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Do we need broad immunological work-up in all patients with CIS?
Journal of the Neurological Sciences, 315 (2012), 1-2; 86-88. https://doi.org/10.1016/j.jns.2011.11.023
Adamec, Ivan; Bošković, Mateja; Škvorc, Ana; Posavec, Vanja; Radmilović, Marin; Gabelić, Tereza; Habek, Mario

Citirajte ovaj rad

Adamec, I., Bošković, M., Škvorc, A., Posavec, V., Radmilović, M., Gabelić, T. i Habek, M. (2012). Do we need broad immunological work-up in all patients with CIS?. Journal of the Neurological Sciences, 315. (1-2), 86-88. doi: 10.1016/j.jns.2011.11.023

Adamec, Ivan, et al. "Do we need broad immunological work-up in all patients with CIS?." Journal of the Neurological Sciences, vol. 315, br. 1-2, 2012, str. 86-88. https://doi.org/10.1016/j.jns.2011.11.023

Adamec, Ivan, Mateja Bošković, Ana Škvorc, Vanja Posavec, Marin Radmilović, Tereza Gabelić i Mario Habek. "Do we need broad immunological work-up in all patients with CIS?." Journal of the Neurological Sciences 315, br. 1-2 (2012): 86-88. https://doi.org/10.1016/j.jns.2011.11.023

Adamec, I., et al. (2012) 'Do we need broad immunological work-up in all patients with CIS?', Journal of the Neurological Sciences, 315(1-2), str. 86-88. doi: 10.1016/j.jns.2011.11.023

Adamec I, Bošković M, Škvorc A, Posavec V, Radmilović M, Gabelić T, i sur.. Do we need broad immunological work-up in all patients with CIS?. Journal of the Neurological Sciences [Internet]. 15.04.2012. [pristupljeno 13.04.2024.];315(1-2):86-88. doi: 10.1016/j.jns.2011.11.023

I. Adamec, et al., "Do we need broad immunological work-up in all patients with CIS?", Journal of the Neurological Sciences, vol. 315, br. 1-2, str. 86-88, Travanj 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:237810. [Citirano: 13.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:237810
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Podaci o radu
Naslov (engleski)Do we need broad immunological work-up in all patients with CIS?
AutorIvan Adamec
AutorMateja Bošković
AutorAna Škvorc
AutorVanja Posavec
AutorMarin Radmilović
AutorTereza Gabelić
AutorMario Habek
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND: The aim of this study was to determine the prevalence of altered immunological tests and their clinical significance in patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS). ----- PATIENTS AND METHODS: The information was gathered from medical records of patients hospitalized in the Referral Center for Demyelinating Diseases in the 2008-2010 period. All patients had ANA, ENA profile, ANCA, aCl IgG and IgM, C3, C4, CH50, anti-TPO, AST and RF antibodies tested. ----- RESULTS: From 726 patients with CIS that were reviewed, the complete battery of immunological tests was performed in 418 of them (57.6%), representing our cohort. Altered tests were found in 235 patients (56.2%); 73 (17.4%) had positive antinuclear antibodies, 14 (3.3%) had positive ENA, 47 (11.2%) had positive aCl IgG, 83 (19.8%) had positive aCl IgM, and 13 (3.1%) had anti TPO antibodies. We found no correlation between ANA, aCl IgG or IgM positivity (ANA vs aCL IgG p=0.554; ANA vs aCL IgM p=0.19; aCL IgG vs aCL IgM, p=0.155). None of the patients had any clinical manifestations other than MS symptoms. ----- CONCLUSION: These results indicate that significant number of patients with CIS have altered immunological tests but nevertheless none of them had clinical expression of any other autoimmune disease making them clinically insignificant. In conclusion there is no need to perform extensive immunological work-up in all patients with CIS. Contrary, our results argue for more focused testing rather than a battery of screening tests.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaJournal of the Neurological Sciences
Brojčani podacivol. 315, br. 1-2, str. 86-88
p-ISSN0022-510X
DOIhttps://doi.org/10.1016/j.jns.2011.11.023
URN:NBNurn:nbn:hr:105:237810
Datum objave publikacije2012-04-15
URL dokumentahttps://doi.org/10.1016/j.jns.2011.11.023
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-27 19:27:33