prikaz prve stranice dokumenta Interleukin-2 gene methylation levels and interleukin-2 levels associated with environmental exposure as risk biomarkers for preterm birth
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Interleukin-2 gene methylation levels and interleukin-2 levels associated with environmental exposure as risk biomarkers for preterm birth
Croatian Medical Journal, 64 (2023), 5; 320-328. https://doi.org/10.3325/cmj.2023.64.320
Fučić, Aleksandra; Knežević, Jelena; Krasić, Jure; Polančec, Denis; Sinčić, Nino; Sindičić Dessardo, Nada; Starčević, Mirta; Guszak, Vedrana; Ceppi, Marcello; Bruzzone, Marco

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Fučić, A., Knežević, J., Krasić, J., Polančec, D., Sinčić, N., Sindičić Dessardo, N. ... Bruzzone, M. (2023). Interleukin-2 gene methylation levels and interleukin-2 levels associated with environmental exposure as risk biomarkers for preterm birth. Croatian Medical Journal, 64. (5), 320-328. doi: 10.3325/cmj.2023.64.320

Fučić, Aleksandra, et al. "Interleukin-2 gene methylation levels and interleukin-2 levels associated with environmental exposure as risk biomarkers for preterm birth." Croatian Medical Journal, vol. 64, br. 5, 2023, str. 320-328. https://doi.org/10.3325/cmj.2023.64.320

Fučić, Aleksandra, Jelena Knežević, Jure Krasić, Denis Polančec, Nino Sinčić, Nada Sindičić Dessardo, Mirta Starčević, Vedrana Guszak, Marcello Ceppi i Marco Bruzzone. "Interleukin-2 gene methylation levels and interleukin-2 levels associated with environmental exposure as risk biomarkers for preterm birth." Croatian Medical Journal 64, br. 5 (2023): 320-328. https://doi.org/10.3325/cmj.2023.64.320

Fučić, A., et al. (2023) 'Interleukin-2 gene methylation levels and interleukin-2 levels associated with environmental exposure as risk biomarkers for preterm birth', Croatian Medical Journal, 64(5), str. 320-328. doi: 10.3325/cmj.2023.64.320

Fučić A, Knežević J, Krasić J, Polančec D, Sinčić N, Sindičić Dessardo N, i sur.. Interleukin-2 gene methylation levels and interleukin-2 levels associated with environmental exposure as risk biomarkers for preterm birth. Croatian Medical Journal [Internet]. 31.10.2023. [pristupljeno 08.11.2024.];64(5):320-328. doi: 10.3325/cmj.2023.64.320

A. Fučić, et al., "Interleukin-2 gene methylation levels and interleukin-2 levels associated with environmental exposure as risk biomarkers for preterm birth", Croatian Medical Journal, vol. 64, br. 5, str. 320-328, Listopad 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:490836. [Citirano: 08.11.2024.]

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Naslov (engleski)Interleukin-2 gene methylation levels and interleukin-2 levels associated with environmental exposure as risk biomarkers for preterm birth
AutorAleksandra Fučić
AutorJelena Knežević
AutorJure Krasić
AutorDenis Polančec
AutorNino Sinčić
AutorNada Sindičić Dessardo
AutorMirta Starčević
AutorVedrana Guszak
AutorMarcello Ceppi
AutorMarco Bruzzone
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU BIOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Aim: To compare interleukin-2 levels (IL-2) and IL-2 gene site 1 methylation levels between preterm newborns (PN) and full-term newborns (FN) and investigate their association with the environmental exposure of their mothers during pregnancy. Methods: IL-2 and IL-2 gene site 1 methylation levels were assessed in 50 PN and 56 FN. Newborns' mothers filled in questionnaires about their living and occupational environments, habits, diets, and hobbies. Results: The mothers of PN were significantly more frequently agrarian/rural residents than the mothers of FN. PN had significantly higher IL-2 levels, and significantly lower methylation of IL-2 gene site 1 levels than FN. Conclusion: IL-2 levels, hypomethylation of the IL-2 gene site 1, and the mother's rural residence (probably due to pesticide exposure) were predictive biomarkers for preterm birth. For the first time, we present the reference values for the methylation of IL-2 gene site 1 in PN and FN, which can be used in the clinical setting and biomonitoring.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 64, br. 5, str. 320-328
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2023.64.320
URN:NBNurn:nbn:hr:105:490836
Datum objave publikacije2023-10-31
URL dokumentahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668044/
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2024-01-09 12:38:32