prikaz prve stranice dokumenta Computed microtomography visualization and quantification of mouse ischemic brain lesion by nonionic radio contrast agents
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Computed microtomography visualization and quantification of mouse ischemic brain lesion by nonionic radio contrast agents
Croatian Medical Journal, 54 (2013), 1; 3-11. https://doi.org/10.3325/cmj.2013.54.3
Dobrivojević, Marina; Bohaček, Ivan; Erjavec, Igor; Gorup, Dunja; Gajović, Srećko

Citirajte ovaj rad

Dobrivojević, M., Bohaček, I., Erjavec, I., Gorup, D. i Gajović, S. (2013). Computed microtomography visualization and quantification of mouse ischemic brain lesion by nonionic radio contrast agents. Croatian Medical Journal, 54. (1), 3-11. doi: 10.3325/cmj.2013.54.3

Dobrivojević, Marina, et al. "Computed microtomography visualization and quantification of mouse ischemic brain lesion by nonionic radio contrast agents." Croatian Medical Journal, vol. 54, br. 1, 2013, str. 3-11. https://doi.org/10.3325/cmj.2013.54.3

Dobrivojević, Marina, Ivan Bohaček, Igor Erjavec, Dunja Gorup i Srećko Gajović. "Computed microtomography visualization and quantification of mouse ischemic brain lesion by nonionic radio contrast agents." Croatian Medical Journal 54, br. 1 (2013): 3-11. https://doi.org/10.3325/cmj.2013.54.3

Dobrivojević, M., et al. (2013) 'Computed microtomography visualization and quantification of mouse ischemic brain lesion by nonionic radio contrast agents', Croatian Medical Journal, 54(1), str. 3-11. doi: 10.3325/cmj.2013.54.3

Dobrivojević M, Bohaček I, Erjavec I, Gorup D, Gajović S. Computed microtomography visualization and quantification of mouse ischemic brain lesion by nonionic radio contrast agents. Croatian Medical Journal [Internet]. 02.2013. [pristupljeno 09.11.2024.];54(1):3-11. doi: 10.3325/cmj.2013.54.3

M. Dobrivojević, I. Bohaček, I. Erjavec, D. Gorup i S. Gajović, "Computed microtomography visualization and quantification of mouse ischemic brain lesion by nonionic radio contrast agents", Croatian Medical Journal, vol. 54, br. 1, str. 3-11, Veljača 2013. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:199163. [Citirano: 09.11.2024.]

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Podaci o radu
Naslov (engleski)Computed microtomography visualization and quantification of mouse ischemic brain lesion by nonionic radio contrast agents
AutorMarina Dobrivojević
AutorIvan Bohaček
AutorIgor Erjavec
AutorDunja Gorup
AutorSrećko Gajović
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
AIM: To explore the possibility of brain imaging by microcomputed tomography (microCT) using x-ray contrasting methods to visualize mouse brain ischemic lesions after middle cerebral artery occlusion (MCAO). ----- METHODS: Isolated brains were immersed in ionic or nonionic radio contrast agent (RCA) for 5 days and subsequently scanned using microCT scanner. To verify whether ex-vivo microCT brain images can be used to characterize ischemic lesions, they were compared to Nissl stained serial histological sections of the same brains. To verify if brains immersed in RCA may be used afterwards for other methods, subsequent immunofluorescent labeling with anti-NeuN was performed. ----- RESULTS: Nonionic RCA showed better gray to white matter contrast in the brain, and therefore was selected for further studies. MicroCT measurement of ischemic lesion size and cerebral edema significantly correlated with the values determined by Nissl staining (ischemic lesion size: P=0.0005; cerebral edema: P=0.0002). Brain immersion in nonionic RCA did not affect subsequent immunofluorescent analysis and NeuN immunoreactivity. ----- CONCLUSION: MicroCT method was proven to be suitable for delineation of the ischemic lesion from the non-infarcted tissue, and quantification of lesion volume and cerebral edema.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 54, br. 1, str. 3-11
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2013.54.3
URN:NBNurn:nbn:hr:105:199163
Datum objave publikacije2013-02
URL dokumentahttps://doi.org/10.3325/cmj.2013.54.3
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-27 19:51:48