prikaz prve stranice dokumenta Cholesterol Content of Very-Low-Density Lipoproteins Is Associated with 1-Year Mortality in Acute Heart Failure Patients
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Cholesterol Content of Very-Low-Density Lipoproteins Is Associated with 1-Year Mortality in Acute Heart Failure Patients
Biomolecules, 12 (2022), 10; 1542. https://doi.org/10.3390/biom12101542
Degoricija, Vesna; Klobučar, Iva; Potočnjak, Ines; Dokoza Terešak, Sanda; Vidović, Luka; Pregartner, Gudrun; Berghold, Andrea; Habisch, Hansjörg; Madl, Tobias; Frank, Saša

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Degoricija, V., Klobučar, I., Potočnjak, I., Dokoza Terešak, S., Vidović, L., Pregartner, G. ... Frank, S. (2022). Cholesterol Content of Very-Low-Density Lipoproteins Is Associated with 1-Year Mortality in Acute Heart Failure Patients. Biomolecules, 12. (10). doi: 10.3390/biom12101542

Degoricija, Vesna, et al. "Cholesterol Content of Very-Low-Density Lipoproteins Is Associated with 1-Year Mortality in Acute Heart Failure Patients." Biomolecules, vol. 12, br. 10, 2022. https://doi.org/10.3390/biom12101542

Degoricija, Vesna, Iva Klobučar, Ines Potočnjak, Sanda Dokoza Terešak, Luka Vidović, Gudrun Pregartner, Andrea Berghold, Hansjörg Habisch, Tobias Madl i Saša Frank. "Cholesterol Content of Very-Low-Density Lipoproteins Is Associated with 1-Year Mortality in Acute Heart Failure Patients." Biomolecules 12, br. 10 (2022). https://doi.org/10.3390/biom12101542

Degoricija, V., et al. (2022) 'Cholesterol Content of Very-Low-Density Lipoproteins Is Associated with 1-Year Mortality in Acute Heart Failure Patients', Biomolecules, 12(10). doi: 10.3390/biom12101542

Degoricija V, Klobučar I, Potočnjak I, Dokoza Terešak S, Vidović L, Pregartner G, i sur.. Cholesterol Content of Very-Low-Density Lipoproteins Is Associated with 1-Year Mortality in Acute Heart Failure Patients. Biomolecules [Internet]. 21.10.2022. [pristupljeno 13.04.2024.];12(10). doi: 10.3390/biom12101542

V. Degoricija, et al., "Cholesterol Content of Very-Low-Density Lipoproteins Is Associated with 1-Year Mortality in Acute Heart Failure Patients", Biomolecules, vol. 12, br. 10, Listopad 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:940839. [Citirano: 13.04.2024.]

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Naslov (engleski)Cholesterol Content of Very-Low-Density Lipoproteins Is Associated with 1-Year Mortality in Acute Heart Failure Patients
AutorVesna Degoricija
AutorIva Klobučar
AutorInes Potočnjak
AutorSanda Dokoza Terešak
AutorLuka Vidović
AutorGudrun Pregartner
AutorAndrea Berghold
AutorHansjörg Habisch
AutorTobias Madl
AutorSaša Frank
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Considering the relationship between the extent of metabolic derangement and the disease severity in heart failure, we hypothesized that the lipid content of very-low-density lipoprotein (VLDL) may have prognostic value for 1 year mortality in acute heart failure (AHF). Baseline serum levels of VLDL cholesterol (VLDL-C), VLDL triglycerides (VLDL-TG), VLDL phospholipids (VLDL-PL), and VLDL apolipoprotein B (VLDL-apoB) were measured using NMR spectroscopy. We calculated the ratios of the respective VLDL lipids and VLDL apoB (VLDL-C/VLDL-apoB, VLDL-TG/VLDL-apoB, and VLDL-PL/VLDL-apoB), as estimators of the cholesterol, triglyceride, and phospholipid content of VLDL particles and tested their association with mortality. Out of 315 AHF patients, 118 (37.5%) patients died within 1 year after hospitalization for AHF. Univariable Cox regression analyses revealed a significant inverse association of VLDL-C/VLDL-apoB (hazard ratio (HR) 0.43, 95% confidence interval (CI) 0.29–0.64, p < 0.001), VLDL-TG/VLDL-apoB (HR 0.79, 95% CI 0.71–0.88, p < 0.001), and VLDL-PL/VLDL-apoB (HR 0.37, 95% CI 0.25–0.56, p < 0.001) with 1 year mortality. Of the tested parameters, only VLDL-C/VLDL-apoB remained significant after adjustment for age and sex, as well as other clinical and laboratory parameters that showed a significant association with 1 year mortality in the univariable analyses. We conclude that cholesterol content of circulating VLDL (VLDL-C/VLDL-apoB) might be of prognostic value in AHF.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomolecules
Brojčani podacivol. 12, br. 10, 1542
e-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom12101542
URN:NBNurn:nbn:hr:105:940839
Datum objave publikacije2022-10-21
URL dokumentahttps://www.mdpi.com/2218-273X/12/10/1542
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-08-21 07:52:01