prikaz prve stranice dokumenta Bone morphogenetic protein (BMP)1-3 enhances bone repair
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Bone morphogenetic protein (BMP)1-3 enhances bone repair
Biochemical and Biophysical Research Communications, 408 (2011), 1; 25-31. https://doi.org/10.1016/j.bbrc.2011.03.109
Grgurević, Lovorka; Maček, Boris; Merčep, Mladen; Jelić, Mislav; Smoljanović, Tomislav; Erjavec, Igor; Dumić-Čule, Ivo; Prgomet, Stefan; Đurđević, Dragan; Vnuk, Dražen; Lipar, Marija; Stejskal, Marko; Kufner, Vera; Brkljačić, Jelena; Matičić, Dražen; Vukičević, Slobodan Više autora...

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Grgurević, L., Maček, B., Merčep, M., Jelić, M., Smoljanović, T., Erjavec, I. ... Vukičević, S. (2011). Bone morphogenetic protein (BMP)1-3 enhances bone repair. Biochemical and Biophysical Research Communications, 408. (1), 25-31. doi: 10.1016/j.bbrc.2011.03.109

Grgurević, Lovorka, et al. "Bone morphogenetic protein (BMP)1-3 enhances bone repair." Biochemical and Biophysical Research Communications, vol. 408, br. 1, 2011, str. 25-31. https://doi.org/10.1016/j.bbrc.2011.03.109

Grgurević, Lovorka, Boris Maček, Mladen Merčep, Mislav Jelić, Tomislav Smoljanović, Igor Erjavec, Ivo Dumić Čule, et al. "Bone morphogenetic protein (BMP)1-3 enhances bone repair." Biochemical and Biophysical Research Communications 408, br. 1 (2011): 25-31. https://doi.org/10.1016/j.bbrc.2011.03.109

Grgurević, L., et al. (2011) 'Bone morphogenetic protein (BMP)1-3 enhances bone repair', Biochemical and Biophysical Research Communications, 408(1), str. 25-31. doi: 10.1016/j.bbrc.2011.03.109

Grgurević L, Maček B, Merčep M, Jelić M, Smoljanović T, Erjavec I, i sur.. Bone morphogenetic protein (BMP)1-3 enhances bone repair. Biochemical and Biophysical Research Communications [Internet]. 29.04.2011. [pristupljeno 29.11.2024.];408(1):25-31. doi: 10.1016/j.bbrc.2011.03.109

L. Grgurević, et al., "Bone morphogenetic protein (BMP)1-3 enhances bone repair", Biochemical and Biophysical Research Communications, vol. 408, br. 1, str. 25-31, Travanj 2011. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:755290. [Citirano: 29.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:755290
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Podaci o radu
Naslov (engleski)Bone morphogenetic protein (BMP)1-3 enhances bone repair
AutorLovorka Grgurević
AutorBoris Maček
AutorMladen Merčep
AutorMislav Jelić
AutorTomislav Smoljanović
AutorIgor Erjavec
AutorIvo Dumić-Čule
AutorStefan Prgomet
AutorDragan Đurđević
AutorDražen Vnuk
AutorMarija Lipar
AutorMarko Stejskal
AutorVera Kufner
AutorJelena Brkljačić
AutorDražen Matičić
AutorSlobodan Vukičević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Members of the astacin family of metalloproteinases such as human bone morphogenetic protein 1 (BMP-1) regulate morphogenesis by processing precursors to mature functional extracellular matrix (ECM) proteins and several growth factors including TGFβ, BMP2, BMP4 and GFD8. We have recently discovered that BMP1-3 isoform of the Bmp-1 gene circulates in the human plasma and is significantly increased in patients with acute bone fracture. We hypothesized that circulating BMP1-3 might have an important role in bone repair and serve as a novel bone biomarker. When administered systemically to rats with a long bone fracture and locally to rabbits with a critical size defect of the ulna, recombinant human BMP1-3 enhanced bone healing. In contrast, neutralization of the endogenous BMP1-3 by a specific polyclonal antibody delayed the bone union. Invitro BMP1-3 increased the expression of collagen type I and osteocalcin in MC3T3-E(1) osteoblast like cells, and enhanced the formation of mineralized bone nodules from bone marrow mesenchymal stem cells. We suggest that BMP1-3 is a novel systemic regulator of bone repair.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaBiochemical and Biophysical Research Communications
Brojčani podacivol. 408, br. 1, str. 25-31
p-ISSN0006-291X
DOIhttps://doi.org/10.1016/j.bbrc.2011.03.109
URN:NBNurn:nbn:hr:105:755290
Datum objave publikacije2011-04-29
URL dokumentahttps://doi.org/10.1016/j.bbrc.2011.03.109
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-27 19:02:43