prikaz prve stranice dokumenta Serotonin Receptor Gene Polymorphisms Are Associated with Cerebrospinal Fluid, Genetic, and Neuropsychological Biomarkers of Alzheimer’s Disease
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Serotonin Receptor Gene Polymorphisms Are Associated with Cerebrospinal Fluid, Genetic, and Neuropsychological Biomarkers of Alzheimer’s Disease
Biomedicines, 10 (2022), 12; 3118. https://doi.org/10.3390/biomedicines10123118
Babić Leko, Mirjana; Nikolac Perković, Matea; Španić, Ena; Švob Štrac, Dubravka; Pleić, Nikolina; Vogrinc, Željka; Gunjača, Ivana; Bežovan, Dora; Nedić Erjavec, Gordana; Klepac, Nataša; Borovečki, Fran; Zemunik, Tatijana; Pivac, Nela; Hof, Patrick R.; Šimić, Goran Više autora...

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Babić Leko, M., Nikolac Perković, M., Španić, E., Švob Štrac, D., Pleić, N., Vogrinc, Ž. ... Šimić, G. (2022). Serotonin Receptor Gene Polymorphisms Are Associated with Cerebrospinal Fluid, Genetic, and Neuropsychological Biomarkers of Alzheimer’s Disease. Biomedicines, 10. (12). doi: 10.3390/biomedicines10123118

Babić Leko, Mirjana, et al. "Serotonin Receptor Gene Polymorphisms Are Associated with Cerebrospinal Fluid, Genetic, and Neuropsychological Biomarkers of Alzheimer’s Disease." Biomedicines, vol. 10, br. 12, 2022. https://doi.org/10.3390/biomedicines10123118

Babić Leko, Mirjana, Matea Nikolac Perković, Ena Španić, Dubravka Švob Štrac, Nikolina Pleić, Željka Vogrinc, Ivana Gunjača, et al. "Serotonin Receptor Gene Polymorphisms Are Associated with Cerebrospinal Fluid, Genetic, and Neuropsychological Biomarkers of Alzheimer’s Disease." Biomedicines 10, br. 12 (2022). https://doi.org/10.3390/biomedicines10123118

Babić Leko, M., et al. (2022) 'Serotonin Receptor Gene Polymorphisms Are Associated with Cerebrospinal Fluid, Genetic, and Neuropsychological Biomarkers of Alzheimer’s Disease', Biomedicines, 10(12). doi: 10.3390/biomedicines10123118

Babić Leko M, Nikolac Perković M, Španić E, Švob Štrac D, Pleić N, Vogrinc Ž, i sur.. Serotonin Receptor Gene Polymorphisms Are Associated with Cerebrospinal Fluid, Genetic, and Neuropsychological Biomarkers of Alzheimer’s Disease. Biomedicines [Internet]. 02.12.2022. [pristupljeno 11.04.2024.];10(12). doi: 10.3390/biomedicines10123118

M. Babić Leko, et al., "Serotonin Receptor Gene Polymorphisms Are Associated with Cerebrospinal Fluid, Genetic, and Neuropsychological Biomarkers of Alzheimer’s Disease", Biomedicines, vol. 10, br. 12, Prosinac 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:453653. [Citirano: 11.04.2024.]

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Naslov (engleski)Serotonin Receptor Gene Polymorphisms Are Associated with Cerebrospinal Fluid, Genetic, and Neuropsychological Biomarkers of Alzheimer’s Disease
AutorMirjana Babić Leko
AutorMatea Nikolac Perković
AutorEna Španić
AutorDubravka Švob Štrac
AutorNikolina Pleić
AutorŽeljka Vogrinc
AutorIvana Gunjača
AutorDora Bežovan
AutorGordana Nedić Erjavec
AutorNataša Klepac
AutorFran Borovečki
AutorTatijana Zemunik
AutorNela Pivac
AutorPatrick R. Hof
AutorGoran Šimić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA NEUROLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Neurologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Sažetak (engleski)
A decrease in serotonergic transmission throughout the brain is among the earliest pathological changes in Alzheimer’s disease (AD). Serotonergic receptors are also affected in AD. Polymorphisms in genes of serotonin (5HT) receptors have been mostly associated with behavioral and psychological symptoms of dementia (BPSD). In this study, we examined if AD patients carrying different genotypes in 5HTR1B rs13212041, 5HTR2A rs6313 (T102C), 5HTR2C rs3813929 (−759C/T), and 5HTR6 rs1805054 (C267T) polymorphisms have a higher risk of faster disease progression (assessed by neuropsychological testing), are more prone to develop AD-related pathology (reflected by levels of cerebrospinal fluid [CSF] AD biomarkers), or have an association with an apolipoprotein E (APOE) haplotype. This study included 115 patients with AD, 53 patients with mild cognitive impairment (MCI), and 2701 healthy controls. AD biomarkers were determined in the CSF of AD and MCI patients using enzyme-linked immunosorbent assays (ELISA), while polymorphisms were determined using either TaqMan SNP Genotyping Assays or Illumina genotyping platforms. We detected a significant decrease in the CSF amyloid β1–42 (Aβ1–42) and an increase in p-tau181/Aβ1–42 ratio in carriers of the T allele in the 5HTR2C rs3813929 (−759C/T) polymorphism. A significantly higher number of APOE ε4 allele carriers was observed among individuals carrying a TT genotype within the 5HTR2A T102C polymorphism, a C allele within the 5HTR1B rs13212041 polymorphism, and a T allele within the 5HTR6 rs1805054 (C267T) polymorphism. Additionally, individuals carrying the C allele within the 5HTR1B rs13212041 polymorphism were significantly more represented among AD patients and had poorer performances on the Rey–Osterrieth test. Carriers of the T allele within the 5HTR6 rs1805054 had poorer performances on the MMSE and ADAS–Cog. As all four analyzed polymorphisms of serotonin receptor genes showed an association with either genetic, CSF, or neuropsychological biomarkers of AD, they deserve further investigation as potential early genetic biomarkers of AD.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedicines
Brojčani podacivol. 10, br. 12, 3118
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines10123118
URN:NBNurn:nbn:hr:105:453653
Datum objave publikacije2022-12-02
ProjektŠifra: IP-2019-04-3584
Naziv (hrvatski): Uloga krvno-moždane barijere, urođene imunosti i oligomerizacije tau proteina u patogenezi Alzheimerove bolesti
Naziv (engleski): Role of blood-brain barrier, innate immunity, and tau protein oligomerization in the pathogenesis of Alzheimer's disease
Kratica: ALZ-BBB-INNATETAU
Voditelj: Goran Šimić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
ProjektŠifra: IP-2014-09-9730
Naziv (hrvatski): Hiperfosforilacija, agregacija i transsinaptički prijenos tau proteina u Alzheimerovoj bolesti: analiza likvora i ispitivanje potencijalnih neuroprotektivnih spojeva
Naziv (engleski): Tau protein hyperphosphorylation, aggregation and trans-synaptic transfer in Alzheimer's disease: cerebrospinal fluid analysis and assessment of potential neuroprotective compounds
Kratica: ALZTAUPROTECT
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
ProjektŠifra: IP-2019-04-2593
Naziv (hrvatski): Reguliranje funkcije štitne i doštitne žlijezde i homeostaze kalcija u krvi
Naziv (engleski): Regulation of thyroid and parathyroid function and blood calcium homeostasis
Kratica: THPTHCAREGULATION
Voditelj: Tatijana Zemunik
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
URL dokumentahttps://www.mdpi.com/2227-9059/10/12/3118
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-05-15 10:42:16