White coat hypertension is another clinical characteristic of patients with inflammatory bowel disease: A cross-sectional study

Znanstveni rad - Izvorni znanstveni rad

• Autor: Vedran Premužić
• Autor: Radovan Prijić
• Autor: Mislav Jelaković
• Autor: Željko Krznarić; MBZ: 75865
• Autor: Silvija Čuković-Čavka
• Autor: Bojan Jelaković
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA INTERNU MEDICINU)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Interna medicina

Sažetak (engleski)

In this cross-sectional study, our aim was to analyze association of ambulatory blood pressure monitoring (ABPM) values with pulse wave velocity (PWV) in inflammatory bowel disease (IBD) patients as well as the prevalence and characteristics of white coat hypertension (WCH) in this group of patients with chronic inflammation and high prevalence of anxiety. We enrolled 120 consecutive IBD patients (77 Crohn´s disease; 43 ulcerative colitis) who were not treated with antihypertensive drugs without cardiovascular, cerebrovascular and renal morbidity. Office blood pressure, ABPM, and PWV were measured with Omrom M6, SpaceLab 90207, and Arteriograph, respectively. The prevalence of true normotension, sustained hypertension and WCH was analyzed in IBD patients. WCH was found in 27.5% patients. IBD-WCH patients had significantly lower prevalence of traditional risk factors than general WCH subjects. PWV and augmentation index (AIx) values were higher in WCH than in true normotensive patients. When adjusted for age and duration of IBD, only PWV was a positive predictor of WCH, and patients with higher PWV and longer disease duration had OR´s for WCH of 0.69 and 2.50, respectively. IBD patients had significantly higher prevalence of WCH and higher PWV values than healthy control patients. WCH is highly prevalent in IBD patients but IBD-WCH patients have lower frequency of traditional cardiovascular risk factors than general WCH population. Our results suggest that WCH could be considered as another clinical characteristic of IBD which is associated with increased arterial stiffness and those patients should be monitored more closely.

• Ključne riječi (engleski): Blood Pressure / physiology; Blood Pressure Monitoring, Ambulatory; Cross-Sectional Studies; Humans; Hypertension / drug therapy; Inflammatory Bowel Diseases / complications; Inflammatory Bowel Diseases / epidemiology; Pulse Wave Analysis; White Coat Hypertension / diagnosis; White Coat Hypertension / epidemiology
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Medicine
• Brojčani podaci: vol. 101, br. 44, e29722
• e-ISSN: 1536-5964
• DOI: https://doi.org/10.1097/MD.0000000000029722
• URN:NBN: urn:nbn:hr:105:143752
• Datum objave publikacije: 2022-11-04
• URL dokumenta: https://journals.lww.com/10.1097/MD.0000000000029722
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2023-07-14 08:49:18