prikaz prve stranice dokumenta Pharmaceutical principles of acid inhibitors: unmet needs
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Pharmaceutical principles of acid inhibitors: unmet needs
Digestive Diseases, 29 (2011), 5; 469-475. https://doi.org/10.1159/000331515
Krznarić, Željko; Ljubas Kelečić, Dina; Rustemović, Nadan; Vranešić Bender, Darija; Ostojić, Rajko; Markoš, Pave; Scarpignato, Carmelo

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Krznarić, Ž., Ljubas Kelečić, D., Rustemović, N., Vranešić Bender, D., Ostojić, R., Markoš, P. i Scarpignato, C. (2011). Pharmaceutical principles of acid inhibitors: unmet needs. Digestive Diseases, 29. (5), 469-475. doi: 10.1159/000331515

Krznarić, Željko, et al. "Pharmaceutical principles of acid inhibitors: unmet needs." Digestive Diseases, vol. 29, br. 5, 2011, str. 469-475. https://doi.org/10.1159/000331515

Krznarić, Željko, Dina Ljubas Kelečić, Nadan Rustemović, Darija Vranešić Bender, Rajko Ostojić, Pave Markoš i Carmelo Scarpignato. "Pharmaceutical principles of acid inhibitors: unmet needs." Digestive Diseases 29, br. 5 (2011): 469-475. https://doi.org/10.1159/000331515

Krznarić, Ž., et al. (2011) 'Pharmaceutical principles of acid inhibitors: unmet needs', Digestive Diseases, 29(5), str. 469-475. doi: 10.1159/000331515

Krznarić Ž, Ljubas Kelečić D, Rustemović N, Vranešić Bender D, Ostojić R, Markoš P, i sur.. Pharmaceutical principles of acid inhibitors: unmet needs. Digestive Diseases [Internet]. 2011. [pristupljeno 15.04.2024.];29(5):469-475. doi: 10.1159/000331515

Ž. Krznarić, et al., "Pharmaceutical principles of acid inhibitors: unmet needs", Digestive Diseases, vol. 29, br. 5, str. 469-475, 2011. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:915594. [Citirano: 15.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:915594
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Podaci o radu
Naslov (engleski)Pharmaceutical principles of acid inhibitors: unmet needs
AutorŽeljko Krznarić
AutorDina Ljubas Kelečić
AutorNadan Rustemović
AutorDarija Vranešić Bender
AutorRajko Ostojić
AutorPave Markoš
AutorCarmelo Scarpignato
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Despite the well-established benefits of currently approved delayed-release proton pump inhibitors (PPIs) in the treatment of acid-related diseases, the unmet needs are still present and although often frustrating, they challenge clinicians. The unmet needs relate to the lack of complete control of acid secretion with oral PPI administration in the management of patients with gastroesophageal symptoms. These substantial groups of patients, who do not respond completely to standard doses of PPIs, are nonresponders, and their lack of response should be considered as PPI failure. Several mechanisms could explain PPI failure: differences in pharmacokinetics, PPI formulation, dosing time and diet, noncompliance, transient lower esophageal sphincter relaxations, esophageal hypersensitivity, and nocturnal acid breakthrough. To increase the quality of life of these patients and avoid multiple medical consultations and unnecessary investigations, we have to go one step forward and use combined therapy or look towards new treatments beyond acid suppression.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeStručni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaDigestive Diseases
Brojčani podacivol. 29, br. 5, str. 469-475
p-ISSN0257-2753
DOIhttps://doi.org/10.1159/000331515
URN:NBNurn:nbn:hr:105:915594
Datum objave publikacije2011
URL dokumentahttps://doi.org/10.1159/000331515
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-27 19:12:41