prikaz prve stranice dokumenta Malignant insulinoma: Can we predict the long-term outcomes?
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Malignant insulinoma: Can we predict the long-term outcomes?
World Journal of Clinical Cases, 10 (2022), 16; 5124-5132. https://doi.org/10.12998/wjcc.v10.i16.5124
Cigrovski Berković, Maja; Ulamec, Monika; Marinović, Sonja; Balen, Ivan; Mrzljak, Anna

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Cigrovski Berković, M., Ulamec, M., Marinović, S., Balen, I. i Mrzljak, A. (2022). Malignant insulinoma: Can we predict the long-term outcomes?. World Journal of Clinical Cases, 10. (16), 5124-5132. doi: 10.12998/wjcc.v10.i16.5124

Cigrovski Berković, Maja, et al. "Malignant insulinoma: Can we predict the long-term outcomes?." World Journal of Clinical Cases, vol. 10, br. 16, 2022, str. 5124-5132. https://doi.org/10.12998/wjcc.v10.i16.5124

Cigrovski Berković, Maja, Monika Ulamec, Sonja Marinović, Ivan Balen i Anna Mrzljak. "Malignant insulinoma: Can we predict the long-term outcomes?." World Journal of Clinical Cases 10, br. 16 (2022): 5124-5132. https://doi.org/10.12998/wjcc.v10.i16.5124

Cigrovski Berković, M., et al. (2022) 'Malignant insulinoma: Can we predict the long-term outcomes?', World Journal of Clinical Cases, 10(16), str. 5124-5132. doi: 10.12998/wjcc.v10.i16.5124

Cigrovski Berković M, Ulamec M, Marinović S, Balen I, Mrzljak A. Malignant insulinoma: Can we predict the long-term outcomes?. World Journal of Clinical Cases [Internet]. 2022. [pristupljeno 16.04.2024.];10(16):5124-5132. doi: 10.12998/wjcc.v10.i16.5124

M. Cigrovski Berković, M. Ulamec, S. Marinović, I. Balen i A. Mrzljak, "Malignant insulinoma: Can we predict the long-term outcomes?", World Journal of Clinical Cases, vol. 10, br. 16, str. 5124-5132, 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:074203. [Citirano: 16.04.2024.]

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Podaci o radu
Naslov (engleski)Malignant insulinoma: Can we predict the long-term outcomes?
AutorMaja Cigrovski Berković
AutorMonika Ulamec
AutorSonja Marinović
AutorIvan Balen
AutorAnna Mrzljak
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Insulinomas are the most frequent type of functional pancreatic neuroendocrine tumors with a variety of neuroglycopenic and autonomic symptoms and well-defined diagnostic criteria; however, prediction of their clinical behavior and early differentiation between benign and malignant lesions remain a challenge. The comparative studies between benign and malignant cases are limited, suggesting that short clinical history, early hypoglycemia during fasting, high proinsulin, insulin, and C-peptide concentrations raise suspicion of malignancy. Indeed, malignant tumors are larger with higher mitotic count and Ki-67 proliferative activity, but there are no accurate histological criteria to distinguish benign from malignant forms. Several signaling pathways have been suggested to affect the pathophysiology and behavior of insulinomas; however, our knowledge is limited, urging a further understanding of molecular genetics. Therefore, there is a need for the identification of reliable markers of metastatic disease that could also serve as therapeutic targets in patients with malignant insulinoma. This opinion review reflects on current gaps in diagnostic and clinical aspects related to the malignant behavior of insulinoma.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaWorld Journal of Clinical Cases
Brojčani podacivol. 10, br. 16, str. 5124-5132
p-ISSN2307-8960
DOIhttps://doi.org/10.12998/wjcc.v10.i16.5124
URN:NBNurn:nbn:hr:105:074203
Datum objave publikacije2022
URL dokumentahttps://www.wjgnet.com/2307-8960/full/v10/i16/5124.htm
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2023-04-18 12:01:55