prikaz prve stranice dokumenta Associations between Endothelial Lipase, High-Density Lipoprotein, and Endothelial Function Differ in Healthy Volunteers and Metabolic Syndrome Patients
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Associations between Endothelial Lipase, High-Density Lipoprotein, and Endothelial Function Differ in Healthy Volunteers and Metabolic Syndrome Patients
International Journal of Molecular Sciences, 24 (2023), 3; 2073. https://doi.org/10.3390/ijms24032073
Klobučar, Iva; Stadler, Julia T.; Klobučar, Lucija; Lechleitner, Margarete; Trbušić, Matias; Pregartner, Gudrun; Berghold, Andrea; Habisch, Hansjörg; Madl, Tobias; Marsche, Gunther; Frank, Saša; Degoricija, Vesna

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Klobučar, I., Stadler, J. T., Klobučar, L., Lechleitner, M., Trbušić, M., Pregartner, G. ... Degoricija, V. (2023). Associations between Endothelial Lipase, High-Density Lipoprotein, and Endothelial Function Differ in Healthy Volunteers and Metabolic Syndrome Patients. International Journal of Molecular Sciences, 24. (3). doi: 10.3390/ijms24032073

Klobučar, Iva, et al. "Associations between Endothelial Lipase, High-Density Lipoprotein, and Endothelial Function Differ in Healthy Volunteers and Metabolic Syndrome Patients." International Journal of Molecular Sciences, vol. 24, br. 3, 2023. https://doi.org/10.3390/ijms24032073

Klobučar, Iva, Julia T. Stadler, Lucija Klobučar, Margarete Lechleitner, Matias Trbušić, Gudrun Pregartner, Andrea Berghold, et al. "Associations between Endothelial Lipase, High-Density Lipoprotein, and Endothelial Function Differ in Healthy Volunteers and Metabolic Syndrome Patients." International Journal of Molecular Sciences 24, br. 3 (2023). https://doi.org/10.3390/ijms24032073

Klobučar, I., et al. (2023) 'Associations between Endothelial Lipase, High-Density Lipoprotein, and Endothelial Function Differ in Healthy Volunteers and Metabolic Syndrome Patients', International Journal of Molecular Sciences, 24(3). doi: 10.3390/ijms24032073

Klobučar I, Stadler JT, Klobučar L, Lechleitner M, Trbušić M, Pregartner G, i sur.. Associations between Endothelial Lipase, High-Density Lipoprotein, and Endothelial Function Differ in Healthy Volunteers and Metabolic Syndrome Patients. International Journal of Molecular Sciences [Internet]. 20.01.2023. [pristupljeno 12.04.2024.];24(3). doi: 10.3390/ijms24032073

I. Klobučar, et al., "Associations between Endothelial Lipase, High-Density Lipoprotein, and Endothelial Function Differ in Healthy Volunteers and Metabolic Syndrome Patients", International Journal of Molecular Sciences, vol. 24, br. 3, Siječanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:631645. [Citirano: 12.04.2024.]

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Naslov (engleski)Associations between Endothelial Lipase, High-Density Lipoprotein, and Endothelial Function Differ in Healthy Volunteers and Metabolic Syndrome Patients
AutorIva Klobučar
AutorJulia T. Stadler
AutorLucija Klobučar
AutorMargarete Lechleitner
AutorMatias Trbušić
AutorGudrun Pregartner
AutorAndrea Berghold
AutorHansjörg Habisch
AutorTobias Madl
AutorGunther Marsche
AutorSaša Frank
AutorVesna Degoricija
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Metabolic syndrome (MS) is characterized by endothelial- and high-density lipoprotein (HDL) dysfunction and increased endothelial lipase (EL) serum levels. We examined the associations between EL serum levels, HDL (serum levels, lipid content, and function), and endothelial function in healthy volunteers (HV) and MS patients. Flow-mediated dilation (FMD), nitroglycerin-mediated dilation (NMD), serum levels of HDL subclasses (measured by nuclear magnetic resonance (NMR) spectroscopy), and EL serum levels differed significantly between HV and MS patients. The serum levels of triglycerides in large HDL particles were significantly positively correlated with FMD and NMD in HV, but not in MS patients. Cholesterol (C) and phospholipid (PL) contents of large HDL particles, calculated as HDL1-C/HDL1-apoA-I and HDL1-PL/HDL1-apoA-I, respectively, were significantly negatively correlated with FMD in HV, but not in MS patients. Cholesterol efflux capacity and arylesterase activity of HDL, as well as EL, were correlated with neither FMD nor NMD. EL was significantly negatively correlated with HDL-PL/HDL-apoA-I in HV, but not in MS patients, and with serum levels of small dense HDL containing apolipoprotein A-II in MS patients, but not in HV. We conclude that MS modulates the association between HDL and endothelial function, as well as between EL and HDL. HDL cholesterol efflux capacity and arylesterase activity, as well as EL serum levels, are not associated with endothelial function in HV or MS patients.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 24, br. 3, 2073
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms24032073
URN:NBNurn:nbn:hr:105:631645
Datum objave publikacije2023-01-20
URL dokumentahttps://www.mdpi.com/1422-0067/24/3/2073
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-01-16 09:02:40