prikaz prve stranice dokumenta A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning
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A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning
Acta Biochimica Polonica, 58 (2011), 2; 193-198. urn:nbn:hr:105:126735
Lovrić, Jasna; Berend, Suzana; Lucić Vrdoljak, Ana; Radić, Božica; Katalinić, Maja; Kovarik, Zrinka; Želježić, Davor; Kopjar, Nevenka; Rast, Slavko; Mesić, Milan

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Lovrić, J., Berend, S., Lucić Vrdoljak, A., Radić, B., Katalinić, M., Kovarik, Z. ... Mesić, M. (2011). A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning. Acta Biochimica Polonica, 58. (2), 193-198. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:105:126735

Lovrić, Jasna, et al. "A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning." Acta Biochimica Polonica, vol. 58, br. 2, 2011, str. 193-198. https://urn.nsk.hr/urn:nbn:hr:105:126735

Lovrić, Jasna, Suzana Berend, Ana Lucić Vrdoljak, Božica Radić, Maja Katalinić, Zrinka Kovarik, Davor Želježić, Nevenka Kopjar, Slavko Rast i Milan Mesić. "A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning." Acta Biochimica Polonica 58, br. 2 (2011): 193-198. https://urn.nsk.hr/urn:nbn:hr:105:126735

Lovrić, J., et al. (2011) 'A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning', Acta Biochimica Polonica, 58(2), str. 193-198. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:105:126735 (Datum pristupa: 06.05.2024.)

Lovrić J, Berend S, Lucić Vrdoljak A, Radić B, Katalinić M, Kovarik Z, i sur.. A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning. Acta Biochimica Polonica [Internet]. 2011. [pristupljeno 06.05.2024.];58(2):193-198. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:126735

J. Lovrić, et al., "A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning", Acta Biochimica Polonica, vol. 58, br. 2, str. 193-198, 2011. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:126735. [Citirano: 06.05.2024.]

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Naslov (engleski)A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning
AutorJasna Lovrić
AutorSuzana Berend
AutorAna Lucić Vrdoljak
AutorBožica Radić
AutorMaja Katalinić
AutorZrinka Kovarik
AutorDavor Želježić
AutorNevenka Kopjar
AutorSlavko Rast
AutorMilan Mesić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
A conjugate of pyridine-4-aldoxime and atropine (ATR-4-OX) was synthesized and its antidotal efficiency was tested in vitro on tabun- or paraoxon-inhibited acetylcholinesterase (AChE) of human erythrocytes as well as in vivo using soman-, tabun- or paraoxon-poisoned mice. Its genotoxic profile was assessed on human lymphocytes in vitro and was found acceptable for further research. ATR-4-OX showed very weak antidotal activity, inadequate for soman or tabun poisoning. Conversely, it was effective against paraoxon poisoning both in vitro and in vivo. All animals treated with 5 % or 25 % LD(50) doses of the new oxime survived after administration of 10.0 or 16.0 LD(50) doses of paraoxon, respectively. Based on the persistence of toxicity symptoms in mice, the atropine moiety had questionable effects in attenuating such symptoms. It appears that ATR-4-OX has a therapeutic effect related to the reactivation of phosphylated AChE, but not to receptor antagonization.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaActa Biochimica Polonica
Brojčani podacivol. 58, br. 2, str. 193-198
p-ISSN0001-527X
URN:NBNurn:nbn:hr:105:126735
Datum objave publikacije2011
URL dokumentahttp://www.actabp.pl/pdf/2_2011/193.pdf
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-27 19:03:43