Relationship of bone mineral density with disease activity and functional ability in patients with ankylosing spondylitis: a cross-sectional study

Znanstveni rad - Izvorni znanstveni rad

• Autor: Simeon Grazio
• Autor: Zvonko Kusić
• Autor: Selma Cvijetić
• Autor: Frane Grubišić
• Autor: Antonija Balenović
• Autor: Tomislav Nemčić
• Autor: Valentina Matijević-Mikelić
• Autor: Marija Punda
• Autor: Joachim Sieper
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti

Sažetak (engleski)

In ankylosing spondylitis, inflammatory activity probably plays a key role in the pathophysiology of bone loss. The aim of the study was to investigate the relationship of bone mineral density (BMD) at the lumbar spine and hip region with some measures of disease activity and functional ability in patients with ankylosing spondylitis. In 80 patients with established ankylosing spondylitis, disease activity and functional ability were determined by C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI). Spinal pain and patient global health were assessed using horizontal visual analog scale. BMD was measured by dual-energy X-ray absorptiometry. There was a significant negative correlation of bone density T scores with acute-phase reactants (i.e., patients with lower T scores had higher level of CRP and ESR). That relationship was reflected more reliably at proximal femur sites than at the lumbar spine. There were also significant differences in ESR, BASDAI, BASFI, spinal pain and global health between three groups of patients according to WHO classification of osteoporosis (normal, osteopenic and osteoporotic). Significantly, more patients with osteopenia at the lumbar spine had lower BASDAI index than those with normal BMD (P = 0.030). Our results indicate an association of low BMD with high disease activity in patients with AS. Femoral BMD seems to be more associated with disease activity and functional ability than lumbar spine BMD.

• Ključne riječi (engleski): Adult; Blood Sedimentation; Bone Density / physiology; Bone Diseases, Metabolic / epidemiology; Bone Diseases, Metabolic / etiology; C-Reactive Protein / metabolism; Cross-Sectional Studies; Disability Evaluation; Female; Femur Neck / physiopathology; Humans; Incidence; Lumbar Vertebrae / physiopathology; Male; Middle Aged; Osteoporosis / epidemiology; Osteoporosis / etiology; Severity of Illness Index; Spondylitis, Ankylosing / blood; Spondylitis, Ankylosing / complications; Spondylitis, Ankylosing / physiopathology
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Završna verzija rukopisa prihvaćena za objavljivanje (postprint)
• Naslov časopisa: Rheumatology International
• Brojčani podaci: vol. 32, br. 9, str. 2801-2808
• p-ISSN: 0172-8172
• DOI: https://doi.org/10.1007/s00296-011-2066-9
• URN:NBN: urn:nbn:hr:105:714535
• Datum objave publikacije: 2012-09
• URL dokumenta: https://doi.org/10.1007/s00296-011-2066-9
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2024-03-27 19:31:24