prikaz prve stranice dokumenta MDR1 polymorphisms are associated with inflammatory bowel disease in a cohort of Croatian IBD patients
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MDR1 polymorphisms are associated with inflammatory bowel disease in a cohort of Croatian IBD patients
BMC Gastroenterology, 13 (2013), 1; 57. https://doi.org/10.1186/1471-230X-13-57
Brinar, Marko; Čuković-Čavka, Silvija; Božina, Nada; Grubelić Ravić, Katja; Markoš, Pave; Ladić, Agata; Cota, Marijana; Krznarić, Željko; Vucelić, Boris

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Brinar, M., Čuković Čavka, S., Božina, N., Grubelić Ravić, K., Markoš, P., Ladić, A. ... Vucelić, B. (2013). MDR1 polymorphisms are associated with inflammatory bowel disease in a cohort of Croatian IBD patients. BMC Gastroenterology, 13. (1), 57. doi: 10.1186/1471-230X-13-57

Brinar, Marko, et al. "MDR1 polymorphisms are associated with inflammatory bowel disease in a cohort of Croatian IBD patients." BMC Gastroenterology, vol. 13, br. 1, 2013, str. 57. https://doi.org/10.1186/1471-230X-13-57

Brinar, Marko, Silvija Čuković Čavka, Nada Božina, Katja Grubelić Ravić, Pave Markoš, Agata Ladić, Marijana Cota, Željko Krznarić i Boris Vucelić. "MDR1 polymorphisms are associated with inflammatory bowel disease in a cohort of Croatian IBD patients." BMC Gastroenterology 13, br. 1 (2013): 57. https://doi.org/10.1186/1471-230X-13-57

Brinar, M., et al. (2013) 'MDR1 polymorphisms are associated with inflammatory bowel disease in a cohort of Croatian IBD patients', BMC Gastroenterology, 13(1), str. 57. doi: 10.1186/1471-230X-13-57

Brinar M, Čuković Čavka S, Božina N, Grubelić Ravić K, Markoš P, Ladić A, i sur.. MDR1 polymorphisms are associated with inflammatory bowel disease in a cohort of Croatian IBD patients. BMC Gastroenterology [Internet]. 27.03.2013. [pristupljeno 14.04.2024.];13(1):57. doi: 10.1186/1471-230X-13-57

M. Brinar, et al., "MDR1 polymorphisms are associated with inflammatory bowel disease in a cohort of Croatian IBD patients", BMC Gastroenterology, vol. 13, br. 1, str. 57, Ožujak 2013. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:357896. [Citirano: 14.04.2024.]

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Podaci o radu
Naslov (engleski)MDR1 polymorphisms are associated with inflammatory bowel disease in a cohort of Croatian IBD patients
AutorMarko Brinar
AutorSilvija Čuković-Čavka
AutorNada Božina
AutorKatja Grubelić Ravić
AutorPave Markoš
AutorAgata Ladić
AutorMarijana Cota
AutorŽeljko Krznarić
AutorBoris Vucelić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND: Inflammatory bowel diseases (IBD) are chronic diseases of unknown etiology and pathogenesis in which genetic factors contribute to development of disease. MDR1/ABCB1 is an interesting candidate gene for IBD. The role of two single nucleotide polymorphisms, C3435T and G2677T remains unclear due to contradictory results of current studies. Thus, the aims of this research were to investigate the association of MDR1 polymorphisms, C3435T and G2677T, and IBD. ----- METHODS: A total of 310 IBD patients, 199 Crohn's disease (CD) patients and 109 ulcerative colitis (UC) patients, and 120 healthy controls were included in the study. All subjects were genotyped for G2677T/A and C3435T polymorphism using RT-PCR. In IBD patients, review of medical records was performed and patients were phenotyped according to the Montreal classification. ----- RESULTS: Significantly higher frequency of 2677T allele (p=0.05; OR 1.46, 95% CI (1.0-2.14)) and of the 3435TT genotype was observed among UC patients compared to controls (p=0.02; OR 2.12; 95% CI (1.11-4.03). Heterozygous carriers for C3435T were significantly less likely to have CD (p=0.02; OR 0.58, 95% CI (0.36-0.91)). Haplotype analysis revealed that carriers of 3435T/2677T haplotype had a significantly higher risk of having UC (p=0.02; OR 1.55; 95% CI (1.06-2.28)). ----- CONCLUSION: MDR1 polymorphisms are associated with both CD and UC with a stronger association with UC.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBMC Gastroenterology
Brojčani podacivol. 13, br. 1, str. 57
p-ISSN1471-230X
DOIhttps://doi.org/10.1186/1471-230X-13-57
URN:NBNurn:nbn:hr:105:357896
Datum objave publikacije2013-03-27
URL dokumentahttps://doi.org/10.1186/1471-230X-13-57
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-27 19:59:25