prikaz prve stranice dokumenta Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis
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Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis
Multiple Sclerosis Journal, 29 (2023), 7; 875-883. https://doi.org/10.1177/13524585231151951
Daruwalla, Cyrus; Shaygannejad, Vahid; Ozakbas, Serkan; Havrdova, Eva Kubala; Horakova, Dana; Alroughani, Raed; Boz, Cavit; Patti, Francesco; Onofrj, Marco; Lugaresi, Alessandra; Eichau, Sara; Girard, Marc; Prat, Alexandre; Duquette, Pierre; Yamout, Bassem; Khoury, Samia J; Sajedi, Seyed Aidin; Turkoglu, Recai; Altintas, Ayse; Skibina, Olga; Buzzard, Katherine; Grammond, Pierre; Karabudak, Rana; van der Walt, Anneke; Butzkueven, Helmut; Maimone, Davide; Lechner-Scott, Jeannette; Soysal, Aysun; John, Nevin; Prevost, Julie; Spitaleri, Daniele; Ramo-Tello, Cristina; Gerlach, Oliver; Iuliano, Gerardo; Foschi, Matteo; Ampapa, Radek; van Pesch, Vincent; Barnett, Michael; Shalaby, Nevin; D’hooghe, Marie; Kuhle, Jens; Sa, Maria Jose; Fabis-Pedrini, Marzena; Kermode, Allan; Mrabet, Saloua; Gouider, Riadh; Hodgkinson, Suzanne; Laureys, Guy; Van Hijfte, Liesbeth; Macdonell, Richard; Oreja-Guevara, Celia; Cristiano, Edgardo; McCombe, Pamela; Sanchez-Menoyo, Jose Luis; Singhal, Bhim; Blanco, Yolanda; Hughes, Stella; Garber, Justin; Solaro, Claudio; McGuigan, Chris; Taylor, Bruce; de Gans, Koen; Habek, Mario; Al-Asmi, Abdullah; Mihaela, Simu; Castillo Triviño, Tamara; Al-Harbi, Talal; Rojas, Juan Ignacio; Gray, Orla; Khurana, Dheeraj; Van Wijmeersch, Bart; Grigoriadis, Nikolaos; Inshasi, Jihad; Oh, Jiwon; Aguera-Morales, Eduardo; Fragoso, Yara; Moore, Fraser; Shaw, Cameron; Baghbanian, Seyed Mohammad; Shuey, Neil; Willekens, Barbara; Hardy, Todd A; Decoo, Danny; sempere, Angel Perez; Field, Deborah; Wynford-Thomas, Ray; Cunniffe, Nick G; Roos, Izanne; Malpas, Charles B; Coles, Alasdair J; Kalincik, Tomas; Brown, J William L Više autora...

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Daruwalla, C., Shaygannejad, V., Ozakbas, S., Havrdova, E. K., Horakova, D., Alroughani, R. ... Brown, J. W. L. (2023). Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis. Multiple Sclerosis Journal, 29. (7), 875-883. doi: 10.1177/13524585231151951

Daruwalla, Cyrus, et al. "Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis." Multiple Sclerosis Journal, vol. 29, br. 7, 2023, str. 875-883. https://doi.org/10.1177/13524585231151951

Daruwalla, Cyrus, Vahid Shaygannejad, Serkan Ozakbas, Eva Kubala Havrdova, Dana Horakova, Raed Alroughani, Cavit Boz, et al. "Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis." Multiple Sclerosis Journal 29, br. 7 (2023): 875-883. https://doi.org/10.1177/13524585231151951

Daruwalla, C., et al. (2023) 'Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis', Multiple Sclerosis Journal, 29(7), str. 875-883. doi: 10.1177/13524585231151951

Daruwalla C, Shaygannejad V, Ozakbas S, Havrdova EK, Horakova D, Alroughani R, i sur.. Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis. Multiple Sclerosis Journal [Internet]. 27.02.2023. [pristupljeno 20.04.2024.];29(7):875-883. doi: 10.1177/13524585231151951

C. Daruwalla, et al., "Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis", Multiple Sclerosis Journal, vol. 29, br. 7, str. 875-883, Veljača 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:737222. [Citirano: 20.04.2024.]

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Naslov (engleski)Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis
AutorCyrus Daruwalla
AutorVahid Shaygannejad
AutorSerkan Ozakbas
AutorEva Kubala Havrdova
AutorDana Horakova
AutorRaed Alroughani
AutorCavit Boz
AutorFrancesco Patti
AutorMarco Onofrj
AutorAlessandra Lugaresi
AutorSara Eichau
AutorMarc Girard
AutorAlexandre Prat
AutorPierre Duquette
AutorBassem Yamout
AutorSamia J Khoury
AutorSeyed Aidin Sajedi
AutorRecai Turkoglu
AutorAyse Altintas
AutorOlga Skibina
AutorKatherine Buzzard
AutorPierre Grammond
AutorRana Karabudak
AutorAnneke van der Walt
AutorHelmut Butzkueven
AutorDavide Maimone
AutorJeannette Lechner-Scott
AutorAysun Soysal
AutorNevin John
AutorJulie Prevost
AutorDaniele Spitaleri
AutorCristina Ramo-Tello
AutorOliver Gerlach
AutorGerardo Iuliano
AutorMatteo Foschi
AutorRadek Ampapa
AutorVincent van Pesch
AutorMichael Barnett
AutorNevin Shalaby
AutorMarie D’hooghe
AutorJens Kuhle
AutorMaria Jose Sa
AutorMarzena Fabis-Pedrini
AutorAllan Kermode
AutorSaloua Mrabet
AutorRiadh Gouider
AutorSuzanne Hodgkinson
AutorGuy Laureys
AutorLiesbeth Van Hijfte
AutorRichard Macdonell
AutorCelia Oreja-Guevara
AutorEdgardo Cristiano
AutorPamela McCombe
AutorJose Luis Sanchez-Menoyo
AutorBhim Singhal
AutorYolanda Blanco
AutorStella Hughes
AutorJustin Garber
AutorClaudio Solaro
AutorChris McGuigan
AutorBruce Taylor
AutorKoen de Gans
AutorMario Habek
AutorAbdullah Al-Asmi
AutorSimu Mihaela
AutorTamara Castillo Triviño
AutorTalal Al-Harbi
AutorJuan Ignacio Rojas
AutorOrla Gray
AutorDheeraj Khurana
AutorBart Van Wijmeersch
AutorNikolaos Grigoriadis
AutorJihad Inshasi
AutorJiwon Oh
AutorEduardo Aguera-Morales
AutorYara Fragoso
AutorFraser Moore
AutorCameron Shaw
AutorSeyed Mohammad Baghbanian
AutorNeil Shuey
AutorBarbara Willekens
AutorTodd A Hardy
AutorDanny Decoo
AutorAngel Perez sempere
AutorDeborah Field
AutorRay Wynford-Thomas
AutorNick G Cunniffe
AutorIzanne Roos
AutorCharles B Malpas
AutorAlasdair J Coles
AutorTomas Kalincik
AutorJ William L Brown
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA NEUROLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Neurologija
Sažetak (engleski)
Background: The prognostic significance of non-disabling relapses in people with relapsing-remitting multiple sclerosis (RRMS) is unclear. Objective: To determine whether early non-disabling relapses predict disability accumulation in RRMS. Methods: We redefined mild relapses in MSBase as 'non-disabling', and moderate or severe relapses as 'disabling'. We used mixed-effects Cox models to compare 90-day confirmed disability accumulation events in people with exclusively non-disabling relapses within 2 years of RRMS diagnosis to those with no early relapses; and any early disabling relapses. Analyses were stratified by disease-modifying therapy (DMT) efficacy during follow-up. Results: People who experienced non-disabling relapses within 2 years of RRMS diagnosis accumulated more disability than those with no early relapses if they were untreated (n = 285 vs 4717; hazard ratio (HR) = 1.29, 95% confidence interval (CI) = 1.00-1.68) or given platform DMTs (n = 1074 vs 7262; HR = 1.33, 95% CI = 1.15-1.54), but not if given high-efficacy DMTs (n = 572 vs 3534; HR = 0.90, 95% CI = 0.71-1.13) during follow-up. Differences in disability accumulation between those with early non-disabling relapses and those with early disabling relapses were not confirmed statistically. Conclusion: This study suggests that early non-disabling relapses are associated with a higher risk of disability accumulation than no early relapses in RRMS. This risk may be mitigated by high-efficacy DMTs. Therefore, non-disabling relapses should be considered when making treatment decisions.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMultiple Sclerosis Journal
Brojčani podacivol. 29, br. 7, str. 875-883
p-ISSN1352-4585
e-ISSN1477-0970
DOIhttps://doi.org/10.1177/13524585231151951
URN:NBNurn:nbn:hr:105:737222
Datum objave publikacije2023-02-27
URL dokumentahttp://journals.sagepub.com/doi/10.1177/13524585231151951
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-01-11 12:06:47