prikaz prve stranice dokumenta Do Semaphorins Play a Role in Development of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease?
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Do Semaphorins Play a Role in Development of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease?
Biomedicines, 10 (2022), 12; 3014. https://doi.org/10.3390/biomedicines10123014
Šamadan, Lara; Papić, Neven; Mijić, Maja; Knežević Štromar, Ivana; Gašparov, Slavko; Vince, Adriana

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Šamadan, L., Papić, N., Mijić, M., Knežević Štromar, I., Gašparov, S. i Vince, A. (2022). Do Semaphorins Play a Role in Development of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease?. Biomedicines, 10. (12). doi: 10.3390/biomedicines10123014

Šamadan, Lara, et al. "Do Semaphorins Play a Role in Development of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease?." Biomedicines, vol. 10, br. 12, 2022. https://doi.org/10.3390/biomedicines10123014

Šamadan, Lara, Neven Papić, Maja Mijić, Ivana Knežević Štromar, Slavko Gašparov i Adriana Vince. "Do Semaphorins Play a Role in Development of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease?." Biomedicines 10, br. 12 (2022). https://doi.org/10.3390/biomedicines10123014

Šamadan, L., et al. (2022) 'Do Semaphorins Play a Role in Development of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease?', Biomedicines, 10(12). doi: 10.3390/biomedicines10123014

Šamadan L, Papić N, Mijić M, Knežević Štromar I, Gašparov S, Vince A. Do Semaphorins Play a Role in Development of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease?. Biomedicines [Internet]. 23.11.2022. [pristupljeno 03.05.2024.];10(12). doi: 10.3390/biomedicines10123014

L. Šamadan, N. Papić, M. Mijić, I. Knežević Štromar, S. Gašparov i A. Vince, "Do Semaphorins Play a Role in Development of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease?", Biomedicines, vol. 10, br. 12, Studeni 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:444120. [Citirano: 03.05.2024.]

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Podaci o radu
Naslov (engleski)Do Semaphorins Play a Role in Development of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease?
AutorLara Šamadan
AutorNeven Papić
AutorMaja Mijić
AutorIvana Knežević Štromar
AutorSlavko Gašparov
AutorAdriana Vince
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INFEKTOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Infektologija
Sažetak (engleski)
Nonalcoholic fatty liver disease (NAFLD) is associated with systemic changes in immune response linked with chronic low-grade inflammation and disease progression. Semaphorins, a large family of biological response modifiers, were recently recognized as one of the key regulators of immune responses, possibly also associated with chronic liver diseases. The aim of this study was to identify semaphorins associated with NAFLD and their relationship with steatosis and fibrosis stages. In this prospective, case-control study, serum semaphorin concentrations (SEMA3A, -3C, -4A, -4D, -5A and -7A) were measured in 95 NAFLD patients and 35 healthy controls. Significantly higher concentrations of SEMA3A, -3C and -4D and lower concentrations of SEAMA5A and -7A were found in NAFLD. While there was no difference according to steatosis grades, SEMA3C and SEMA4D significantly increased and SEMA3A significantly decreased with fibrosis stages and had better accuracy in predicting fibrosis compared to the FIB-4 score. Immunohistochemistry confirmed higher expression of SEMA4D in hepatocytes, endothelial cells and lymphocytes in NAFLD livers. The SEMA5A rs1319222 TT genotype was more frequent in the NAFLD group and was associated with higher liver stiffness measurements. In conclusion, we provide the first evidence of the association of semaphorins with fibrosis in patients with NAFLD.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedicines
Brojčani podacivol. 10, br. 12, 3014
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines10123014
URN:NBNurn:nbn:hr:105:444120
Datum objave publikacije2022-11-23
ProjektŠifra: UIP-2019-04-7194
Naziv (hrvatski): Uloga imunih semaforina u nealkoholnoj masnoj bolesti jetre i sepsi
Naziv (engleski): The role of immune semaphorins in NAFLD and sepsis
Kratica: SepsisFAT
Voditelj: Neven Papić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: UIP
URL dokumentahttps://www.mdpi.com/2227-9059/10/12/3014
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-05-15 10:49:25