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Analysis of the Gut Microbiome and Dietary Habits in Metastatic Melanoma Patients with a Complete and Sustained Response to Immunotherapy
Cancers, 15 (2023), 11; 3052. https://doi.org/10.3390/cancers15113052
Golčić, Marin; Simetić, Luka; Herceg, Davorin; Blažičević, Krešimir; Kenđel Jovanović, Gordana; Dražić, Ivan; Belančić, Andrej; Skočibušić, Nataša; Palčevski, Dora; Rubinić, Igor; Vlahović-Palčevski, Vera; Majnarić, Tea; Dobrila-Dintinjana, Renata; Pleština, Stjepko

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Golčić, M., Simetić, L., Herceg, D., Blažičević, K., Kenđel Jovanović, G., Dražić, I. ... Pleština, S. (2023). Analysis of the Gut Microbiome and Dietary Habits in Metastatic Melanoma Patients with a Complete and Sustained Response to Immunotherapy. Cancers, 15. (11). doi: 10.3390/cancers15113052

Golčić, Marin, et al. "Analysis of the Gut Microbiome and Dietary Habits in Metastatic Melanoma Patients with a Complete and Sustained Response to Immunotherapy." Cancers, vol. 15, br. 11, 2023. https://doi.org/10.3390/cancers15113052

Golčić, Marin, Luka Simetić, Davorin Herceg, Krešimir Blažičević, Gordana Kenđel Jovanović, Ivan Dražić, Andrej Belančić, et al. "Analysis of the Gut Microbiome and Dietary Habits in Metastatic Melanoma Patients with a Complete and Sustained Response to Immunotherapy." Cancers 15, br. 11 (2023). https://doi.org/10.3390/cancers15113052

Golčić, M., et al. (2023) 'Analysis of the Gut Microbiome and Dietary Habits in Metastatic Melanoma Patients with a Complete and Sustained Response to Immunotherapy', Cancers, 15(11). doi: 10.3390/cancers15113052

Golčić M, Simetić L, Herceg D, Blažičević K, Kenđel Jovanović G, Dražić I, i sur.. Analysis of the Gut Microbiome and Dietary Habits in Metastatic Melanoma Patients with a Complete and Sustained Response to Immunotherapy. Cancers [Internet]. 04.06.2023. [pristupljeno 17.10.2024.];15(11). doi: 10.3390/cancers15113052

M. Golčić, et al., "Analysis of the Gut Microbiome and Dietary Habits in Metastatic Melanoma Patients with a Complete and Sustained Response to Immunotherapy", Cancers, vol. 15, br. 11, Lipanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:044422. [Citirano: 17.10.2024.]

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Podaci o radu
Naslov (engleski)Analysis of the Gut Microbiome and Dietary Habits in Metastatic Melanoma Patients with a Complete and Sustained Response to Immunotherapy
AutorMarin Golčić
AutorLuka Simetić
AutorDavorin Herceg
AutorKrešimir Blažičević
AutorGordana Kenđel Jovanović
AutorIvan Dražić
AutorAndrej Belančić
AutorNataša Skočibušić
AutorDora Palčevski
AutorIgor Rubinić
AutorVera Vlahović-Palčevski
AutorTea Majnarić
AutorRenata Dobrila-Dintinjana
AutorStjepko Pleština
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PATOFIZIOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patofiziologija
Sažetak (engleski)
Immunotherapy has improved the prognosis of metastatic melanoma patients, although most patients do not achieve a complete response. While specific gut microbiome and dietary habits might influence treatment success, there is a lack of concordance between the studies, potentially due to dichotomizing patients only into responders and non-responders. The aim of this study was to elucidate whether metastatic melanoma patients with complete and sustained response to immunotherapy exhibit differences in gut microbiome composition among themselves, and whether those differences were associated with specific dietary habits. Shotgun metagenomic sequencing revealed that patients who exhibited a complete response after more than 9 months of treatment (late responders) exhibited a significantly higher beta-diversity (p = 0.02), with a higher abundance of Coprococcus comes (LDA 3.548, p = 0.010), Bifidobacterium pseudocatenulatum (LDA 3.392, p = 0.024), and lower abundance of Prevotellaceae (p = 0.04) compared to early responders. Furthermore, late responders exhibited a different diet profile, with a significantly lower intake of proteins and sweets and a higher intake of flavones (p < 0.05). The research showed that metastatic melanoma patients with a complete and sustained response to immunotherapy were a heterogeneous group. Patients with a late complete response exhibited microbiome and dietary habits which were previously associated with an improved response to immunotherapy.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCancers
Brojčani podacivol. 15, br. 11, 3052
e-ISSN2072-6694
DOIhttps://doi.org/10.3390/cancers15113052
URN:NBNurn:nbn:hr:105:044422
Datum objave publikacije2023-06-04
URL dokumentahttps://www.mdpi.com/2072-6694/15/11/3052
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-10-05 08:01:22