prikaz prve stranice dokumenta Gene polymorphisms of the renin-angiotensin system and early development of hypertension
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Gene polymorphisms of the renin-angiotensin system and early development of hypertension
American Journal of Hypertension, 19 (2006), 8; 837-842. https://doi.org/10.1016/j.amjhyper.2006.01.004
Barbalić, Maja; Škarić-Jurić, Tatjana; Cambien, François; Barbaux, Sandrine; Poirier, Odette; Turek, Stjepan; Vrhovski-Hebrang, Danijela; Čubrilo-Turek, Mirjana; Rudan, Igor; Rudan, Pavao; Smolej-Narančić, Nina

Citirajte ovaj rad

Barbalić, M., Škarić Jurić, T., Cambien, F., Barbaux, S., Poirier, O., Turek, S. ... Smolej Narančić, N. (2006). Gene polymorphisms of the renin-angiotensin system and early development of hypertension. American Journal of Hypertension, 19. (8), 837-842. doi: 10.1016/j.amjhyper.2006.01.004

Barbalić, Maja, et al. "Gene polymorphisms of the renin-angiotensin system and early development of hypertension." American Journal of Hypertension, vol. 19, br. 8, 2006, str. 837-842. https://doi.org/10.1016/j.amjhyper.2006.01.004

Barbalić, Maja, Tatjana Škarić Jurić, François Cambien, Sandrine Barbaux, Odette Poirier, Stjepan Turek, Danijela Vrhovski Hebrang, et al. "Gene polymorphisms of the renin-angiotensin system and early development of hypertension." American Journal of Hypertension 19, br. 8 (2006): 837-842. https://doi.org/10.1016/j.amjhyper.2006.01.004

Barbalić, M., et al. (2006) 'Gene polymorphisms of the renin-angiotensin system and early development of hypertension', American Journal of Hypertension, 19(8), str. 837-842. doi: 10.1016/j.amjhyper.2006.01.004

Barbalić M, Škarić Jurić T, Cambien F, Barbaux S, Poirier O, Turek S, i sur.. Gene polymorphisms of the renin-angiotensin system and early development of hypertension. American Journal of Hypertension [Internet]. 08.2006. [pristupljeno 04.05.2024.];19(8):837-842. doi: 10.1016/j.amjhyper.2006.01.004

M. Barbalić, et al., "Gene polymorphisms of the renin-angiotensin system and early development of hypertension", American Journal of Hypertension, vol. 19, br. 8, str. 837-842, Kolovoz 2006. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:196637. [Citirano: 04.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:196637
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Podaci o radu
Naslov (engleski)Gene polymorphisms of the renin-angiotensin system and early development of hypertension
AutorMaja Barbalić
AutorTatjana Škarić-Jurić
AutorFrançois Cambien
AutorSandrine Barbaux
AutorOdette Poirier
AutorStjepan Turek
AutorDanijela Vrhovski-Hebrang
AutorMirjana Čubrilo-Turek
AutorIgor Rudan
AutorPavao Rudan
AutorNina Smolej-Narančić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND: A case-control association study was conducted to investigate a possible involvement of polymorphisms of three renin-angiotensin system genes: ACE (I/D and T-3892C), AGT (M235T and T174M), and AT1R (A1166C) in the early development of hypertension. ----- METHODS: One hundred nineteen hypertensive and 125 normotensive participants aged 18 to 40 years were selected from a broader sample representative of the general population of Croatia. The selection criteria for hypertensive cases were systolic blood pressure (BP) higher than 140 mm Hg or diastolic BP higher than 90 mm Hg and a history of hypertension according to patient interview. ----- RESULTS: Among the polymorphisms investigated, only those located on the ACE gene were associated with hypertension. For ACE I/D, the odds ratio for hypertension of DD versus II homozygote individuals was 2.50 (95% confidence interval [CI] 1.19-5.25) and for ACE T-3892C, the odds ratio of CC versus TT individuals was 2.32 (95% CI 1.05-5.10). Both polymorphisms of the ACE gene were in tight linkage disequilibrium. Of the investigated risk factors for hypertension, only body mass index (BMI) showed an influence on the early development of hypertension, acting independently of the ACE polymorphism. Their additive effect gives rise to 86% of hypertensives in subjects having both the DD genotype and BMI >or=30 kg/m(2). ----- CONCLUSIONS: The present study provides evidence of the association of the ACE gene polymorphisms and premature hypertension. In addition, BMI proved to be another important predictor of the disorder acting independently of the ACE gene.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaAmerican Journal of Hypertension
Brojčani podacivol. 19, br. 8, str. 837-842
p-ISSN0895-7061
DOIhttps://doi.org/10.1016/j.amjhyper.2006.01.004
URN:NBNurn:nbn:hr:105:196637
Datum objave publikacije2006-08
URL dokumentahttps://doi.org/10.1016/j.amjhyper.2006.01.004
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-27 19:08:23