LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging

Znanstveni rad - Pregledni rad

• Autor: Dajana Krsnik
• Autor: Tihana Marić
• Autor: Floriana Bulić-Jakuš
• Autor: Nino Sinčić
• Autor: Ana Katušić Bojanac
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA MEDICINSKU BIOLOGIJU)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Temeljne medicinske znanosti

Sažetak (engleski)

Male reproductive development starts early in the embryogenesis with somatic and germ cell differentiation in the testis. The LIN28 family of RNA-binding proteins promoting pluripotency has two members—LIN28A and LIN28B. Their function in the testis has been investigated but many questions about their exact role based on the expression patterns remain unclear. LIN28 expression is detected in the gonocytes and the migrating, mitotically active germ cells of the fetal testis. Postnatal expression of LIN28 A and B showed differential expression, with LIN28A expressed in the undifferentiated spermatogonia and LIN28B in the elongating spermatids and Leydig cells. LIN28 interferes with many signaling pathways, leading to cell proliferation, and it is involved in important testicular physiological processes, such as cell renewal, maturation, fertility, and aging. In addition, aberrant LIN28 expression is associated with testicular cancer and testicular disorders, such as hypogonadotropic hypogonadism and Klinefelter’s syndrome. This comprehensive review encompasses current knowledge of the function of LIN28 paralogs in testis and other tissues and cells because many studies suggest LIN28AB as a promising target for developing novel therapeutic agents.

• Ključne riječi (engleski): Aging / genetics; Fertility / genetics; Humans; Klinefelter Syndrome / metabolism; Male; Spermatogonia / metabolism; Testicular Neoplasms / metabolism; Testis / metabolism
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Pregledni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: International Journal of Molecular Sciences
• Brojčani podaci: vol. 23, br. 13, 7245
• e-ISSN: 1422-0067
• DOI: https://doi.org/10.3390/ijms23137245
• URN:NBN: urn:nbn:hr:105:397288
• Datum objave publikacije: 2022-06-29
• URL dokumenta: https://www.mdpi.com/1422-0067/23/13/7245
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2023-04-19 10:55:20