Ekvivalent: Angiotenzin-konvertirajući enzim 2 (ACE2) kao potencijalni dijagnostički i prognostički biomarker za kronične upalne bolesti pluća

završni specijalistički

• Naslov (engleski): Angiotensin-Converting Enzyme 2 (ACE2) as a Potential Diagnostic and Prognostic Biomarker for Chronic Inflammatory Lung Diseases
• Autor: Dejan Marčetić
• Mentor: Miroslav Samaržija (mentor)
• Ustanova koja je dodijelila akademski / stručni stupanj: Sveučilište u Zagrebu; Medicinski fakultet; Zagreb
• Datum i država obrane: 2023-06-15, Hrvatska
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Interna medicina

Sažetak

Abstract: Chronic inflammatory lung diseases are characterized by uncontrolled immune response in the airways as their main pathophysiological manifestation. The lack of specific diagnostic and therapeutic biomarkers for many pulmonary diseases represents a major challenge for pulmonologists. The majority of the currently approved therapeutic approaches are focused on achieving disease remission, although there is no guarantee of complete recovery. It is known that angiotensin-converting enzyme 2 (ACE2), an important counter-regulatory component of the renin–angiotensin–aldosteronesystem (RAAS), is expressed in the airways. It has been shown that ACE2 plays a role in systemic regulation of the cardiovascular and renal systems, lungs and liver by acting on blood pressure, electrolyte balance control mechanisms and inflammation. Its protective role in the lungs has also been presented, but the exact pathophysiological mechanism of action is still elusive. The aim of this study is to review and discuss recent findings about ACE2, including its potential role in the pathophysiology of chronic inflammatory lung diseases:, i.e., chronic obstructive pulmonary disease, asthma, and pulmonary hypertension. Additionally, in the light of the coronavirus 2019 disease (COVID-19), we will discuss the role of ACE2 in the pathophysiology of this disease, mainly represented by different grades of pulmonary problems. We believe that these insights will open up new perspectives for the future use of ACE2 as a potential biomarker for early diagnosis and monitoring of chronic inflammatory lung diseases.

• Ključne riječi: angiotensin-converting enzyme 2 (ACE2); renin-angiotensin-aldosterone system (RAAS); chronic inflammatory lung diseases
• Jezik: engleski
• URN:NBN: urn:nbn:hr:105:798355
• Studijski program: Naziv: Pulmologija; Vrsta studija: sveučilišni; Stupanj studija: poslijediplomski specijalistički; Akademski / stručni naziv: sveučilišni/a magistar/magistra pulmologije (univ. mag. med.)
• Vrsta resursa: Tekst
• Način izrade datoteke: Izvorno digitalna
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2024-01-26 12:26:24