Point Shear Wave Elastography by ElastPQ for Fibrosis Screening in Patients with NAFLD: A Prospective, Multicenter Comparison to Vibration-Controlled Elastography

Znanstveni rad - Izvorni znanstveni rad

• Autor: David JM Bauer
• Autor: Vladimir Matić; MBZ: 142564
• Autor: Ruxandra Mare
• Autor: Laura Maiocchi
• Autor: David Chromy
• Autor: Theresa Müllner-Bucsics
• Autor: Mattias Mandorfer
• Autor: Sandra Mustapić
• Autor: Ioan Sporea
• Autor: Giovanna Ferraioli
• Autor: Ivica Grgurević
• Autor: Thomas Reiberger
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA INTERNU MEDICINU)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Interna medicina

Sažetak (engleski)

Background: Since nonalcoholic fatty liver disease (NAFLD) has become the leading cause of liver disease in the Western world, clinicians need reliable noninvasive tools for the identification of NAFLD-associated fibrosis. Limited evidence on the performance of the novel shear wave elastography technique Elast-PQ (EPQ) in NAFLD is available.

Method: In this prospective, European multinational study we assessed the diagnostic accuracy of EPQ using vibration-controlled transient elastography (VCTE) as a reference standard.

Results: Among 353 NAFLD patients, 332 (94.1%) fulfilled reliability criteria of VCTE and EPQ (defined by IQR/median ≤0.3; 41.3% female, mean age: 59 [IQR: 16.5], mean BMI: 29.0 (7.1)). 4/353 (1.1%) and 17/353 (4.8%) had unreliable VCTE and EPQ measurements, respectively. VCTE-based NAFLD fibrosis stages were F0/F1: 222(66.9%), F2: 41 (12.3%), F3: 30 (9.1%), F4: 39 (11.7%). We found a strong correlation (Pearson R=0.87; p<0.0001) and concordance (Lin's concordance correlation coefficient =0.792) of EPQ with VCTE. EPQ was able to identify NAFLD-fibrosis risk with the following EPQ cutoffs: ≥6.5 kPa for significant fibrosis (≥F2) (≥1.47 m/s; sensitivity: 78%; specificity: 95%; AUROC: 0.94), ≥6.9 kPa for advanced fibrosis (≥F3) (≥1.52 m/s; sens.: 88%, spec.: 89%; AUROC: 0.949), and ≥10.4 kPa for cirrhosis (F4) (≥1.86 m/s; sens.: 87%; spec.: 94%; AUROC: 0.949).

Conclusion: The point shear wave elastography technique EPQ shows excellent correlation to and concordance with VCTE. EPQ can reliably exclude NAFLD fibrosis <6.0 kPa (<1.41 m/s) and indicate a high risk of advanced fibrosis ≥10.4 kPa (≥1.86 m/s).

• Ključne riječi (engleski): Elasticity Imaging Techniques / methods; Female; Fibrosis; Humans; Liver / diagnostic imaging; Liver Cirrhosis / diagnostic imaging; Male; Middle Aged; Non-alcoholic Fatty Liver Disease / diagnostic imaging; Prospective Studies; Reproducibility of Results; Vibration
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Ultraschall in der Medizin - European Journal of Ultrasound
• Brojčani podaci: vol. 44, br. 02, str. 169-178
• p-ISSN: 0172-4614
• e-ISSN: 1438-8782
• DOI: https://doi.org/10.1055/a-1724-7289
• URN:NBN: urn:nbn:hr:105:708121
• Datum objave publikacije: 2022-02-28
• URL dokumenta: http://www.thieme-connect.de/DOI/DOI?10.1055/a-1724-7289
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2023-08-31 08:22:31