prikaz prve stranice dokumenta Serum S100A12 levels in children with childhood-onset systemic lupus erythematosus, systemic juvenile arthritis, and systemic undefined recurrent fevers
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Serum S100A12 levels in children with childhood-onset systemic lupus erythematosus, systemic juvenile arthritis, and systemic undefined recurrent fevers
Zeitschrift für Rheumatologie, 82 (2021), S1; 74-79. https://doi.org/10.1007/s00393-021-01142-9
Bobek, Dubravka; Šestan, Mario; Mijačika, Luciana; Kovačić, Nataša; Lukić, Ivan Krešimir; Grčević, Danka; Jelušić, Marija

Citirajte ovaj rad

Bobek, D., Šestan, M., Mijačika, L., Kovačić, N., Lukić, I. K., Grčević, D. i Jelušić, M. (2021). Serum S100A12 levels in children with childhood-onset systemic lupus erythematosus, systemic juvenile arthritis, and systemic undefined recurrent fevers. Zeitschrift für Rheumatologie, 82. (S1), 74-79. doi: 10.1007/s00393-021-01142-9

Bobek, Dubravka, et al. "Serum S100A12 levels in children with childhood-onset systemic lupus erythematosus, systemic juvenile arthritis, and systemic undefined recurrent fevers." Zeitschrift für Rheumatologie, vol. 82, br. S1, 2021, str. 74-79. https://doi.org/10.1007/s00393-021-01142-9

Bobek, Dubravka, Mario Šestan, Luciana Mijačika, Nataša Kovačić, Ivan Krešimir Lukić, Danka Grčević i Marija Jelušić. "Serum S100A12 levels in children with childhood-onset systemic lupus erythematosus, systemic juvenile arthritis, and systemic undefined recurrent fevers." Zeitschrift für Rheumatologie 82, br. S1 (2021): 74-79. https://doi.org/10.1007/s00393-021-01142-9

Bobek, D., et al. (2021) 'Serum S100A12 levels in children with childhood-onset systemic lupus erythematosus, systemic juvenile arthritis, and systemic undefined recurrent fevers', Zeitschrift für Rheumatologie, 82(S1), str. 74-79. doi: 10.1007/s00393-021-01142-9

Bobek D, Šestan M, Mijačika L, Kovačić N, Lukić IK, Grčević D, i sur.. Serum S100A12 levels in children with childhood-onset systemic lupus erythematosus, systemic juvenile arthritis, and systemic undefined recurrent fevers. Zeitschrift für Rheumatologie [Internet]. 23.12.2021. [pristupljeno 13.04.2024.];82(S1):74-79. doi: 10.1007/s00393-021-01142-9

D. Bobek, et al., "Serum S100A12 levels in children with childhood-onset systemic lupus erythematosus, systemic juvenile arthritis, and systemic undefined recurrent fevers", Zeitschrift für Rheumatologie, vol. 82, br. S1, str. 74-79, Prosinac 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:138598. [Citirano: 13.04.2024.]

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Podaci o radu
Naslov (engleski)Serum S100A12 levels in children with childhood-onset systemic lupus erythematosus, systemic juvenile arthritis, and systemic undefined recurrent fevers
AutorDubravka Bobek
AutorMario Šestan
AutorLuciana Mijačika
AutorNataša Kovačić
AutorIvan Krešimir Lukić
AutorDanka Grčević
AutorMarija Jelušić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ANATOMIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA FIZIOLOGIJU I IMUNOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PSIHIJATRIJU I PSIHOLOŠKU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Fiziologija čovjeka
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Sažetak (engleski)
Background: We compared serum levels of S100A12, a proinflammatory protein predominantly secreted by neutrophils, in children with newly diagnosed childhood-onset systemic lupus erythematosus (cSLE), systemic juvenile arthritis (sJIA), and systemic undefined recurrent fevers (SURFS) to examine its role as a diagnostic and discriminative marker of inflammation and to indirectly point out the importance of neutrophils and innate immunity in the pathogenesis of these diseases. Materials and methods: In a cross-sectional study, the serum levels of S100A12 protein of 68 children (19 with cSLE, 18 with sJIA, 7 with SURFS, and 24 controls) were determined by enzyme-linked immunosorbent assay and compared between groups and with clinical and laboratory findings. Results: The median serum S100A12 levels were 469 ng/mL in the cSLE group, 6103 ng/mL in the sJIA group, 480 ng/mL in the SURFS group, and 44 ng/mL in the control group. Children with cSLE, sJIA, and SURFS had significantly higher serum S100A12 levels compared to the control group (p < 0.0001). sJIA patients had the highest levels of S100A12 in comparison to other patients (p < 0.0001), while there was no significant difference between children with cSLE and SURFS. Conclusion: Elevated serum SA100A12 levels in children with cSLE, sJIA, and SURFS may indicate intense neutrophil activation, which may play an important role in innate immunity in chronic inflammation in these diseases. Serum S100A12 levels could be used as a diagnostic marker of inflammation and be suitable for distinguishing sJIA and other disorders.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeRukopis poslan na recenzijski postupak (preprint)
Naslov časopisaZeitschrift für Rheumatologie
Brojčani podacivol. 82, br. S1, str. 74-79
p-ISSN0340-1855
e-ISSN1435-1250
DOIhttps://doi.org/10.1007/s00393-021-01142-9
URN:NBNurn:nbn:hr:105:138598
Datum objave publikacije2021-12-23
URL dokumentahttps://link.springer.com/10.1007/s00393-021-01142-9
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Datum isteka embarga: 2024-02-01
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-08-30 11:06:57