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The Association of the Polymorphisms in the FUT8-Related Locus with the Plasma Glycosylation in Post-Traumatic Stress Disorder
International Journal of Molecular Sciences, 24 (2023), 6; 5706. https://doi.org/10.3390/ijms24065706
Tudor, Lucija; Nedić Erjavec, Gordana; Nikolac Perković, Matea; Konjevod, Marcela; Uzun, Suzana; Kozumplik, Oliver; Mimica, Ninoslav; Lauc, Gordan; Švob Štrac, Dubravka; Pivac, Nela

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Tudor, L., Nedić Erjavec, G., Nikolac Perković, M., Konjevod, M., Uzun, S., Kozumplik, O. ... Pivac, N. (2023). The Association of the Polymorphisms in the FUT8-Related Locus with the Plasma Glycosylation in Post-Traumatic Stress Disorder. International Journal of Molecular Sciences, 24. (6). doi: 10.3390/ijms24065706

Tudor, Lucija, et al. "The Association of the Polymorphisms in the FUT8-Related Locus with the Plasma Glycosylation in Post-Traumatic Stress Disorder." International Journal of Molecular Sciences, vol. 24, br. 6, 2023. https://doi.org/10.3390/ijms24065706

Tudor, Lucija, Gordana Nedić Erjavec, Matea Nikolac Perković, Marcela Konjevod, Suzana Uzun, Oliver Kozumplik, Ninoslav Mimica, Gordan Lauc, Dubravka Švob Štrac i Nela Pivac. "The Association of the Polymorphisms in the FUT8-Related Locus with the Plasma Glycosylation in Post-Traumatic Stress Disorder." International Journal of Molecular Sciences 24, br. 6 (2023). https://doi.org/10.3390/ijms24065706

Tudor, L., et al. (2023) 'The Association of the Polymorphisms in the FUT8-Related Locus with the Plasma Glycosylation in Post-Traumatic Stress Disorder', International Journal of Molecular Sciences, 24(6). doi: 10.3390/ijms24065706

Tudor L, Nedić Erjavec G, Nikolac Perković M, Konjevod M, Uzun S, Kozumplik O, i sur.. The Association of the Polymorphisms in the FUT8-Related Locus with the Plasma Glycosylation in Post-Traumatic Stress Disorder. International Journal of Molecular Sciences [Internet]. 16.03.2023. [pristupljeno 18.04.2024.];24(6). doi: 10.3390/ijms24065706

L. Tudor, et al., "The Association of the Polymorphisms in the FUT8-Related Locus with the Plasma Glycosylation in Post-Traumatic Stress Disorder", International Journal of Molecular Sciences, vol. 24, br. 6, Ožujak 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:949087. [Citirano: 18.04.2024.]

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Naslov (engleski)The Association of the Polymorphisms in the FUT8-Related Locus with the Plasma Glycosylation in Post-Traumatic Stress Disorder
AutorLucija Tudor
AutorGordana Nedić Erjavec
AutorMatea Nikolac Perković
AutorMarcela Konjevod
AutorSuzana Uzun
AutorOliver Kozumplik
AutorNinoslav Mimica
AutorGordan Lauc
AutorDubravka Švob Štrac
AutorNela Pivac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PSIHIJATRIJU I PSIHOLOŠKU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Sažetak (engleski)
The molecular underpinnings of post-traumatic stress disorder (PTSD) are still unclear due to the complex interactions of genetic, psychological, and environmental factors. Glycosylation is a common post-translational modification of proteins, and different pathophysiological states, such as inflammation, autoimmune diseases, and mental disorders including PTSD, show altered N-glycome. Fucosyltransferase 8 (FUT8) is the enzyme that catalyzes the addition of core fucose on glycoproteins, and mutations in the FUT8 gene are associated with defects in glycosylation and functional abnormalities. This is the first study that investigated the associations of plasma N-glycan levels with FUT8-related rs6573604, rs11621121, rs10483776, and rs4073416 polymorphisms and their haplotypes in 541 PTSD patients and control participants. The results demonstrated that the rs6573604 T allele was more frequent in the PTSD than in the control participants. Significant associations of plasma N-glycan levels with PTSD and FUT8-related polymorphisms were observed. We also detected associations of rs11621121 and rs10483776 polymorphisms and their haplotypes with plasma levels of specific N-glycan species in both the control and PTSD groups. In carriers of different rs6573604 and rs4073416 genotypes and alleles, differences in plasma N-glycan levels were only found in the control group. These molecular findings suggest a possible regulatory role of FUT8-related polymorphisms in glycosylation, the alternations of which could partially explain the development and clinical manifestation of PTSD.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 24, br. 6, 5706
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms24065706
URN:NBNurn:nbn:hr:105:949087
Datum objave publikacije2023-03-16
URL dokumentahttps://www.mdpi.com/1422-0067/24/6/5706
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-01-08 12:20:14