Variants Are Associated with the Risk for COPD and NSCLC Development, Better Overall Survival of the NSCLC Patients and Increased Chemosensitivity in the H1299 Cell Line. Biomedicines, 10. (9). doi: 10.3390/biomedicines10092240

Baranašić, Jurica, et al. "TLR5 Variants Are Associated with the Risk for COPD and NSCLC Development, Better Overall Survival of the NSCLC Patients and Increased Chemosensitivity in the H1299 Cell Line." Biomedicines, vol. 10, br. 9, 2022. https://doi.org/10.3390/biomedicines10092240

Baranašić, Jurica, Maja Šutić, Calogerina Catalano, Gordana Drpa, Stefanie Huhn, Dragomira Majhen, Davor Nestić, et al. "TLR5 Variants Are Associated with the Risk for COPD and NSCLC Development, Better Overall Survival of the NSCLC Patients and Increased Chemosensitivity in the H1299 Cell Line." Biomedicines 10, br. 9 (2022). https://doi.org/10.3390/biomedicines10092240

Baranašić, J., et al. (2022) 'TLR5 Variants Are Associated with the Risk for COPD and NSCLC Development, Better Overall Survival of the NSCLC Patients and Increased Chemosensitivity in the H1299 Cell Line', Biomedicines, 10(9). doi: 10.3390/biomedicines10092240

Baranašić J, Šutić M, Catalano C, Drpa G, Huhn S, Majhen D, i sur.. TLR5 Variants Are Associated with the Risk for COPD and NSCLC Development, Better Overall Survival of the NSCLC Patients and Increased Chemosensitivity in the H1299 Cell Line. Biomedicines [Internet]. 09.09.2022. [pristupljeno 12.04.2024.];10(9). doi: 10.3390/biomedicines10092240

J. Baranašić, et al., "TLR5 Variants Are Associated with the Risk for COPD and NSCLC Development, Better Overall Survival of the NSCLC Patients and Increased Chemosensitivity in the H1299 Cell Line", Biomedicines, vol. 10, br. 9, Rujan 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:605296. [Citirano: 12.04.2024.]

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Naslov (engleski)TLR5 Variants Are Associated with the Risk for COPD and NSCLC Development, Better Overall Survival of the NSCLC Patients and Increased Chemosensitivity in the H1299 Cell Line
AutorJurica Baranašić
AutorMaja Šutić
AutorCalogerina Catalano
AutorGordana Drpa
AutorStefanie Huhn
AutorDragomira Majhen
AutorDavor Nestić
AutorMatea Kurtović
AutorLada Rumora
AutorMartina Bosnar
AutorAndrea Vukić Dugac
AutorIrena Sokolović
AutorSanja Popović-Grle
AutorNada Oršolić
AutorSanda Škrinjarić-Cincar
AutorMarko Jakopović
AutorMiroslav Samaržija
AutorAlexander N. R. Weber
AutorAsta Försti
AutorJelena Knežević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Chronic obstructive pulmonary disease (COPD) is considered as the strongest independent risk factor for lung cancer (LC) development, suggesting an overlapping genetic background in both diseases. A common feature of both diseases is aberrant immunity in respiratory epithelia that is mainly regulated by Toll-like receptors (TLRs), key regulators of innate immunity. The function of the flagellin-sensing TLR5 in airway epithelia and pathophysiology of COPD and LC has remained elusive. We performed case–control genetic association and functional studies on the importance of TLR5 in COPD and LC development, comparing Caucasian COPD/LC patients (n = 974) and healthy donors (n = 1283). Association analysis of three single nucleotide polymorphisms (SNPs) (rs725084, rs2072493_N592S, and rs5744174_F616L) indicated the minor allele of rs2072493_N592S to be associated with increased risk for COPD (OR = 4.41, p < 0.0001) and NSCLC (OR = 5.17, p < 0.0001) development and non-small cell LC risk in the presence of COPD (OR = 1.75, p = 0.0031). The presence of minor alleles (rs5744174 and rs725084) in a co-dominant model was associated with overall survival in squamous cell LC patients. Functional analysis indicated that overexpression of the rs2072493_N592S allele affected the activation of NF-κB and AP-1, which could be attributed to impaired phosphorylation of p38 and ERK. Overexpression of TLR5N592S was associated with increased chemosensitivity in the H1299 cell line. Finally, genome-wide transcriptomic analysis on WI-38 and H1299 cells overexpressing TLR5WT or TLR5N592S, respectively, indicated the existence of different transcription profiles affecting several cellular pathways potentially associated with a dysregulated immune response. Our results suggest that TLR5 could be recognized as a potential biomarker for COPD and LC development with functional relevance.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedicines
Brojčani podacivol. 10, br. 9, 2240
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines10092240
URN:NBNurn:nbn:hr:105:605296
Datum objave publikacije2022-09-09
ProjektŠifra: IP-2016-06-1441
Naziv (hrvatski): Genetički i epigenetički biomarkeri urođene imunosti u KOPB-u i karcinomu pluća
Kratica: LungInflaCare
Voditelj: Jelena Knežević
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
ProjektŠifra: IP-2014-09-1247
Naziv (hrvatski): Uloga stresnog proteina Hsp70 u imunosno-upalnom odgovoru kod kronične opstrukcijske plućne bolesti
Naziv (engleski): The role of stress protein Hsp70 in immune and inflammatory responses in chronic obstructive pulmonary disease
Kratica: Hsp70COPD
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
URL dokumentahttps://www.mdpi.com/2227-9059/10/9/2240
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-02-13 12:38:37