prikaz prve stranice dokumenta Relationship of Glucose, C-peptide, Leptin, and BDNF in Maternal and Umbilical Vein Blood in Type-1 Diabetes
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Relationship of Glucose, C-peptide, Leptin, and BDNF in Maternal and Umbilical Vein Blood in Type-1 Diabetes
Nutrients, 15 (2023), 3; 600. https://doi.org/10.3390/nu15030600
Đelmiš, Josip; Orešković, Slavko; Elveđi Gašparović, Vesna; Starčević, Mirta; Herman, Mislav; Dessardo, Nada; Starčević, Vito; Ivanišević, Marina

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Đelmiš, J., Orešković, S., Elveđi Gašparović, V., Starčević, M., Herman, M., Dessardo, N. ... Ivanišević, M. (2023). Relationship of Glucose, C-peptide, Leptin, and BDNF in Maternal and Umbilical Vein Blood in Type-1 Diabetes. Nutrients, 15. (3). doi: 10.3390/nu15030600

Đelmiš, Josip, et al. "Relationship of Glucose, C-peptide, Leptin, and BDNF in Maternal and Umbilical Vein Blood in Type-1 Diabetes." Nutrients, vol. 15, br. 3, 2023. https://doi.org/10.3390/nu15030600

Đelmiš, Josip, Slavko Orešković, Vesna Elveđi Gašparović, Mirta Starčević, Mislav Herman, Nada Dessardo, Vito Starčević i Marina Ivanišević. "Relationship of Glucose, C-peptide, Leptin, and BDNF in Maternal and Umbilical Vein Blood in Type-1 Diabetes." Nutrients 15, br. 3 (2023). https://doi.org/10.3390/nu15030600

Đelmiš, J., et al. (2023) 'Relationship of Glucose, C-peptide, Leptin, and BDNF in Maternal and Umbilical Vein Blood in Type-1 Diabetes', Nutrients, 15(3). doi: 10.3390/nu15030600

Đelmiš J, Orešković S, Elveđi Gašparović V, Starčević M, Herman M, Dessardo N, i sur.. Relationship of Glucose, C-peptide, Leptin, and BDNF in Maternal and Umbilical Vein Blood in Type-1 Diabetes. Nutrients [Internet]. 24.01.2023. [pristupljeno 26.04.2024.];15(3). doi: 10.3390/nu15030600

J. Đelmiš, et al., "Relationship of Glucose, C-peptide, Leptin, and BDNF in Maternal and Umbilical Vein Blood in Type-1 Diabetes", Nutrients, vol. 15, br. 3, Siječanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:277962. [Citirano: 26.04.2024.]

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Podaci o radu
Naslov (engleski)Relationship of Glucose, C-peptide, Leptin, and BDNF in Maternal and Umbilical Vein Blood in Type-1 Diabetes
AutorJosip Đelmiš
AutorSlavko Orešković
AutorVesna Elveđi Gašparović
AutorMirta Starčević
AutorMislav Herman
AutorNada Dessardo
AutorVito Starčević
AutorMarina Ivanišević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA GINEKOLOGIJU I OPSTETRICIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Ginekologija i opstetricija
Sažetak (engleski)
The study aimed to determine the relationship between glucose, C-peptide, brain-derived neurotrophic factor (BDNF), and leptin between mother and fetus and neonatal weight. Methods: In the prospective observational cohort study, we included 66 women with type-1 diabetes mellitus (T1DM). According to the z-score for neonatal weight, patients were divided into healthy-weight neonates (n = 42) and overweight neonates (n = 24). The maternal blood samples were taken during pregnancy and cesarean section when the umbilical vein blood sample was also withdrawn. The maternal vein sera were analyzed for fasting glucose, C-reactive protein (CRP), leptin, BDNF, TSH, FT3, and FT4. The umbilical vein sera were analyzed for glucose, C-peptide, leptin, TSH, thyroid-stimulating protein (FT3), free thyroxine (FT4), and BDNF concentration. The neonatologist measured the skinfold thickness on the third day of neonatal life. Results: A strong correlation was confirmed between maternal and umbilical vein glucose concentration and maternal glucose and C-peptide in umbilical vein blood. A negative correlation was found between the concentration of BDNF in the umbilical vein and glucose in maternal blood. A strong correlation was seen between BMI and maternal blood leptin concentration, neonatal fat body mass, and umbilical vein blood leptin concentration. Higher BMI elevated BDNF, and TSH increase the odds for overweight neonates in the first trimester of pregnancy. Maternal higher leptin concentration in the first trimester decrease the odds of overweight neonates. Conclusions: Maternal glucose concentrations affect the fetus’s glucose, C-peptide, and BDNF concentrations. Leptin levels increase in maternal blood due to increased body mass index, and in the neonate, fat body mass is responsible for increased leptin concentrations.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNutrients
Brojčani podacivol. 15, br. 3, 600
e-ISSN2072-6643
DOIhttps://doi.org/10.3390/nu15030600
URN:NBNurn:nbn:hr:105:277962
Datum objave publikacije2023-01-24
ProjektŠifra: IP-2018-01-1284
Naziv (hrvatski): Prevencija hipoglikemije u trudnica s dijabetesom tipa 1
Kratica: PRE-HYPO
Voditelj: Marina Ivanišević
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
URL dokumentahttps://www.mdpi.com/2072-6643/15/3/600
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-01-16 08:46:57