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Stage II of Chronic Kidney Disease—A Tipping Point in Disease Progression?
Biomedicines, 10 (2022), 7; 1522. https://doi.org/10.3390/biomedicines10071522
Grgurević, Lovorka; Novak, Ruđer; Salai, Grgur; Hrkač, Stela; Močibob, Marko; Kovačević Vojtušek, Ivana; Laganović, Mario

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Grgurević, L., Novak, R., Salai, G., Hrkač, S., Močibob, M., Kovačević Vojtušek, I. i Laganović, M. (2022). Stage II of Chronic Kidney Disease—A Tipping Point in Disease Progression?. Biomedicines, 10. (7). doi: 10.3390/biomedicines10071522

Grgurević, Lovorka, et al. "Stage II of Chronic Kidney Disease—A Tipping Point in Disease Progression?." Biomedicines, vol. 10, br. 7, 2022. https://doi.org/10.3390/biomedicines10071522

Grgurević, Lovorka, Ruđer Novak, Grgur Salai, Stela Hrkač, Marko Močibob, Ivana Kovačević Vojtušek i Mario Laganović. "Stage II of Chronic Kidney Disease—A Tipping Point in Disease Progression?." Biomedicines 10, br. 7 (2022). https://doi.org/10.3390/biomedicines10071522

Grgurević, L., et al. (2022) 'Stage II of Chronic Kidney Disease—A Tipping Point in Disease Progression?', Biomedicines, 10(7). doi: 10.3390/biomedicines10071522

Grgurević L, Novak R, Salai G, Hrkač S, Močibob M, Kovačević Vojtušek I, i sur.. Stage II of Chronic Kidney Disease—A Tipping Point in Disease Progression?. Biomedicines [Internet]. 27.06.2022. [pristupljeno 19.12.2024.];10(7). doi: 10.3390/biomedicines10071522

L. Grgurević, et al., "Stage II of Chronic Kidney Disease—A Tipping Point in Disease Progression?", Biomedicines, vol. 10, br. 7, Lipanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:556905. [Citirano: 19.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:556905
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Naslov (engleski)Stage II of Chronic Kidney Disease—A Tipping Point in Disease Progression?
AutorLovorka Grgurević
AutorRuđer Novak
AutorGrgur Salai
AutorStela Hrkač
AutorMarko Močibob
AutorIvana Kovačević Vojtušek
AutorMario Laganović
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ANATOMIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Sažetak (engleski)
Chronic kidney disease (CKD) is the progressive loss of renal function. Although advances have been made in understanding the progression of CKD, key molecular events in complex pathophysiological mechanisms that mark each stage of renal failure remain largely unknown. Changes in plasma protein profiles in different disease stages are important for identification of early diagnostic markers and potential therapeutic targets. The goal of this study was to determine the molecular profile of each CKD stage (from 1 to 5), aiming to specifically point out markedly expressed or downregulated proteins. We performed a cross-sectional shotgun-proteomic study of pooled plasma across CKD stages and compared them to healthy controls. After sample pooling and heparin-column purification we analysed proteomes from healthy to CKD stage 1 through 5 participants' plasma by liquid-chromatography/mass-spectrometry. We identified 453 proteins across all study groups. Our results indicate that key events, which may later affect the course of disease progression and the overall pathophysiological background, are most pronounced in CKD stage 2, with an emphasis on inflammation, lipoprotein metabolism, angiogenesis and tissue regeneration. We hypothesize that CKD stage 2 is the tipping point in disease progression and a suitable point in disease course for the development of therapeutic solutions.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedicines
Brojčani podacivol. 10, br. 7, 1522
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines10071522
URN:NBNurn:nbn:hr:105:556905
Datum objave publikacije2022-06-27
ProjektŠifra: KK.01.1.1.01.0008
Naziv (engleski): Reproduktivna i regenerativna medicina - istraživanje novih platformi i potencijala
Voditelj: Ana Katušić Bojanac
Pravna nadležnost: Hrvatska
Financijer: MZO
URL dokumentahttps://www.mdpi.com/2227-9059/10/7/1522
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-03-14 08:42:14