prikaz prve stranice dokumenta The Effect of Treatment-Induced Viral Eradication on Cytokine and Growth Factor Expression in Chronic Hepatitis C
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The Effect of Treatment-Induced Viral Eradication on Cytokine and Growth Factor Expression in Chronic Hepatitis C
Viruses, 14 (2022), 8; 1613. https://doi.org/10.3390/v14081613
Radmanić, Leona; Bodulić, Kristian; Šimičić, Petra; Vince, Adriana; Židovec Lepej, Snježana

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Radmanić, L., Bodulić, K., Šimičić, P., Vince, A. i Židovec Lepej, S. (2022). The Effect of Treatment-Induced Viral Eradication on Cytokine and Growth Factor Expression in Chronic Hepatitis C. Viruses, 14. (8). doi: 10.3390/v14081613

Radmanić, Leona, et al. "The Effect of Treatment-Induced Viral Eradication on Cytokine and Growth Factor Expression in Chronic Hepatitis C." Viruses, vol. 14, br. 8, 2022. https://doi.org/10.3390/v14081613

Radmanić, Leona, Kristian Bodulić, Petra Šimičić, Adriana Vince i Snježana Židovec Lepej. "The Effect of Treatment-Induced Viral Eradication on Cytokine and Growth Factor Expression in Chronic Hepatitis C." Viruses 14, br. 8 (2022). https://doi.org/10.3390/v14081613

Radmanić, L., et al. (2022) 'The Effect of Treatment-Induced Viral Eradication on Cytokine and Growth Factor Expression in Chronic Hepatitis C', Viruses, 14(8). doi: 10.3390/v14081613

Radmanić L, Bodulić K, Šimičić P, Vince A, Židovec Lepej S. The Effect of Treatment-Induced Viral Eradication on Cytokine and Growth Factor Expression in Chronic Hepatitis C. Viruses [Internet]. 24.07.2022. [pristupljeno 12.04.2024.];14(8). doi: 10.3390/v14081613

L. Radmanić, K. Bodulić, P. Šimičić, A. Vince i S. Židovec Lepej, "The Effect of Treatment-Induced Viral Eradication on Cytokine and Growth Factor Expression in Chronic Hepatitis C", Viruses, vol. 14, br. 8, Srpanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:625533. [Citirano: 12.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:625533
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Podaci o radu
Naslov (engleski)The Effect of Treatment-Induced Viral Eradication on Cytokine and Growth Factor Expression in Chronic Hepatitis C
AutorLeona Radmanić
AutorKristian Bodulić
AutorPetra Šimičić
AutorAdriana Vince
AutorSnježana Židovec Lepej
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INFEKTOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Infektologija
Sažetak (engleski)
In this study, we evaluated the effect of hepatitis C virus eradication using direct-acting antivirals (DAA) on the serum cytokine and growth factor profiles of chronic hepatitis C patients (CHC). Serum concentrations of 12 cytokines and 13 growth factors were measured in 56 patients with CHC before, during the DAA treatment and after sustained virological response using bead-based flow cytometry. Cytokine and growth factor levels were also measured in 15 healthy individuals. The majority of the selected cytokines and growth factors exhibited similar concentrations before, during and after successful DAA treatment, the exceptions being IL-10, EGF, HGF and VEGF. Significantly lower concentrations of IL-10, IL-13, IL-4, IL-4, IL-9, TNF- α and higher levels of Ang-2, HGF and SCF were observed in patients with CHC before and after DAA treatment compared with healthy individuals. Patients with severe fibrosis stages exhibited higher levels of Ang-2 and lower levels of EGF, PDGF-AA and VEGF. Furthermore, IL-4, IL-5 and SCF were characterized as potential biomarkers of DAA treatment using random forest. Additionally, logistic regression characterized EGF as a potential biomarker of severe CHC. Our results suggest inhibition of pro-inflammatory processes and promotion of liver regeneration in CHC patients during DAA treatment.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaViruses
Brojčani podacivol. 14, br. 8, 1613
e-ISSN1999-4915
DOIhttps://doi.org/10.3390/v14081613
URN:NBNurn:nbn:hr:105:625533
Datum objave publikacije2022-07-24
URL dokumentahttps://www.mdpi.com/1999-4915/14/8/1613
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-03-07 08:06:52