prikaz prve stranice dokumenta Lipidomics Revealed Plasma Phospholipid Profile Differences between Deceased and Recovered COVID-19 Patients
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Lipidomics Revealed Plasma Phospholipid Profile Differences between Deceased and Recovered COVID-19 Patients
Biomolecules, 12 (2022), 10; 1488. https://doi.org/10.3390/biom12101488
Žarković, Neven; Orehovec, Biserka; Baršić, Bruno; Tarle, Marko; Kmet, Marta; Lukšić, Ivica; Tatzber, Franz; Wonisch, Willibald; Skrzydlewska, Elżbieta; Łuczaj, Wojciech

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Žarković, N., Orehovec, B., Baršić, B., Tarle, M., Kmet, M., Lukšić, I. ... Łuczaj, W. (2022). Lipidomics Revealed Plasma Phospholipid Profile Differences between Deceased and Recovered COVID-19 Patients. Biomolecules, 12. (10). doi: 10.3390/biom12101488

Žarković, Neven, et al. "Lipidomics Revealed Plasma Phospholipid Profile Differences between Deceased and Recovered COVID-19 Patients." Biomolecules, vol. 12, br. 10, 2022. https://doi.org/10.3390/biom12101488

Žarković, Neven, Biserka Orehovec, Bruno Baršić, Marko Tarle, Marta Kmet, Ivica Lukšić, Franz Tatzber, Willibald Wonisch, Elżbieta Skrzydlewska i Wojciech Łuczaj. "Lipidomics Revealed Plasma Phospholipid Profile Differences between Deceased and Recovered COVID-19 Patients." Biomolecules 12, br. 10 (2022). https://doi.org/10.3390/biom12101488

Žarković, N., et al. (2022) 'Lipidomics Revealed Plasma Phospholipid Profile Differences between Deceased and Recovered COVID-19 Patients', Biomolecules, 12(10). doi: 10.3390/biom12101488

Žarković N, Orehovec B, Baršić B, Tarle M, Kmet M, Lukšić I, i sur.. Lipidomics Revealed Plasma Phospholipid Profile Differences between Deceased and Recovered COVID-19 Patients. Biomolecules [Internet]. 15.10.2022. [pristupljeno 14.04.2024.];12(10). doi: 10.3390/biom12101488

N. Žarković, et al., "Lipidomics Revealed Plasma Phospholipid Profile Differences between Deceased and Recovered COVID-19 Patients", Biomolecules, vol. 12, br. 10, Listopad 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:350109. [Citirano: 14.04.2024.]

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Podaci o radu
Naslov (engleski)Lipidomics Revealed Plasma Phospholipid Profile Differences between Deceased and Recovered COVID-19 Patients
AutorNeven Žarković
AutorBiserka Orehovec
AutorBruno Baršić
AutorMarko Tarle
AutorMarta Kmet
AutorIvica Lukšić
AutorFranz Tatzber
AutorWillibald Wonisch
AutorElżbieta Skrzydlewska
AutorWojciech Łuczaj
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MAKSILOFACIJALNU KIRURGIJU SA STOMATOLOGIJOM)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Sažetak (engleski)
Thorough understanding of metabolic changes, including lipidome alteration, associated with the development of COVID-19 appears to be crucial, as new types of coronaviruses are still reported. In this study, we analyzed the differences in the plasma phospholipid profiles of the deceased COVID-19 patients, those who recovered and healthy people. Due to identified abnormalities in plasma phospholipid profiles, deceased patients were further divided into two subgroups (D1 and D2). Increased levels of phosphatidylethanolamines (PE), phosphatidylcholines (PC) and phosphatidylserines (PS) were found in the plasma of recovered patients and the majority of deceased patients (first subgroup D1) compared to the control group. However, abundances of all relevant PE, PC and PS species decreased dramatically in the plasma of the second subgroup (D2) of five deceased patients. These patients also had significantly decreased plasma COX-2 activity when compared to the control, in contrast to unchanged and increased COX-2 activity in the plasma of the other deceased patients and recovered patients, respectively. Moreover, these five deceased patients were characterized by abnormally low CRP levels and tremendous increase in LDH levels, which may be the result of other pathophysiological disorders, including disorders of the immune system, liver damage and haemolytic anemia. In addition, an observed trend to decrease the autoantibodies against oxidative modifications of low-density lipoprotein (oLAb) titer in all, especially in deceased patients, indicate systemic oxidative stress and altered immune system that may have prognostic value in COVID-19.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomolecules
Brojčani podacivol. 12, br. 10, 1488
e-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom12101488
URN:NBNurn:nbn:hr:105:350109
Datum objave publikacije2022-10-15
URL dokumentahttps://www.mdpi.com/2218-273X/12/10/1488
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-08-21 08:10:11