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Distribution of Pathogens and Predictive Values of Biomarkers of Inflammatory Response at ICU Admission on Outcomes of Critically Ill COVID-19 Patients with Bacterial Superinfections—Observations from National COVID-19 Hospital in Croatia
Diagnostics, 12 (2022), 9; 2069. https://doi.org/10.3390/diagnostics12092069
Ćurčić, Maja; Tarle, Marko; Almahariq, Hani; Hleb, Sonja; Havaš, Juraj; Pražetina, Marko; Lasić, Hrvoje; Dolenc, Emil; Kukoč, Andrea; Mihelčić, Antonija; Miko, Ivan; Romić, Andrea; Tipura, Danijela; Drmić, Željka; Čučković, Marcela; Blagaj, Vanja; Lukšić, Ivica; Peršec, Jasminka; Šribar, Andrej Više autora...

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Ćurčić, M., Tarle, M., Almahariq, H., Hleb, S., Havaš, J., Pražetina, M. ... Šribar, A. (2022). Distribution of Pathogens and Predictive Values of Biomarkers of Inflammatory Response at ICU Admission on Outcomes of Critically Ill COVID-19 Patients with Bacterial Superinfections—Observations from National COVID-19 Hospital in Croatia. Diagnostics, 12. (9). doi: 10.3390/diagnostics12092069

Ćurčić, Maja, et al. "Distribution of Pathogens and Predictive Values of Biomarkers of Inflammatory Response at ICU Admission on Outcomes of Critically Ill COVID-19 Patients with Bacterial Superinfections—Observations from National COVID-19 Hospital in Croatia." Diagnostics, vol. 12, br. 9, 2022. https://doi.org/10.3390/diagnostics12092069

Ćurčić, Maja, Marko Tarle, Hani Almahariq, Sonja Hleb, Juraj Havaš, Marko Pražetina, Hrvoje Lasić, et al. "Distribution of Pathogens and Predictive Values of Biomarkers of Inflammatory Response at ICU Admission on Outcomes of Critically Ill COVID-19 Patients with Bacterial Superinfections—Observations from National COVID-19 Hospital in Croatia." Diagnostics 12, br. 9 (2022). https://doi.org/10.3390/diagnostics12092069

Ćurčić, M., et al. (2022) 'Distribution of Pathogens and Predictive Values of Biomarkers of Inflammatory Response at ICU Admission on Outcomes of Critically Ill COVID-19 Patients with Bacterial Superinfections—Observations from National COVID-19 Hospital in Croatia', Diagnostics, 12(9). doi: 10.3390/diagnostics12092069

Ćurčić M, Tarle M, Almahariq H, Hleb S, Havaš J, Pražetina M, i sur.. Distribution of Pathogens and Predictive Values of Biomarkers of Inflammatory Response at ICU Admission on Outcomes of Critically Ill COVID-19 Patients with Bacterial Superinfections—Observations from National COVID-19 Hospital in Croatia. Diagnostics [Internet]. 26.08.2022. [pristupljeno 08.11.2024.];12(9). doi: 10.3390/diagnostics12092069

M. Ćurčić, et al., "Distribution of Pathogens and Predictive Values of Biomarkers of Inflammatory Response at ICU Admission on Outcomes of Critically Ill COVID-19 Patients with Bacterial Superinfections—Observations from National COVID-19 Hospital in Croatia", Diagnostics, vol. 12, br. 9, Kolovoz 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:974130. [Citirano: 08.11.2024.]

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Naslov (engleski)Distribution of Pathogens and Predictive Values of Biomarkers of Inflammatory Response at ICU Admission on Outcomes of Critically Ill COVID-19 Patients with Bacterial Superinfections—Observations from National COVID-19 Hospital in Croatia
AutorMaja Ćurčić
AutorMarko Tarle
AutorHani Almahariq
AutorSonja Hleb
AutorJuraj Havaš
AutorMarko Pražetina
AutorHrvoje Lasić
AutorEmil Dolenc
AutorAndrea Kukoč
AutorAntonija Mihelčić
AutorIvan Miko
AutorAndrea Romić
AutorDanijela Tipura
AutorŽeljka Drmić
AutorMarcela Čučković
AutorVanja Blagaj
AutorIvica Lukšić
AutorJasminka Peršec
AutorAndrej Šribar
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MAKSILOFACIJALNU KIRURGIJU SA STOMATOLOGIJOM)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Sažetak (engleski)
Background: Superinfections contribute to mortality and length of stay in critically ill COVID-19 patients. The aim of this study was to determine the incidence and pathogen distribution of bacterial and fungal superinfections of the lower respiratory tract (LRTI), urinary tract (UTI) and bloodstream (BSI) and to determine the predictive value of biomarkers of inflammatory response on their ICU survival rates. ----- Methods: A retrospective observational study that included critically ill COVID-19 patients treated during an 11-month period in a Croatian national COVID-19 hospital was performed. Clinical and diagnostic data were analyzed according to the origin of superinfection, and multivariate regression analysis was performed to determine the predictive values of biomarkers of inflammation on their survival rates. ----- Results: 55.3% critically ill COVID-19 patients developed bacterial or fungal superinfections, and LRTI were most common, followed by BSI and UTI. Multidrug-resistant pathogens were the most common causes of LRTI and BSI, while Enterococcus faecalis was the most common pathogen causing UTI. Serum ferritin and neutrophil count were associated with decreased chances of survival in patients with LRTI, and patients with multidrug-resistant isolates had significantly higher mortality rates, coupled with longer ICU stays. ----- Conclusion: The incidence of superinfections in critically ill COVID-19 patients was 55.3%, and multidrug-resistant pathogens were dominant. Elevated ferritin levels and neutrophilia at ICU admission were associated with increased ICU mortality in patients with positive LRTI.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaDiagnostics
Brojčani podacivol. 12, br. 9, 2069
e-ISSN2075-4418
DOIhttps://doi.org/10.3390/diagnostics12092069
URN:NBNurn:nbn:hr:105:974130
Datum objave publikacije2022-08-26
URL dokumentahttps://www.mdpi.com/2075-4418/12/9/2069
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-03-14 08:29:35