COVID-19 and Pulmonary Thrombosis - An Unresolved Clinical Puzzle: A Single-Center Cohort Study

Znanstveni rad - Izvorni znanstveni rad

• Autor: Loris Močibob
• Autor: Frano Šušak
• Autor: Maja Šitum
• Autor: Klaudija Višković
• Autor: Neven Papić
• Autor: Adriana Vince
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA INFEKTOLOGIJU)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Infektologija

Sažetak (engleski)

Pulmonary thrombosis (PT) is a frequent complication of COVID-19. However, the risk factors, predictive scores, and precise diagnostic guidelines on indications for CT pulmonary angiography (CTPA) are still lacking. This study aimed to analyze the clinical and laboratory characteristics associated with PT in patients with COVID-19. We conducted a cohort study of consecutively hospitalized adult patients with COVID-19 who underwent CTPA at the University Hospital for Infectious Diseases in Zagreb, Croatia between 1 April and 31 December 2021. Of 2078 hospitalized patients, 575 (27.6%) underwent CTPA. PT was diagnosed in 178 (30.9%) patients (69.6% males, median age of 61, IQR 50–69 years). The PT group had a higher CRP, LDH, D-dimer, platelets, and CHOD score. PT was more frequent in patients requiring ≥15 L O2/min (25.0% vs. 39.7%). In multivariable analysis, only D-dimer ≥ 1.0 mg/L (OR 1.78, 95%CI 1.12–2.75) and O2 ≥ 15 L (OR 1.89, 95%CI 1.26–2.84) were associated with PT. PT was not associated with in-hospital mortality. In conclusion, our data confirmed a high incidence of PT in hospitalized patients with COVID-19, however, no correlation with traditional risk factors and mortality was found. CTPA should be performed in patients requiring high-flow supplemental oxygen or those with increased D-dimer levels.

• Ključne riječi (engleski): COVID-19; CTPA; D-dimer; pulmonary angiography; pulmonary thrombosis; venous thromboembolism
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Journal of Clinical Medicine
• Brojčani podaci: vol. 11, br. 23, 7049
• e-ISSN: 2077-0383
• DOI: https://doi.org/10.3390/jcm11237049
• URN:NBN: urn:nbn:hr:105:241408
• Datum objave publikacije: 2022-11-29
• Projekt: Šifra: UIP-2019-04-7194; Naziv (hrvatski): Uloga imunih semaforina u nealkoholnoj masnoj bolesti jetre i sepsi; Naziv (engleski): The role of immune semaphorins in NAFLD and sepsis; Kratica: SepsisFAT; Voditelj: Neven Papić; Pravna nadležnost: Hrvatska; Financijer: HRZZ; Linija financiranja: UIP
• URL dokumenta: https://www.mdpi.com/2077-0383/11/23/7049
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2023-05-17 14:06:37