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The Oxygen and Glucose Deprivation of Immature Cells of the Nervous System Exerts Distinct Effects on Mitochondria, Mitophagy, and Autophagy, Depending on the Cells’ Differentiation Stage
Brain Sciences, 13 (2023), 6; 910. https://doi.org/10.3390/brainsci13060910
Jagečić, Denis; Petrović, Dražen Juraj; Šimunić, Iva; Isaković, Jasmina; Mitrečić, Dinko

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Jagečić, D., Petrović, D. J., Šimunić, I., Isaković, J. i Mitrečić, D. (2023). The Oxygen and Glucose Deprivation of Immature Cells of the Nervous System Exerts Distinct Effects on Mitochondria, Mitophagy, and Autophagy, Depending on the Cells’ Differentiation Stage. Brain Sciences, 13. (6). doi: 10.3390/brainsci13060910

Jagečić, Denis, et al. "The Oxygen and Glucose Deprivation of Immature Cells of the Nervous System Exerts Distinct Effects on Mitochondria, Mitophagy, and Autophagy, Depending on the Cells’ Differentiation Stage." Brain Sciences, vol. 13, br. 6, 2023. https://doi.org/10.3390/brainsci13060910

Jagečić, Denis, Dražen Juraj Petrović, Iva Šimunić, Jasmina Isaković i Dinko Mitrečić. "The Oxygen and Glucose Deprivation of Immature Cells of the Nervous System Exerts Distinct Effects on Mitochondria, Mitophagy, and Autophagy, Depending on the Cells’ Differentiation Stage." Brain Sciences 13, br. 6 (2023). https://doi.org/10.3390/brainsci13060910

Jagečić, D., et al. (2023) 'The Oxygen and Glucose Deprivation of Immature Cells of the Nervous System Exerts Distinct Effects on Mitochondria, Mitophagy, and Autophagy, Depending on the Cells’ Differentiation Stage', Brain Sciences, 13(6). doi: 10.3390/brainsci13060910

Jagečić D, Petrović DJ, Šimunić I, Isaković J, Mitrečić D. The Oxygen and Glucose Deprivation of Immature Cells of the Nervous System Exerts Distinct Effects on Mitochondria, Mitophagy, and Autophagy, Depending on the Cells’ Differentiation Stage. Brain Sciences [Internet]. 04.06.2023. [pristupljeno 26.12.2024.];13(6). doi: 10.3390/brainsci13060910

D. Jagečić, D. J. Petrović, I. Šimunić, J. Isaković i D. Mitrečić, "The Oxygen and Glucose Deprivation of Immature Cells of the Nervous System Exerts Distinct Effects on Mitochondria, Mitophagy, and Autophagy, Depending on the Cells’ Differentiation Stage", Brain Sciences, vol. 13, br. 6, Lipanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:578498. [Citirano: 26.12.2024.]

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Naslov (engleski)The Oxygen and Glucose Deprivation of Immature Cells of the Nervous System Exerts Distinct Effects on Mitochondria, Mitophagy, and Autophagy, Depending on the Cells’ Differentiation Stage
AutorDenis Jagečić
AutorDražen Juraj Petrović
AutorIva Šimunić
AutorJasmina Isaković
AutorDinko Mitrečić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA HISTOLOGIJU I EMBRIOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Citologija, histologija i embriologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Sažetak (engleski)
Perinatal brain damage, one of the most common causes of lifelong impairment, is predominantly caused by a lack of oxygen and glucose during early development. These conditions, in turn, affect cells of the nervous tissue through various stages of their maturation. To quantify the influence of these factors on cell differentiation and mitochondrial parameters, we exposed neural cell precursors to oxygen and glucose deprivation (OGD) during three stages of their differentiation: day 1, day 7, and day 14 (D1, D7, and D14, respectively). The obtained results show that OGD slows down cellular differentiation and causes cell death. Regardless of the level of cell maturity, the overall area of the mitochondria, their length, and the branching of their filaments decreased uniformly when exposed to OGD-related stress. Moreover, the cells in all stages of differentiation exhibited an increase in ROS production, hyperpolarization of the mitochondrial membrane, and autophagy. Interestingly, day 7 was the only stage in which a significant increase in mitochondrial fission, along with measurable instances of mitophagy, were detected. Taken together, the results of this study suggest that, apart from common reactions to a sudden lack of oxygen and glucose, cells in specific stages of neural differentiation can also exhibit increased preferences for mitochondrial fission and mitophagy. Such findings could play a role in guiding the future development of novel therapeutic approaches targeting perinatal brain damage during specific stages of nervous system development.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBrain Sciences
Brojčani podacivol. 13, br. 6, 910
e-ISSN2076-3425
DOIhttps://doi.org/10.3390/brainsci13060910
URN:NBNurn:nbn:hr:105:578498
Datum objave publikacije2023-06-04
ProjektŠifra: IP-2016-06-9451
Naziv (hrvatski): Matične stanice usne šupljine čovjeka za liječenje ishemijske bolesti mozga
Kratica: ORASTEM
Voditelj: Dinko Mitrečić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
URL dokumentahttps://www.mdpi.com/2076-3425/13/6/910
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-09-25 08:01:17