prikaz prve stranice dokumenta Role of Matrix Metalloproteinases and Their Inhibitors in Locally Invasive Papillary Thyroid Cancer
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Role of Matrix Metalloproteinases and Their Inhibitors in Locally Invasive Papillary Thyroid Cancer
Biomedicines, 10 (2022), 12; 3178. https://doi.org/10.3390/biomedicines10123178
Ivković, Irena; Limani, Zgjim; Jakovčević, Antonia; Huić, Dražen; Prgomet, Drago

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Ivković, I., Limani, Z., Jakovčević, A., Huić, D. i Prgomet, D. (2022). Role of Matrix Metalloproteinases and Their Inhibitors in Locally Invasive Papillary Thyroid Cancer. Biomedicines, 10. (12). doi: 10.3390/biomedicines10123178

Ivković, Irena, et al. "Role of Matrix Metalloproteinases and Their Inhibitors in Locally Invasive Papillary Thyroid Cancer." Biomedicines, vol. 10, br. 12, 2022. https://doi.org/10.3390/biomedicines10123178

Ivković, Irena, Zgjim Limani, Antonia Jakovčević, Dražen Huić i Drago Prgomet. "Role of Matrix Metalloproteinases and Their Inhibitors in Locally Invasive Papillary Thyroid Cancer." Biomedicines 10, br. 12 (2022). https://doi.org/10.3390/biomedicines10123178

Ivković, I., et al. (2022) 'Role of Matrix Metalloproteinases and Their Inhibitors in Locally Invasive Papillary Thyroid Cancer', Biomedicines, 10(12). doi: 10.3390/biomedicines10123178

Ivković I, Limani Z, Jakovčević A, Huić D, Prgomet D. Role of Matrix Metalloproteinases and Their Inhibitors in Locally Invasive Papillary Thyroid Cancer. Biomedicines [Internet]. 08.12.2022. [pristupljeno 15.04.2024.];10(12). doi: 10.3390/biomedicines10123178

I. Ivković, Z. Limani, A. Jakovčević, D. Huić i D. Prgomet, "Role of Matrix Metalloproteinases and Their Inhibitors in Locally Invasive Papillary Thyroid Cancer", Biomedicines, vol. 10, br. 12, Prosinac 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:993098. [Citirano: 15.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:993098
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Podaci o radu
Naslov (engleski)Role of Matrix Metalloproteinases and Their Inhibitors in Locally Invasive Papillary Thyroid Cancer
AutorIrena Ivković
AutorZgjim Limani
AutorAntonia Jakovčević
AutorDražen Huić
AutorDrago Prgomet
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA NUKLEARNU MEDICINU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA OTORINOLARINGOLOGIJU I KIRURGIJU GLAVE I VRATA)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Otorinolaringologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Nuklearna medicina
Sažetak (engleski)
Locally invasive papillary thyroid carcinoma (PTC) protrudes beyond the thyroid capsule and invades local structures. Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) are implicated in local invasion and metastasis in PTC. The aim of our study was to determine expression levels of MMP-1, MMP-2, MMP-9, TIMP-1, and TIMP-2 in tissue specimens of invasive and non-invasive PTC. Our hypothesis was that expression levels of these biomarkers correlate with the development of locally invasive PTC. In our single-center study we retrospectively investigated MMP and TIMP expression levels in 50 samples of thyroid tissue diagnosed as locally invasive papillary carcinoma (study group) and 30 samples of thyroid tissue diagnosed as non-invasive, non-metastatic papillary carcinoma (control group). Tissue specimens were immunohistochemically stained with primary monoclonal antibodies against MMP-1, MMP-2, MMP-9, TIMP-1, and TIMP-2. When correlating expression levels of MMPs and TIMPs in thyroid tissue, statistically significant differences were found for MMP-1 and TIMP-1 expression (p < 0.001; Mann–Whitney U test) with the highest levels of expression in the invasive PTC group. Although expression of MMP-9 and TIMP-2 was higher in invasive PTC, the differences were not statistically significant. Elevated expression of MMP-1 and TIMP-1 in tumor tissue can predict invasiveness for PTC.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedicines
Brojčani podacivol. 10, br. 12, 3178
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines10123178
URN:NBNurn:nbn:hr:105:993098
Datum objave publikacije2022-12-08
URL dokumentahttps://www.mdpi.com/2227-9059/10/12/3178
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-04-27 08:30:11