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Wnt Signaling Inhibitors and Their Promising Role in Tumor Treatment
International Journal of Molecular Sciences, 24 (2023), 7; 6733. https://doi.org/10.3390/ijms24076733
Pećina-Šlaus, Nives; Aničić, Sara; Bukovac, Anja; Kafka, Anja

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Pećina Šlaus, N., Aničić, S., Bukovac, A. i Kafka, A. (2023). Wnt Signaling Inhibitors and Their Promising Role in Tumor Treatment. International Journal of Molecular Sciences, 24. (7). doi: 10.3390/ijms24076733

Pećina Šlaus, Nives, et al. "Wnt Signaling Inhibitors and Their Promising Role in Tumor Treatment." International Journal of Molecular Sciences, vol. 24, br. 7, 2023. https://doi.org/10.3390/ijms24076733

Pećina Šlaus, Nives, Sara Aničić, Anja Bukovac i Anja Kafka. "Wnt Signaling Inhibitors and Their Promising Role in Tumor Treatment." International Journal of Molecular Sciences 24, br. 7 (2023). https://doi.org/10.3390/ijms24076733

Pećina Šlaus, N., et al. (2023) 'Wnt Signaling Inhibitors and Their Promising Role in Tumor Treatment', International Journal of Molecular Sciences, 24(7). doi: 10.3390/ijms24076733

Pećina Šlaus N, Aničić S, Bukovac A, Kafka A. Wnt Signaling Inhibitors and Their Promising Role in Tumor Treatment. International Journal of Molecular Sciences [Internet]. 04.04.2023. [pristupljeno 24.04.2024.];24(7). doi: 10.3390/ijms24076733

N. Pećina Šlaus, S. Aničić, A. Bukovac i A. Kafka, "Wnt Signaling Inhibitors and Their Promising Role in Tumor Treatment", International Journal of Molecular Sciences, vol. 24, br. 7, Travanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:746939. [Citirano: 24.04.2024.]

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Podaci o radu
Naslov (engleski)Wnt Signaling Inhibitors and Their Promising Role in Tumor Treatment
AutorNives Pećina-Šlaus
AutorSara Aničić
AutorAnja Bukovac
AutorAnja Kafka
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA FIZIOLOGIJU I IMUNOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU BIOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Fiziologija čovjeka
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Citologija, histologija i embriologija
Sažetak (engleski)
In a continuous search for the improvement of antitumor therapies, the inhibition of the Wnt signaling pathway has been recognized as a promising target. The altered functioning of the Wnt signaling in human tumors points to the strategy of the inhibition of its activity that would impact the clinical outcomes and survival of patients. Because the Wnt pathway is often mutated or epigenetically altered in tumors, which promotes its activation, inhibitors of Wnt signaling are being intensively investigated. It has been shown that knocking down specific components of the Wnt pathway has inhibitory effects on tumor growth in vivo and in vitro. Thus, similar effects are expected from the application of Wnt inhibitors. In the last decades, molecules acting as inhibitors on the pathway’s specific molecular levels have been identified and characterized. This review will discuss the inhibitors of the canonical Wnt pathway, summarize knowledge on their effectiveness as therapeutics, and debate their side effects. The role of the components frequently mutated in various tumors that are principal targets for Wnt inhibitors is also going to be brought to the reader’s attention. Some of the molecules identified as Wnt pathway inhibitors have reached early stages of clinical trials, and some have only just been discovered. All things considered, inhibition of the Wnt signaling pathway shows potential for the development of future therapies.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 24, br. 7, 6733
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms24076733
URN:NBNurn:nbn:hr:105:746939
Datum objave publikacije2023-04-04
URL dokumentahttps://www.mdpi.com/1422-0067/24/7/6733
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-11-24 11:20:28