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Pilot study of the association between the HLA region and testicular carcinoma among Croatian patients
Urologia Internationalis, 87 (2011), 3; 288-292. https://doi.org/10.1159/000329770
Gotovac, Kristina; Grubić, Zorana; Kaštelan, Željko; Štingl, Katarina; Kuliš, Tomislav; Krhen, Ivan; Hudolin, Tvrtko; Kaštelan, Maja; Žunec, Renata

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Gotovac, K., Grubić, Z., Kaštelan, Ž., Štingl, K., Kuliš, T., Krhen, I. ... Žunec, R. (2011). Pilot study of the association between the HLA region and testicular carcinoma among Croatian patients. Urologia Internationalis, 87. (3), 288-292. doi: 10.1159/000329770

Gotovac, Kristina, et al. "Pilot study of the association between the HLA region and testicular carcinoma among Croatian patients." Urologia Internationalis, vol. 87, br. 3, 2011, str. 288-292. https://doi.org/10.1159/000329770

Gotovac, Kristina, Zorana Grubić, Željko Kaštelan, Katarina Štingl, Tomislav Kuliš, Ivan Krhen, Tvrtko Hudolin, Maja Kaštelan i Renata Žunec. "Pilot study of the association between the HLA region and testicular carcinoma among Croatian patients." Urologia Internationalis 87, br. 3 (2011): 288-292. https://doi.org/10.1159/000329770

Gotovac, K., et al. (2011) 'Pilot study of the association between the HLA region and testicular carcinoma among Croatian patients', Urologia Internationalis, 87(3), str. 288-292. doi: 10.1159/000329770

Gotovac K, Grubić Z, Kaštelan Ž, Štingl K, Kuliš T, Krhen I, i sur.. Pilot study of the association between the HLA region and testicular carcinoma among Croatian patients. Urologia Internationalis [Internet]. 2011. [pristupljeno 17.10.2024.];87(3):288-292. doi: 10.1159/000329770

K. Gotovac, et al., "Pilot study of the association between the HLA region and testicular carcinoma among Croatian patients", Urologia Internationalis, vol. 87, br. 3, str. 288-292, 2011. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:712654. [Citirano: 17.10.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:712654
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Podaci o radu
Naslov (engleski)Pilot study of the association between the HLA region and testicular carcinoma among Croatian patients
AutorKristina Gotovac
AutorZorana Grubić
AutorŽeljko Kaštelan
AutorKatarina Štingl
AutorTomislav Kuliš
AutorIvan Krhen
AutorTvrtko Hudolin
AutorMaja Kaštelan
AutorRenata Žunec
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
OBJECTIVES: To analyze the distribution of HLA alleles and HLA microsatellite alleles in Croatian patients with testicular carcinoma, compare it with that of healthy controls and investigate whether the polymorphism within the HLA region could be associated with the development of testicular cancer. ----- METHODS: Genomic DNA was isolated from the peripheral blood of 24 patients with testicular germ cell tumors (TGCT). Patients and controls were typed for HLA class I and class II polymorphism by the PCR-SSO method. Nine HLA microsatellites were analyzed by PCR and electrophoresis in an automated sequencer. ----- RESULTS: No significant deviation in the distribution of frequencies at HLA class I alleles was observed between patients and controls. Among HLA class II alleles, a statistically significant increase in the frequency of the HLA-DPB1*1701 allele was found among patients. The frequency of the HLA-DRB1*07-DQA1*0201-DQB1*0202 haplotype was increased in patients in comparison to the controls. Analysis of HLA microsatellites showed an increased frequency of D6S291-3 allele (p(corr) = 0.0455, OR = 3.05) among patients. ----- CONCLUSIONS: The observed association of the disease and the DPB1*1701 allele as well as with the D6S291-3 allele suggests that this part of the HLA region might be involved in the pathogenesis of TGCT. Our data provide a basis for further studies about the correlation between the HLA region and testicular cancer.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaUrologia Internationalis
Brojčani podacivol. 87, br. 3, str. 288-292
p-ISSN0042-1138
DOIhttps://doi.org/10.1159/000329770
URN:NBNurn:nbn:hr:105:712654
Datum objave publikacije2011
URL dokumentahttps://doi.org/10.1159/000329770
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-27 19:09:25