prikaz prve stranice dokumenta Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation
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Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation
Biomedicines, 10 (2022), 11; 2696. https://doi.org/10.3390/biomedicines10112696
Sikirić, Predrag; Udovičić, Mario; Barišić, Ivan; Balenović, Diana; Živanović Posilović, Gordana; Strinić, Dean; Uzun, Sandra; Sikirić, Sunčana; Krezić, Ivan; Žižek, Helena; Yago, Haidi; Gojković, Slaven; Smoday, Ivan Maria; Kalogjera, Luka; Vraneš, Hrvoje; Sola, Marija; Štrbe, Sanja; Koprivanac, Antun; Premužić Meštrović, Ivica; Meštrović, Tomislav; Pavić, Predrag; Škrtić, Anita; Boban Blagaić, Alenka; Lovrić Benčić, Martina; Seiwerth, Sven Više autora...

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Sikirić, P., Udovičić, M., Barišić, I., Balenović, D., Živanović Posilović, G., Strinić, D. ... Seiwerth, S. (2022). Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation. Biomedicines, 10. (11). doi: 10.3390/biomedicines10112696

Sikirić, Predrag, et al. "Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation." Biomedicines, vol. 10, br. 11, 2022. https://doi.org/10.3390/biomedicines10112696

Sikirić, Predrag, Mario Udovičić, Ivan Barišić, Diana Balenović, Gordana Živanović Posilović, Dean Strinić, Sandra Uzun, et al. "Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation." Biomedicines 10, br. 11 (2022). https://doi.org/10.3390/biomedicines10112696

Sikirić, P., et al. (2022) 'Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation', Biomedicines, 10(11). doi: 10.3390/biomedicines10112696

Sikirić P, Udovičić M, Barišić I, Balenović D, Živanović Posilović G, Strinić D, i sur.. Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation. Biomedicines [Internet]. 25.10.2022. [pristupljeno 11.04.2024.];10(11). doi: 10.3390/biomedicines10112696

P. Sikirić, et al., "Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation", Biomedicines, vol. 10, br. 11, Listopad 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:861048. [Citirano: 11.04.2024.]

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Naslov (engleski)Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation
AutorPredrag Sikirić
AutorMario Udovičić
AutorIvan Barišić
AutorDiana Balenović
AutorGordana Živanović Posilović
AutorDean Strinić
AutorSandra Uzun
AutorSunčana Sikirić
AutorIvan Krezić
AutorHelena Žižek
AutorHaidi Yago
AutorSlaven Gojković
AutorIvan Maria Smoday
AutorLuka Kalogjera
AutorHrvoje Vraneš
AutorMarija Sola
AutorSanja Štrbe
MBZ: 319335
AutorAntun Koprivanac
AutorIvica Premužić Meštrović
AutorTomislav Meštrović
AutorPredrag Pavić
AutorAnita Škrtić
AutorAlenka Boban Blagaić
AutorMartina Lovrić Benčić
AutorSven Seiwerth
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA KIRURGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PATOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Sažetak (engleski)
In heart disturbances, stable gastric pentadecapeptide BPC 157 especial therapy effects combine the therapy of myocardial infarction, heart failure, pulmonary hypertension arrhythmias, and thrombosis prevention and reversal. The shared therapy effect occurred as part of its even larger cytoprotection (cardioprotection) therapy effect (direct epithelial cell protection; direct endothelium cell protection) that BPC 157 exerts as a novel cytoprotection mediator, which is native and stable in human gastric juice, as well as easily applicable. Accordingly, there is interaction with many molecular pathways, combining maintained endothelium function and maintained thrombocytes function, which counteracted thrombocytopenia in rats that underwent major vessel occlusion and deep vein thrombosis and counteracted thrombosis in all vascular studies; the coagulation pathways were not affected. These appeared as having modulatory effects on NO-system (NO-release, NOS-inhibition, NO-over-stimulation all affected), controlling vasomotor tone and the activation of the Src-Caveolin-1-eNOS pathway and modulatory effects on the prostaglandins system (BPC 157 counteracted NSAIDs toxicity, counteracted bleeding, thrombocytopenia, and in particular, leaky gut syndrome). As an essential novelty noted in the vascular studies, there was the activation of the collateral pathways. This might be the upgrading of the minor vessel to take over the function of the disabled major vessel, competing with and counteracting the Virchow triad circumstances devastatingly present, making possible the recruitment of collateral blood vessels, compensating vessel occlusion and reestablishing the blood flow or bypassing the occluded or ruptured vessel. As a part of the counteraction of the severe vessel and multiorgan failure syndrome, counteracted were the brain, lung, liver, kidney, gastrointestinal lesions, and in particular, the counteraction of the heart arrhythmias and infarction.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedicines
Brojčani podacivol. 10, br. 11, 2696
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines10112696
URN:NBNurn:nbn:hr:105:861048
Datum objave publikacije2022-10-25
URL dokumentahttps://www.mdpi.com/2227-9059/10/11/2696
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-07-13 07:58:48