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The Associations of Neutrophil–Lymphocyte, Platelet–Lymphocyte, Monocyte–Lymphocyte Ratios and Immune-Inflammation Index with Negative Symptoms in Patients with Schizophrenia
Biomolecules, 13 (2023), 2; 297. https://doi.org/10.3390/biom13020297
Šagud, Marina; Madžarac, Zoran; Nedić Erjavec, Gordana; Šimunović Filipčić, Ivona; Mikulić, Filip Luka; Rogić, Dunja; Bradaš, Zoran; Bajs Janović, Maja; Pivac, Nela

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Šagud, M., Madžarac, Z., Nedić Erjavec, G., Šimunović Filipčić, I., Mikulić, F. L., Rogić, D. ... Pivac, N. (2023). The Associations of Neutrophil–Lymphocyte, Platelet–Lymphocyte, Monocyte–Lymphocyte Ratios and Immune-Inflammation Index with Negative Symptoms in Patients with Schizophrenia. Biomolecules, 13. (2). doi: 10.3390/biom13020297

Šagud, Marina, et al. "The Associations of Neutrophil–Lymphocyte, Platelet–Lymphocyte, Monocyte–Lymphocyte Ratios and Immune-Inflammation Index with Negative Symptoms in Patients with Schizophrenia." Biomolecules, vol. 13, br. 2, 2023. https://doi.org/10.3390/biom13020297

Šagud, Marina, Zoran Madžarac, Gordana Nedić Erjavec, Ivona Šimunović Filipčić, Filip Luka Mikulić, Dunja Rogić, Zoran Bradaš, Maja Bajs Janović i Nela Pivac. "The Associations of Neutrophil–Lymphocyte, Platelet–Lymphocyte, Monocyte–Lymphocyte Ratios and Immune-Inflammation Index with Negative Symptoms in Patients with Schizophrenia." Biomolecules 13, br. 2 (2023). https://doi.org/10.3390/biom13020297

Šagud, M., et al. (2023) 'The Associations of Neutrophil–Lymphocyte, Platelet–Lymphocyte, Monocyte–Lymphocyte Ratios and Immune-Inflammation Index with Negative Symptoms in Patients with Schizophrenia', Biomolecules, 13(2). doi: 10.3390/biom13020297

Šagud M, Madžarac Z, Nedić Erjavec G, Šimunović Filipčić I, Mikulić FL, Rogić D, i sur.. The Associations of Neutrophil–Lymphocyte, Platelet–Lymphocyte, Monocyte–Lymphocyte Ratios and Immune-Inflammation Index with Negative Symptoms in Patients with Schizophrenia. Biomolecules [Internet]. 04.02.2023. [pristupljeno 12.04.2024.];13(2). doi: 10.3390/biom13020297

M. Šagud, et al., "The Associations of Neutrophil–Lymphocyte, Platelet–Lymphocyte, Monocyte–Lymphocyte Ratios and Immune-Inflammation Index with Negative Symptoms in Patients with Schizophrenia", Biomolecules, vol. 13, br. 2, Veljača 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:162116. [Citirano: 12.04.2024.]

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Podaci o radu
Naslov (engleski)The Associations of Neutrophil–Lymphocyte, Platelet–Lymphocyte, Monocyte–Lymphocyte Ratios and Immune-Inflammation Index with Negative Symptoms in Patients with Schizophrenia
AutorMarina Šagud
AutorZoran Madžarac
AutorGordana Nedić Erjavec
AutorIvona Šimunović Filipčić
AutorFilip Luka Mikulić
AutorDunja Rogić
AutorZoran Bradaš
AutorMaja Bajs Janović
AutorNela Pivac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PSIHIJATRIJU I PSIHOLOŠKU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Sažetak (engleski)
Neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), monocyte–lymphocyte ratio (MLR) and systemic immune-inflammation index (SII index) are increasingly used as indicators of inflammation in different conditions, including schizophrenia. However, their relationship with negative symptoms, including anhedonia, is largely unknown. Included were 200 patients with schizophrenia and 134 healthy controls (HC), assessed for physical anhedonia (PA), using the Revised Physical Anhedonia Scale (RPAS), and social anhedonia (SA) by the Revised Social Anhedonia Scale (RSAS). Patients were rated by the Positive and Negative Syndrome Scale (PANSS), the Clinical Assessment Interview for Negative Symptoms (CAINS) and the Brief Negative Symptom Scale (BNSS). Most of the negative symptoms were in a weak to moderate positive correlations with blood cell inflammatory ratios, namely, between NLR and MLR with PANSS negative scale, CAINS, and BNSS, and in male patients, between PLR and PANSS negative scale and CAINS. Fewer correlations were detected in females, but also in a positive direction. An exception was SA, given the negative correlation between its severity and the SII index in females, and its presence and higher PLR in males. While different negative symptoms were associated with subclinical inflammation, the relationship between SA and lower inflammatory markers deserves further exploration.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomolecules
Brojčani podacivol. 13, br. 2, 297
e-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom13020297
URN:NBNurn:nbn:hr:105:162116
Datum objave publikacije2023-02-04
ProjektŠifra: 098-0982522-2455
Naziv (hrvatski): Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja
Naziv (engleski): Molecular basis and treatment of psychiatric and stress related disorders
Voditelj: Nela Pivac
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttps://www.mdpi.com/2218-273X/13/2/297
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-01-15 08:53:16