prikaz prve stranice dokumenta Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study
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Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study
The Lancet Diabetes & Endocrinology, 11 (2023), 6; 402-413. https://doi.org/10.1016/S2213-8587(23)00094-3
(THYCOVID Collaboration Group) Medas, Fabio; Dobrinja, Chiara; Al-Suhaimi, Ebtesam Abdullah; Altmeier, Julia; Anajar, Said; Arikan, Akif Enes; Azaryan, Irina; Bains, Lovenish; Basili, Giancarlo; Bolukbasi, Hakan; Bononi, Marco; Borumandi, Farzad; Bozan, Mehmet Buğra; Brenta, Gabriela; Brunaud, Laurent; Brunner, Maximilian; Buemi, Antoine; Canu, Gian Luigi; Cappellacci, Federico; Cartwright, Sara Burchfield; Castells Fusté, Ignasi; Cavalheiro, Beatriz; Cavallaro, Giuseppe; Chala, Andres; Chan, Shun Yan Bryant; Chaplin, John; Cheema, Mustafa Sajjad; Chiapponi, Costanza; Chiofalo, Maria Grazia; Chrysos, Emmanuel; D'Amore, Annamaria; de Cillia, Michael; De Crea, Carmela; de Manzini, Nicolò; de Matos, Leandro Luongo; De Pasquale, Loredana; Del Rio, Paolo; Demarchi, Marco Stefano; Dhiwakar, Muthuswamy; Donatini, Gianluca; Dora, Jose Miguel; D'Orazi, Valerio; Doulatram Gamgaram, Viyey Kishore; Eismontas, Vitalijus; Kabiri, El Hassane; El Malki, Hadj Omar; Elzahaby, Islam; Enciu, Octavian; Eskander, Antoine; Feroci, Francesco; Figueroa-Bohorquez, David; Filis, Dimitrios; Gorostidi, François; Frías-Fernández, Pedro; Gamboa-Dominguez, Armando; Genc, Volkan; Giordano, Davide; Gómez-Pedraza, Antonio; Graceffa, Giuseppa; Griffin, James; Guerreiro, Sofia Cuco; Gupta, Karan; Gupta, Keshav Kumar; Gurrado, Angela; Hajiioannou, Jiannis; Hakala, Tommi; Harahap, Wirsma Arif; Hargitai, Lindsay; Hartl, Dana; Hellmann, Andrzej; Hlozek, Jiri; Hoang, Van Trung; Iacobone, Maurizio; Innaro, Nadia; Ioannidis, Orestis; Jang, J H Isabelle; Xavier-Junior, Jose Candido; Jovanovic, Milan; Kaderli, Reto Martin; Kakamad, Fahmi; Kaliszewski, Krzysztof; Karamanliev, Martin; Katoh, Hiroshi; Košec, Andro; Kovacevic, Bozidar; Kowalski, Luiz Paulo; Králik, Robert; Yadav, Sanjay Kumar; Kumorová, Adriána; Lampridis, Savvas; Lasithiotakis, Konstantinos; Leclere, Jean-Christophe; Leong, Eugene Kwong Fei; Leow, Melvin Khee-Shing; Lim, James Y; Lino-Silva, Leonardo S; Liu, Shirley Yuk Wah; Llorach, Núria Perucho; Lombardi, Celestino Pio; López-Gómez, Javier; Lori, Eleonora; Quintanilla-Dieck, Lourdes; Lucchini, Roberta; Madani, Amin; Manatakis, Dimitrios; Markovic, Ivan; Materazzi, Gabriele; Mazeh, Haggi; Mercante, Giuseppe; Meyer-Rochow, Goswin Yason; Mihaljevic, Olgica; Miller, Julie A; Minuto, Michele; Monacelli, Massimo; Mulita, Francesk; Mullineris, Barbara; Muñoz-de-Nova, José Luis; Muradás Girardi, Fábio; Nader, Saki; Napadon, Tangjaturonrasme; Nastos, Constantinos; Offi, Chiara; Ronen, Ohad; Oragano, Luigi; Orois, Aida; Pan, Yongqin; Panagiotidis, Emmanouil; Panchangam, Ramakanth Bhargav; Papavramidis, Theodosios; Parida, Pradipta Kumar; Paspala, Anna; Pérez, Òscar Vidal; Petrovic, Sabrina; Raffaelli, Marco; Ramacciotti, Constanza Fernanda; Ratia Gimenez, Tomas; Rivo Vázquez, Ángel; Roh, Jong-Lyel; Rossi, Leonardo; Sanabria, Alvaro; Santeerapharp, Alena; Semenov, Arseny; Seneviratne, Sanjeewa; Serdar, Altinay; Sheahan, Patrick; Sheppard, Sean C; Slotcavage, Rachel L; Smaxwil, Constantin; Kim, Soo Young; Sorrenti, Salvatore; Spartalis, Eleftherios; Sriphrapradang, Chutintorn; Testini, Mario; Turk, Yigit; Tzikos, George; Vabalayte, Kristina; Vargas-Osorio, Kelly; Vázquez Rentería, Rafael Sebastián; Velázquez-Fernández, David; Vithana, Sanura Malinda Pallegoda; Yücel, Levent; Yulian, Erwin Danil; Zahradnikova, Petra; Zarogoulidis, Paul; Ziablitskaia, Evgeniia; Zolotoukho, Anna; Calò, Pietro Giorgio Više autora...

Citirajte ovaj rad

Medas, F., Dobrinja, C., Al Suhaimi, E. A., Altmeier, J., Anajar, S., Arikan, A. E. ... Calò, P. G. (2023). Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study. The Lancet Diabetes & Endocrinology, 11. (6), 402-413. doi: 10.1016/S2213-8587(23)00094-3

Medas, Fabio, et al. "Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study." The Lancet Diabetes & Endocrinology, vol. 11, br. 6, 2023, str. 402-413. https://doi.org/10.1016/S2213-8587(23)00094-3

Medas, Fabio, Chiara Dobrinja, Ebtesam Abdullah Al Suhaimi, Julia Altmeier, Said Anajar, Akif Enes Arikan, Irina Azaryan, et al. "Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study." The Lancet Diabetes & Endocrinology 11, br. 6 (2023): 402-413. https://doi.org/10.1016/S2213-8587(23)00094-3

Medas, F., et al. (2023) 'Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study', The Lancet Diabetes & Endocrinology, 11(6), str. 402-413. doi: 10.1016/S2213-8587(23)00094-3

Medas F, Dobrinja C, Al Suhaimi EA, Altmeier J, Anajar S, Arikan AE, i sur.. Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study. The Lancet Diabetes & Endocrinology [Internet]. 06.2023. [pristupljeno 15.04.2024.];11(6):402-413. doi: 10.1016/S2213-8587(23)00094-3

F. Medas, et al., "Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study", The Lancet Diabetes & Endocrinology, vol. 11, br. 6, str. 402-413, Lipanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:126364. [Citirano: 15.04.2024.]

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Naslov (engleski)Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study
AutorFabio Medas
AutorChiara Dobrinja
AutorEbtesam Abdullah Al-Suhaimi
AutorJulia Altmeier
AutorSaid Anajar
AutorAkif Enes Arikan
AutorIrina Azaryan
AutorLovenish Bains
AutorGiancarlo Basili
AutorHakan Bolukbasi
AutorMarco Bononi
AutorFarzad Borumandi
AutorMehmet Buğra Bozan
AutorGabriela Brenta
AutorLaurent Brunaud
AutorMaximilian Brunner
AutorAntoine Buemi
AutorGian Luigi Canu
AutorFederico Cappellacci
AutorSara Burchfield Cartwright
AutorIgnasi Castells Fusté
AutorBeatriz Cavalheiro
AutorGiuseppe Cavallaro
AutorAndres Chala
AutorShun Yan Bryant Chan
AutorJohn Chaplin
AutorMustafa Sajjad Cheema
AutorCostanza Chiapponi
AutorMaria Grazia Chiofalo
AutorEmmanuel Chrysos
AutorAnnamaria D'Amore
AutorMichael de Cillia
AutorCarmela De Crea
AutorNicolò de Manzini
AutorLeandro Luongo de Matos
AutorLoredana De Pasquale
AutorPaolo Del Rio
AutorMarco Stefano Demarchi
AutorMuthuswamy Dhiwakar
AutorGianluca Donatini
AutorJose Miguel Dora
AutorValerio D'Orazi
AutorViyey Kishore Doulatram Gamgaram
AutorVitalijus Eismontas
AutorEl Hassane Kabiri
AutorHadj Omar El Malki
AutorIslam Elzahaby
AutorOctavian Enciu
AutorAntoine Eskander
AutorFrancesco Feroci
AutorDavid Figueroa-Bohorquez
AutorDimitrios Filis
AutorFrançois Gorostidi
AutorPedro Frías-Fernández
AutorArmando Gamboa-Dominguez
AutorVolkan Genc
AutorDavide Giordano
AutorAntonio Gómez-Pedraza
AutorGiuseppa Graceffa
AutorJames Griffin
AutorSofia Cuco Guerreiro
AutorKaran Gupta
AutorKeshav Kumar Gupta
AutorAngela Gurrado
AutorJiannis Hajiioannou
AutorTommi Hakala
AutorWirsma Arif Harahap
AutorLindsay Hargitai
AutorDana Hartl
AutorAndrzej Hellmann
AutorJiri Hlozek
AutorVan Trung Hoang
AutorMaurizio Iacobone
AutorNadia Innaro
AutorOrestis Ioannidis
AutorJ H Isabelle Jang
AutorJose Candido Xavier-Junior
AutorMilan Jovanovic
AutorReto Martin Kaderli
AutorFahmi Kakamad
AutorKrzysztof Kaliszewski
AutorMartin Karamanliev
AutorHiroshi Katoh
AutorAndro Košec
AutorBozidar Kovacevic
AutorLuiz Paulo Kowalski
AutorRobert Králik
AutorSanjay Kumar Yadav
AutorAdriána Kumorová
AutorSavvas Lampridis
AutorKonstantinos Lasithiotakis
AutorJean-Christophe Leclere
AutorEugene Kwong Fei Leong
AutorMelvin Khee-Shing Leow
AutorJames Y Lim
AutorLeonardo S Lino-Silva
AutorShirley Yuk Wah Liu
AutorNúria Perucho Llorach
AutorCelestino Pio Lombardi
AutorJavier López-Gómez
AutorEleonora Lori
AutorLourdes Quintanilla-Dieck
AutorRoberta Lucchini
AutorAmin Madani
AutorDimitrios Manatakis
AutorIvan Markovic
AutorGabriele Materazzi
AutorHaggi Mazeh
AutorGiuseppe Mercante
AutorGoswin Yason Meyer-Rochow
AutorOlgica Mihaljevic
AutorJulie A Miller
AutorMichele Minuto
AutorMassimo Monacelli
AutorFrancesk Mulita
AutorBarbara Mullineris
AutorJosé Luis Muñoz-de-Nova
AutorFábio Muradás Girardi
AutorSaki Nader
AutorTangjaturonrasme Napadon
AutorConstantinos Nastos
AutorChiara Offi
AutorOhad Ronen
AutorLuigi Oragano
AutorAida Orois
AutorYongqin Pan
AutorEmmanouil Panagiotidis
AutorRamakanth Bhargav Panchangam
AutorTheodosios Papavramidis
AutorPradipta Kumar Parida
AutorAnna Paspala
AutorÒscar Vidal Pérez
AutorSabrina Petrovic
AutorMarco Raffaelli
AutorConstanza Fernanda Ramacciotti
AutorTomas Ratia Gimenez
AutorÁngel Rivo Vázquez
AutorJong-Lyel Roh
AutorLeonardo Rossi
AutorAlvaro Sanabria
AutorAlena Santeerapharp
AutorArseny Semenov
AutorSanjeewa Seneviratne
AutorAltinay Serdar
AutorPatrick Sheahan
AutorSean C Sheppard
AutorRachel L Slotcavage
AutorConstantin Smaxwil
AutorSoo Young Kim
AutorSalvatore Sorrenti
AutorEleftherios Spartalis
AutorChutintorn Sriphrapradang
AutorMario Testini
AutorYigit Turk
AutorGeorge Tzikos
AutorKristina Vabalayte
AutorKelly Vargas-Osorio
AutorRafael Sebastián Vázquez Rentería
AutorDavid Velázquez-Fernández
AutorSanura Malinda Pallegoda Vithana
AutorLevent Yücel
AutorErwin Danil Yulian
AutorPetra Zahradnikova
AutorPaul Zarogoulidis
AutorEvgeniia Ziablitskaia
AutorAnna Zolotoukho
AutorPietro Giorgio Calò
KolaboracijaTHYCOVID Collaboration Group
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA OTORINOLARINGOLOGIJU I KIRURGIJU GLAVE I VRATA)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Otorinolaringologija
Sažetak (engleski)
Background: Since its outbreak in early 2020, the COVID-19 pandemic has diverted resources from non-urgent and elective procedures, leading to diagnosis and treatment delays, with an increased number of neoplasms at advanced stages worldwide. The aims of this study were to quantify the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic; and to evaluate whether delays in surgery led to an increased occurrence of aggressive tumours. Methods: In this retrospective, international, cross-sectional study, centres were invited to participate in June 22, 2022; each centre joining the study was asked to provide data from medical records on all surgical thyroidectomies consecutively performed from Jan 1, 2019, to Dec 31, 2021. Patients with indeterminate thyroid nodules were divided into three groups according to when they underwent surgery: from Jan 1, 2019, to Feb 29, 2020 (global prepandemic phase), from March 1, 2020, to May 31, 2021 (pandemic escalation phase), and from June 1 to Dec 31, 2021 (pandemic decrease phase). The main outcomes were, for each phase, the number of surgeries for indeterminate thyroid nodules, and in patients with a postoperative diagnosis of thyroid cancers, the occurrence of tumours larger than 10 mm, extrathyroidal extension, lymph node metastases, vascular invasion, distant metastases, and tumours at high risk of structural disease recurrence. Univariate analysis was used to compare the probability of aggressive thyroid features between the first and third study phases. The study was registered on ClinicalTrials.gov, NCT05178186. Findings: Data from 157 centres (n=49 countries) on 87 467 patients who underwent surgery for benign and malignant thyroid disease were collected, of whom 22 974 patients (18 052 [78·6%] female patients and 4922 [21·4%] male patients) received surgery for indeterminate thyroid nodules. We observed a significant reduction in surgery for indeterminate thyroid nodules during the pandemic escalation phase (median monthly surgeries per centre, 1·4 [IQR 0·6-3·4]) compared with the prepandemic phase (2·0 [0·9-3·7]; p<0·0001) and pandemic decrease phase (2·3 [1·0-5·0]; p<0·0001). Compared with the prepandemic phase, in the pandemic decrease phase we observed an increased occurrence of thyroid tumours larger than 10 mm (2554 [69·0%] of 3704 vs 1515 [71·5%] of 2119; OR 1·1 [95% CI 1·0-1·3]; p=0·042), lymph node metastases (343 [9·3%] vs 264 [12·5%]; OR 1·4 [1·2-1·7]; p=0·0001), and tumours at high risk of structural disease recurrence (203 [5·7%] of 3584 vs 155 [7·7%] of 2006; OR 1·4 [1·1-1·7]; p=0·0039). Interpretation: Our study suggests that the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic period could have led to an increased occurrence of aggressive thyroid tumours. However, other compelling hypotheses, including increased selection of patients with aggressive malignancies during this period, should be considered. We suggest that surgery for indeterminate thyroid nodules should no longer be postponed even in future instances of pandemic escalation.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaThe Lancet Diabetes & Endocrinology
Brojčani podacivol. 11, br. 6, str. 402-413
p-ISSN2213-8587
DOIhttps://doi.org/10.1016/S2213-8587(23)00094-3
URN:NBNurn:nbn:hr:105:126364
Datum objave publikacije2023-06
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S2213858723000943
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-11-13 08:40:29